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Sample Business Contracts

Placement Agent's Warrant - Biopure Corp. and Shoreline Pacific LLC

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          THIS WARRANT AND THE SHARES OF COMMON STOCK THAT ARE ISSUABLE UPON
          EXERCISE OF THE WARRANT MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
          OTHERWISE TRANSFERRED UNLESS SUCH TRANSFER IS REGISTERED OR QUALIFIED
          UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND APPLICABLE STATE
          SECURITIES LAWS OR UNLESS THE CORPORATION RECEIVES AN OPINION OF
          COUNSEL OR OTHER EVIDENCE REASONABLY SATISFACTORY TO IT TO THE EFFECT
          THAT SUCH REGISTRATION AND QUALIFICATION ARE NOT REQUIRED

            Warrant to Purchase 65,000 Shares of Class A Common Stock
             (including associated preferred stock purchase rights)


                            PLACEMENT AGENT'S WARRANT


                              Dated: April 23, 2002

     This certifies that SHORELINE PACIFIC, LLC (herein sometimes called the
"Placement Agent") or its permitted transferee (the Placement Agent or any such
transferee is sometimes herein called the "Holder") is entitled to purchase from
BIOPURE CORPORATION, a Delaware corporation (the "Company"), at the price and
during the period as hereinafter specified, up to 65,000 shares (equal to three
percent of the number of Shares (as defined below) sold to the Investors
pursuant to the purchase agreements in the form included as Exhibit A to the
Placement Agency Agreement (defined below), but not including purchasers signing
substantially the same form and described in Section 4(i) of the Placement
Agency Agreement), including associated preferred stock purchase rights under
that certain Rights Agreement (the "Rights Agreement") dated as of as of
September 24, 1999 between the Company and American Stock Transfer & Trust
Company, as Rights Agent (such shares collectively with such associated rights,
the "Shares") of Class A common stock, $0.01 par value per share, of the Company
(the "Common Stock") at a purchase price of $7.53 per share (equal to the
closing price of a Share, as reported on The Nasdaq Stock Market on the Closing
Date (as defined below) subject to adjustment as described below (as so adjusted
from time to time, the "Exercise Price"), at any time during the three-(3) year
period commencing one (1) year from the Closing Date (as defined in the
Placement Agency Agreement).

     This Placement Agent's Warrant (the "Placement Agent's Warrant") is issued
pursuant to a Placement Agency Agreement between the Company and Shoreline
Pacific, LLC, as Placement Agent, in connection with a public offering, through
the reasonable best efforts of the Placement Agent, of up 2,666,666 Shares as
therein described (the "Placement Agency Agreement"). Except as specifically
otherwise provided herein, the Shares issued pursuant to the Placement Agent's
Warrant shall bear the same terms and conditions as described under the caption
"Description of Capital Stock" in the


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Prospectus Supplement defined in the Placement Agency Agreement except that the
Holder shall have registration rights under the Securities Act of 1933, as
amended (the "Act"), for the Shares issuable pursuant the Placement Agent's
Warrant as more fully described in Section 6 herein.

     1. The rights represented by the Placement Agent's Warrant shall be
exercisable at the Exercise Price, and during the periods as follows:

          (a) During the period from the Closing Date to and through April 22,
2003 (the "First Anniversary Date"), inclusive, the Holder shall have no right
to purchase any Shares hereunder.

          (b) At any time and from time to time between, April 23, 2003 and
April 22, 2006, (the expiration of four (4) years from the Closing Date, i.e.
the "Expiration Date") inclusive, the Holder shall have the right to purchase
Shares hereunder at the Exercise Price.

          (c) After the Expiration Date, the Holder shall have no right to
purchase all or any portion of the Shares hereunder.

     2. (a) The rights represented by the Placement Agent's Warrant may be
exercised at any time within the periods above specified, in whole or in part,
by (i) the surrender of the Placement Agent's Warrant (with the purchase form at
the end hereof properly executed) at the principal executive office of the
Company (or such other office or agency of the Company as it may designate by
notice in writing to the Holder at the address of the Holder appearing on the
books of the Company); (ii) payment to the Company of the Exercise Price then in
effect for the number of Shares specified in the above-mentioned purchase form
together with applicable stock transfer taxes, if any; and (iii) delivery to the
Company of a duly executed agreement signed by the person(s) designated in the
purchase form to the effect that such person(s) agree(s) to be bound by the
provisions of Section 6 and subsections (b), (c) and (d) of Section 7 hereof.
The Placement Agent's Warrant shall be deemed to have been exercised, in whole
or in part to the extent specified, immediately prior to the close of business
on the date the Placement Agent's Warrant is surrendered and payment is made in
accordance with the foregoing provisions of this Section 2, and the person or
persons in whose name or names the certificates for the Shares shall be issuable
upon such exercise shall become the holder or holders of record of such Shares
at that time and date. The Shares and the certificates for the Shares so
purchased shall be delivered to the Holder within a reasonable time, not
exceeding ten (10) business days, after the rights represented by this Placement
Agent's Warrant shall have been so exercised.

          (b) Notwithstanding anything to the contrary contained in Section
2(a), the Holder may elect to exercise this Placement Agent's Warrant in whole
or in part on a "cashless exercise basis" by receiving Shares equal to the value
(as determined below) of this Placement Agent's Warrant, or any part hereof,
upon surrender of the Placement Agent's Warrant at the principal office of the
Company together with notice of such


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election in which event the Company shall issue to the Holder a number of Shares
computed using the following formula:

                                   X = Y(A-B)
                                        A

         Where             X =  the number of Shares to be issued to the Holder;

                           Y =  the number of Shares issuable upon exercise
                                of this Placement Agent's Warrant;

                           A    = the current fair market value of one share
                                of Common Stock (determined in the same
                                manner as the "current market price per
                                share of Common Stock" is to be determined
                                pursuant to Section 8(e) of this Placement
                                Agent's Warrant);

                           B =  the Exercise Price.

     3. (a) The Placement Agent's Warrant shall not be sold, transferred,
assigned, or hypothecated for a period of one year commencing on the Closing
Date except that it may be transferred to successors of the Holder.

          (b) Any transfer of this Placement Agent's Warrant shall be effected
by the Holder by (i) executing the form of assignment at the end hereof and (ii)
surrendering the Placement Agent's Warrant for cancellation at the office or
agency of the Company referred to in Section 2 hereof, accompanied by (x) a
written instrument of transfer in form reasonably satisfactory by the Company,
duly executed by the registered Holder thereof or by the duly appointed legal
representative thereof or by a duly authorized attorney-in-fact, (y) a
certificate (signed by an officer of the Holder if the Holder is a corporation)
stating that each transferee is a permitted transferee under this Section 3; and
(z) an opinion of counsel, reasonably satisfactory in form and substance to the
Company, to the effect that this Placement Agent's Warrant or the Shares, as
applicable, may be sold or otherwise transferred without registration under the
Securities Act of 1933, as amended (the "Act"). Upon original issuance thereof,
and until such time as the same shall have been registered under the Act or sold
pursuant to Rule 144 promulgated thereunder (or any similar rule or regulation),
each certificate representing the Placement Agent's Warrant or any part thereof
shall bear the following legend, unless in the opinion of counsel to the Company
such legend is no longer required by the Securities Act:

         THIS WARRANT AND THE SHARES OF COMMON STOCK THAT ARE ISSUABLE UPON
         EXERCISE OF THE WARRANT MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
         OTHERWISE TRANSFERRED UNLESS SUCH TRANSFER IS REGISTERED OR QUALIFIED
         UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND APPLICABLE STATE
         SECURITIES LAWS OR UNLESS THE CORPORATION RECEIVES AN OPINION OF


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<PAGE>

         COUNSEL OR OTHER EVIDENCE REASONABLY SATISFACTORY TO IT TO THE EFFECT
         THAT SUCH REGISTRATION AND QUALIFICATION ARE NOT REQUIRED.

Upon any transfer of this Placement Agent's Warrant or any part thereof in
accordance with the first sentence of this Section 3(b), the Company shall
issue, in the name or names specified by the Holder (including the Holder), a
new Placement Agent's Warrant or Warrants of like tenor and representing in the
aggregate rights to purchase the same number of Shares as are purchasable
hereunder at such time.

          (c) Any attempted transfer of this Placement Agent's Warrant or any
part thereof in violation of this Section 3 shall be null and void ab initio.

     4. The Company covenants and agrees that all Shares which may be purchased
hereunder will, upon issuance and delivery against payment therefor of the
requisite purchase price, be duly and validly issued, fully paid and
nonassessable. The Company further covenants and agrees that, during the periods
within which the Placement Agent's Warrant may be exercised, the Company will at
all times have authorized and reserved a sufficient number of shares of its
Common Stock to provide for the exercise of the Placement Agent's Warrant.

     5. The Placement Agent's Warrant shall not entitle the Holder to any voting
rights or other rights, including without limitation notice of meetings of other
actions or receipt of dividends, as a stockholder of the Company.

     6. (a) Except as provided in Section 6(b), the Company shall advise the
Holder or its permitted transferee, whether the Holder holds the Placement
Agent's Warrant or has exercised the Placement Agent's Warrant and holds Shares,
by written notice at least four weeks prior to the filing of any new
registration statement thereto under the Act, covering any equity securities of
the Company, for its own account or for the account of others, except for any
registration statement filed on Form S-4 or S-8 (or other comparable form), and
will, during the three (3) year period from the First Anniversary Date, upon the
request of the Holder, include in any such new registration statement (the
"Registration Statement") such information as may be required to permit a public
offering of, all or any of the Shares underlying the Placement Agent's Warrant
(the "Registrable Securities").

          (b) At any time during the three (3) year period beginning on the
First Anniversary Date, a 50% Holder (as defined below) may request, on one
occasion, that the Company register under the Act any and all of the Registrable
Securities held by such 50% Holder, at the Company's expense (except as provided
below). Upon the receipt of any such notice, the Company will promptly, but no
later than four weeks after receipt of such notice, file a post-effective
amendment to any existing registration statement or a new registration statement
pursuant to the Act (such post-effective amendment or new registration
statement, a "Demand Registration Statement"), so that such designated
Registrable Securities may be publicly sold under the Act as promptly as
practicable thereafter and the Company shall, subject to Section 6(h), use
reasonable best efforts to


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<PAGE>

cause such Demand Registration Statement to become effective (including the
taking of such reasonable steps as are necessary to obtain the removal of any
stop order) within 120 days after the receipt of such notice, provided, that
such 50% Holder shall furnish the Company with appropriate information in
connection therewith as the Company may reasonably request in writing. The 50%
Holder may, at its option, request the registration of any of Registrable
Securities in a registration statement made by the Company as contemplated by
Section 6(a) or in connection with a request made pursuant to this Section 6(b),
in either case prior to acquisition of the Shares issuable upon exercise of the
Placement Agent's Warrant. Subject to Section 6(h), within ten days after
receiving any such notice pursuant to this Section 6(b), the Company shall give
notice to any other Holders of the Placement Agent's Warrant, advising that the
Company is proceeding with such Demand Registration Statement and offering to
include therein, pursuant to Section 6(a), the Shares underlying that part of
the Placement Agent's Warrant held by the other Holders, provided that they
shall furnish the Company with such appropriate information (relating to the
intentions of such Holders) in connection therewith as the Company shall
reasonably request in writing.

          (c) The term "50% Holder" as used in this Section 6 shall mean the
Holder(s) of at least 50% of the Placement Agent's Warrant and/or the Shares
underlying the Placement Agent's Warrant upon the initial issuance of the
Placement Agent's Warrant, as the same may have been adjusted pursuant to
Section 8.

          (d) For so long as the Registrable Securities included in any
Registration Statement or Demand Registration Statement remain unsold, but in
any event not longer than 270 days after the date of effectiveness of such
Registration Statement or Demand Registration Statement (plus the number of
days, if any, that such Registration Statement or Demand Registration Statement
has been suspended pursuant to the provisions of Section 6(h)), the Company
shall, subject to Section 6(h), (i) maintain the effectiveness of such
Registration Statement or Demand Registration Statement; (ii) timely file all
reports required under the Securities Exchange Act of 1934, as amended, and the
rules and regulations of the Securities and Exchange Commission (the
"Commission") thereunder; (iii) file such post-effective amendments to the
Registration Statement or Demand Registration Statement as may be necessary so
that the Registration Statement or Demand Registration Statement does not
contain any misstatement of a material fact or omit to state any material fact
required to make the statements therein not misleading; (iv) supply prospectuses
and such other documents as any Holder whose Registrable Securities are included
in such Registration Statement or Demand Registration Statement may reasonably
request in order to facilitate the public sale or other disposition of such
Registrable Securities; (v) use its reasonable best efforts to register and
qualify any of the Registrable Securities for sale in such jurisdictions within
the United States (x) as any such Holder designates and (y) with respect to
which the Company obtained a qualification in connection with its initial public
offering, provided that the nothing in this clause (v) shall require the Company
to qualify to do business as a foreign corporation or to file a general consent
to service of process in any jurisdiction in which it is not otherwise so
qualified or required to file such a consent at the time; and (vi) do any and
all other acts and things which may be necessary or desirable to enable any such
Holder to consummate the public sale or other disposition of the Registrable


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<PAGE>

Securities included in the Registration Statement or Demand Registration
Statement, all at no expense to such Holder or the Placement Agent (except as
provided in the immediately following sentence). All costs and expenses in
connection with any Registration Statement or Demand Registration Statement
shall be borne by the Company, except that the Holder(s) shall bear the fees of
their own counsel and any other advisors retained by them and any underwriting
discounts or sales or other commissions applicable to any of the Registrable
Securities sold by them. In connection with any Registration Statement or Demand
Registration Statement, the Company shall furnish indemnification in the manner
provided in Section 7 hereof, and each Holder whose Registrable Securities are
included therein shall furnish information and indemnification in the manner
provided in Section 7. Subject to Section 6(g), the Company shall have the right
to include additional shares of Common Stock to be issued and sold by the
Company in any Demand Registration Statement.

          (e) Notwithstanding the foregoing set forth in this Section 6, the
Company shall not be required to include in any Registration Statement or any
Demand Registration Statement any Registrable Securities which in the opinion of
counsel to the Company (which opinion is reasonably acceptable to counsel to the
Placement Agent) would be saleable immediately without restriction or limitation
under Rule 144 (or its successor) if the Placement Agent's Warrant was exercised
pursuant to Section 2(b) herein.

          (f) If any registration pursuant to this Section 6 is in the form of
an underwritten offering, the Company will select and obtain the investment
banker or investment bankers and manager or managers that will administer the
offering. The Company shall (together with each Holder whose Registrable
Securities are included in such offering) enter into an underwriting agreement
in customary form with the managing underwriter selected for such underwriting.
If any Holder disapproves of the terms of the underwriting, it may elect to
withdraw therefrom by written notice to the Company and the managing
underwriter, and upon such withdrawal the original request of such Holder to
cause Registrable Securities to be registered shall not be deemed to constitute
a request for registration pursuant to Section 6(b), provided that the
withdrawal of one or more Holders shall not affect the determination of whether
any request made pursuant to Section 6(b) was made by a 50% Holder, and provided
further that if all Holders who have requested inclusion of their shares in a
Demand Registration pursuant to Section 6(b) withdraw their Registrable
Securities, then, notwithstanding anything to the contrary in this Placement
Agent's Warrant, any Holders who request registration of Registrable Securities
pursuant to Section 6(b) in the future shall be responsible for and pay all
expenses incurred by the Company in connection with such future registration.

          (g) (i) In the event that any registration pursuant to Section 6(a)
shall be in connection with an underwritten offering, and the managing
underwriter determines in good faith and advises in writing that the number of
Registrable Securities to be included in such offering, together with the number
of shares of Common Stock to be included in the Registration Statement by the
Company or other holders of the Company's securities with the right to request
inclusion in the Registration Statement, if any, exceeds the number of shares of
Common Stock that it is advisable to offer and sell at such time


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<PAGE>

or would interfere with the successful marketing of the Common Stock covered by
the Registration Statement, then priority for including shares of Common Stock
in the Registration Statement, up to the number advised by the managing
underwriter, shall be allocated first, to the Company and each other person who
has requested inclusion of shares of Common Stock pursuant to a "demand"
registration right, pro rata in proportion to the respective number of shares of
Common Stock to be included by them, and second, to the extent of any remaining
capacity as advised by the managing underwriter, to the Holders requesting
registration of their Registrable Securities and each other person who has
requested inclusion of shares of Common Stock pursuant to a "piggyback"
registration right, pro rata in proportion to the respective number of shares of
Common Stock (including Registrable Securities) to be included by them. (ii) In
the event that any registration pursuant to Section 6(b) shall be in connection
with an underwritten offering, and the managing underwriter determines in good
faith and advises in writing that the number of Registrable Securities to be
included in such offering, together with the number of shares of Common Stock to
be included in the Demand Registration Statement by the Company or other holders
of the Company's securities with the right to request inclusion in the Demand
Registration Statement, if any, exceeds the number of shares of Common Stock
that it is advisable to offer and sell at such time or would interfere with the
successful marketing of the Common Stock covered by the Demand Registration
Statement, then priority for including shares of Common Stock in the Demand
Registration Statement, up to the number advised by the managing underwriter,
shall be allocated first, to the 50% Holder and each other person who has
requested inclusion of shares of Common Stock pursuant to a "demand"
registration right, pro rata in proportion to the respective number of shares of
Common Stock to be included by them, and second, to the extent of any remaining
capacity as advised by the managing underwriter, to the Company and each other
person (including any Holder who is not a 50% Holder and who requests inclusion
of Registrable Securities in the Demand Registration Statement pursuant to
Section 6(a)) who has requested inclusion of shares of Common Stock pursuant to
a "piggyback" registration right, pro rata in proportion to the respective
number of shares of Common Stock (including Registrable Securities) to be
included by them.

          (h) In any registration initiated by the Company or by any person
having "demand" registration rights (other than a 50% Holder exercising such
rights pursuant to Section 6(b)) in which Holders request inclusion of their
Registrable Securities pursuant to Section 6(a), if at any time after giving
notice of its intention to register securities and prior to the effective date
of the Registration Statement the Company or such other person shall determine
for any reason not to register or to delay registration of it securities, the
Company may, at its election, give written notice of such determination to each
Holder that has requested inclusion of Registrable Securities in the
Registration Statement and (x) in the case of a determination not to register,
shall be relieved of its obligation to register any Registrable Securities in
connection with such registration and (y) in the case of a determination to
delay registering, shall be permitted to delay registering any Registrable
Securities for the same period as the delay in registering such other
securities. If (i) at any time when a prospectus relating to Registrable
Securities is required to be delivered under the Act, the Company discovers
that, or any event occurs as a result of which, the prospectus (including any
supplement


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thereto) included in any Registration Statement or Demand Registration
Statement, as then in effect, includes an untrue statement of a material fact or
omits to state any material fact required to be stated therein or necessary to
make the statements therein, in the light of the circumstances under which they
were made, not misleading, or (ii) the Commission issues any stop order
suspending the effectiveness of any Registration Statement or proceedings are
initiated or threatened for that purpose, then the Company shall promptly
deliver a written notice to such effect to each Holder whose Registrable
Securities are included in such Registration Statement or Demand Registration
Statement, and each such Holder shall immediately upon receipt of such notice
discontinue its disposition of Registrable Securities pursuant to such
Registration Statement or Demand Registration Statement until its receipt of the
copies of the supplemented or amended prospectus contemplated by the immediately
following sentence and, if so directed by the Company, shall deliver to the
Company (at the Company's expense) all copies, other than permanent file copies,
then in such Holder's possession of the prospectus or prospectus supplement
relating to such Registrable Securities current at the time of receipt of such
notice. As promptly as practicable following the event or discovery referred to
in clause (i) of the immediately preceding sentence, the Company shall prepare
and furnish to the Holders whose Registrable Securities are included in such
Registration Statement or Demand Registration Statement a reasonable number of
copies of an amendment or supplement of such prospectus so that, as thereafter
delivered to purchasers of such Registrable Securities, such prospectus shall
not include an untrue statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements therein,
in the light of the circumstances under which they were made, not misleading.
Notwithstanding anything to the contrary in this Section 6 if the filing or
maintenance of any Registration Statement or Demand Registration Statement would
require the Company to make a disclosure that would, in the reasonable judgment
of the Company's Board of Directors, have a material adverse effect on the
business, operations, properties, prospects or financial condition of the
Company or on pending or imminent transactions, the Company shall have the
right, exercisable for a period not to exceed in the aggregate 45 consecutive
calendar days in any period of twelve consecutive months (the "Blackout Period")
upon written notice to the Holders, to delay the filing of any Registration
Statement or Demand Registration Statement or of any amendment thereto, to
suspend its obligation to maintain the effectiveness of any Registration
Statement or Demand Registration Statement and to suspend the use of any
prospectus or prospectus supplement in connection with any Registration
Statement or Demand Registration Statement. Each Holder agrees that upon receipt
of any such notice from the Company, it shall immediately cease all efforts to
dispose of Registrable Securities pursuant to such Registration Statement or
Demand Registration Statement until such time as the Company shall notify it of
the end of such restrictions or, if earlier, the expiration of the Blackout
Period.

     7. (a) Whenever pursuant to Section 6 a Registration Statement or Demand
Registration Statement relating to any Shares issued upon exercise of the
Placement Agent's Warrant is filed under the Act, amended or supplemented, the
Company will indemnify and hold harmless each Holder of the securities covered
by such Registration Statement or Demand Registration Statement, amendment or
supplement (such Holder being hereinafter called the "Distributing Holder"), and
each person, if any, who controls (within the meaning of the Act) the
Distributing Holder, and each underwriter (within the meaning of the Act) of
such securities and each person, if any, who controls


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(within the meaning of the Act) any such underwriter, against any losses,
claims, damages or liabilities, joint or several, to which the Distributing
Holder, any such controlling person or any such underwriter may become subject,
under the Act or otherwise, insofar as such losses, claims, damages or
liabilities, or actions in respect thereof, arise out of or are based upon any
untrue statement or alleged untrue statement of any material fact contained in
any such Registration Statement or Demand Registration Statement as declared
effective or any final prospectus constituting a part thereof or any amendment
or supplement thereto, or arise out of or are based upon the omission or the
alleged omission to state therein a material fact required to be stated therein
or necessary to make the statements therein not misleading and will reimburse
the Distributing Holder or such controlling person or underwriter for any legal
or other expense reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability or action; provided, however,
that the Company will not be liable in any such case to the extent that any such
loss, claim, damage or liability arises out of or is based upon an untrue
statement or alleged untrue statement or omission or alleged omission made in
said Registration Statement or Demand Registration Statement, said preliminary
prospectus, said final prospectus or said amendment or supplement in reliance
upon and in conformity with written information furnished by such Distributing
Holder or any other Distributing Holder for use in the preparation thereof and
provided further, that the indemnity agreement provided in this Section 7(a)
with respect to any preliminary prospectus shall not inure to the benefit of any
Distributing Holder, controlling person of such Distributing Holder, underwriter
or controlling person of such underwriter from whom the person asserting any
losses, claims, charges, liabilities or litigation based upon any untrue
statement or alleged untrue statement of a material fact or omission or alleged
omission to state therein a material fact, received such preliminary prospectus,
if a copy of the prospectus in which such untrue statement or alleged untrue
statement or omission or alleged omission was corrected has not been sent or
given to such person within the time required by the Act and the rules and
regulations of the Commission thereunder.

          (b) The Distributing Holder will indemnify and hold harmless the
Company, each of its directors, each of its officers who have signed said
Registration Statement or Demand Registration Statement and such amendments and
supplements thereto, and each person, if any, who controls the Company (within
the meaning of the Act) against any losses, claims, damages or liabilities,
joint or several, to which the Company or any such director, officer or
controlling person may become subject, under the Act or otherwise, insofar as
such losses, claims, damages or liabilities, or actions in respect thereof,
arise out of or are based upon any untrue or alleged untrue statement of any
material fact contained in said Registration Statement or Demand Registration
Statement, said preliminary prospectus, said final prospectus, or said amendment
or supplement, or arise out of or are based upon the omission or the alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, in each case to the
extent, but only to the extent, that such loss, claim, damage or liability
arises out of or is based upon an untrue statement or alleged untrue statement
or omission or alleged omission made in said Registration Statement or Demand
Registration Statement, said preliminary prospectus, said final prospectus or
said


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amendment or supplement in reliance upon and in conformity with written
information furnished by such Distributing Holder for use in the preparation
thereof; and will reimburse the Company or any such director, officer or
controlling person for any legal or other expenses reasonably incurred by them
in connection with investigating or defending any such loss, claim, damage,
liability or action.

          (c) Promptly after receipt by an indemnified party under this Section
7 of notice of the commencement of any action, such indemnified party will, if a
claim in respect thereof is to be made against an indemnifying party under this
Section 7, notify the indemnifying party in writing of the commencement thereof,
but the omission so to notify the indemnifying party will not relieve it from
any liability which it may have to any indemnified party for indemnity or
contribution to the extent it is not prejudiced as a proximate result of such
failure. In case any such action is brought against any indemnified party, and
such indemnified party seeks or intends to seek indemnity from an indemnifying
party, the indemnifying party will be entitled to participate in, and, to the
extent that it shall elect, jointly with any other indemnifying party similarly
notified, by written notice delivered to the indemnified party promptly after
receiving the aforesaid notice from such indemnified party, to assume the
defense thereof with counsel reasonably satisfactory to such indemnified party;
provided, however, if the defendants in any such action include both the
indemnified party and the indemnifying party and the indemnified party shall
have reasonably concluded that a conflict may arise between the positions of the
indemnifying party and the indemnified party in conducting the defense of any
such action or that there may be legal defenses available to it and/or other
indemnified parties which are different from or additional to those available to
the indemnifying party, the indemnified party or parties shall have the right to
select separate counsel to assume such legal defenses and to otherwise
participate in the defense of such action on behalf of such indemnified party or
parties. Upon receipt of notice from the indemnifying party to such indemnified
party of such indemnifying party's election so to assume the defense of such
action and approval by the indemnified party of counsel (which approval shall
not be unreasonably withheld or delayed), the indemnifying party will not be
liable to such indemnified party under this Section 7 for any legal or other
expenses subsequently incurred by such indemnified party in connection with the
defense thereof unless: (i) the indemnified party shall have employed separate
counsel in accordance with the proviso to the next preceding sentence (it being
understood, however, that the indemnifying party shall not be liable for the
expenses of more than one separate counsel (together with local counsel),
representing the indemnified parties who are parties to such action); (ii) the
indemnifying party shall not have employed counsel satisfactory to the
indemnified party to represent the indemnified party within a reasonable time
after notice of commencement of the action; or (iii) the indemnifying party has
authorized the employment of counsel for the indemnified party satisfactory to
the indemnified party at the expense of the indemnifying party, in each of which
cases the fees and expenses of counsel shall be at the expense of the
indemnifying party.

          (d) The indemnifying party under this Section 7 shall not be liable
for any settlement of any proceeding effected without its written consent, which
consent shall not be unreasonably withheld or delayed, but if settled with such
consent or if there be a final judgment for the plaintiff, the indemnifying
party agrees to indemnify the


                                       10

<PAGE>

indemnified party against any loss, claim, damage, liability or expense by
reason of such settlement or judgment. No indemnifying party shall, without the
prior written consent of the indemnified party, effect any settlement,
compromise or consent to the entry of judgment in any pending or threatened
action, suit or proceeding in respect of which any indemnified party is or could
have been a party and indemnity was or could have been sought hereunder by such
indemnified party, unless such settlement, compromise or consent includes: (i)
an unconditional release of such indemnified party from all liability on claims
that are the subject matter of such action, suit or proceeding; and (ii) does
not include a statement as to or an admission of fault, culpability or a failure
to act by or on behalf of any indemnified party.

          (e) Any losses, claims, damages, liabilities or expenses for which an
indemnified party is entitled to indemnification or contribution under this
Section 7 shall be paid by the indemnifying party to the indemnified party as
such losses, claims, damages, liabilities or expenses are incurred, but in all
cases, no later than forty-five (45) days after invoice to the indemnifying
party.

          (f) If the indemnification provided for in this Section 7 is
unavailable to or insufficient to hold harmless an indemnified party under
Section 7(a) or 7(b) above in respect of any losses, claims, damages or
liabilities (or actions or proceedings in respect thereof) then each
indemnifying party shall contribute to the aggregate amount paid or payable by
such indemnified party in such proportion as is appropriate to reflect the
relative fault of such indemnifying party on the one hand and the Distributing
Holder on the other in connection with the statements or omissions which
resulted in such losses, claims, damages or liabilities (or actions or
proceedings in respect thereof), as well as any other relevant equitable
considerations. The relative fault shall be determined by reference to, among
other things, whether the untrue or alleged untrue statement of a material fact
or the omission or alleged omission to state a material fact relates to
information supplied by the Company or the "control" stockholders on the one
hand or the Distributing Holder on the other and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission.

     The Company and each Distributing Holder agree that it would not be just
and equitable if contributions pursuant to this Section 7(f) were determined by
pro rata allocation or by any other method of allocation which does not take
account of the equitable considerations referred to above in this Section 7(f).
The amount paid or payable by an indemnified party as a result of the losses,
claims, damages or liabilities (or actions or proceedings in respect thereof)
referred to above in this Section 7(f) shall be deemed to include any legal or
other expenses reasonably incurred by such indemnified party in connection with
investigating or defending any such action or claim. Notwithstanding the
provisions of this Section 7(f): (i) each Distributing Holder shall not be
required to contribute any amount in excess of the amount of proceeds received
by such Holder from sale(s) of such Holder's Shares pursuant to the Registration
Statement or Demand Registration Statement; and (ii) no person guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the Act)
shall be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation.


                                       11

<PAGE>

     8. The Exercise Price in effect at the time and the number and kind of
securities purchasable upon the exercise of the Warrant shall be subject to
adjustment from time to time upon the happening of certain events as follows:

          (a) In case the Company shall (i) declare a dividend or make a
distribution on its outstanding shares of Common Stock in shares of Common
Stock, (ii) subdivide or reclassify its outstanding shares of Common Stock into
a greater number of shares, (iii) combine or reclassify its outstanding shares
of Common Stock into a smaller number of shares, or (iv) enter into any
transaction whereby the outstanding shares of Common Stock of the Company are at
any time changed into or exchanged for a different number or kind of shares or
other security of the Company or of another corporation through reorganization,
merger, consolidation, liquidation or recapitalization, then appropriate
adjustments in the number of Shares (or other securities for which such Shares
have previously been exchanged or converted) subject to this Placement Agent's
Warrant shall be made and the Exercise Price in effect at the time of the record
date for such dividend or distribution or of the effective date of such
subdivision, combination, reclassification, reorganization, merger,
consolidation, liquidation or recapitalization shall be proportionately adjusted
so that the Holder of this Placement Agent's Warrant exercised after such date
shall be entitled to receive the aggregate number and kind of shares of Common
Stock which, if this Placement Agent's Warrant had been exercised by such Holder
immediately prior to such date, the Holder would have been entitled to receive
upon such dividend, distribution, subdivision, combination, reclassification,
reorganization, merger, consolidation, liquidation or recapitalization. For
example, if the Company declares a 2 for 1 stock distribution and the Exercise
Price hereof immediately prior to such event was $9.80 per Share and the number
of Shares issuable upon exercise of this Placement Agent's Warrant was 140,000,
the adjusted Exercise Price immediately after such event would be $4.90 per
Share and the adjusted number of Shares issuable upon exercise of this Placement
Agent's Warrant would be 280,000. Such adjustment shall be made successively
whenever any event listed above shall occur.

          (b) In case the Company shall fix a record date for the issuance of
rights or warrants to all holders of its Common Stock entitling them to
subscribe for or purchase shares of Common Stock (or securities convertible into
Common Stock) at a price (the "Subscription Price") (or having a conversion
price per share) less than the current market price per share of Common Stock
basis as determined pursuant to Section 8(e) on such record date, the Exercise
Price shall be adjusted so that the same shall equal the price determined by
multiplying the same by a fraction, the numerator of which shall be the sum of
the number of shares of Common Stock outstanding on the record date mentioned
below and the number of additional shares of Common Stock which the aggregate
offering price of the total number of shares of Common Stock so offered (or the
aggregate conversion price of the convertible securities so offered) would
purchase at the current market price per share of Common Stock on such record
date, and the denominator of which shall be the sum of the number of shares of
Common Stock outstanding on the record date mentioned below and the number of
additional shares of Common Stock offered for subscription or purchase (or into
which the convertible securities so offered are convertible). Such adjustment
shall be made successively whenever such rights or warrants are issued and shall
become effective immediately after


                                       12

<PAGE>

the record date for the determination of stockholders entitled to receive such
rights or warrants; and to the extent that shares of Common Stock are not
delivered (or securities convertible into Common Stock are not delivered) after
the expiration of such rights or warrants the Exercise Price shall be readjusted
to the Exercise Price which would then be in effect had the adjustments made
upon the issuance of such rights or warrants been made upon the basis of
delivery of only the number of shares of Common Stock (or securities convertible
into Common Stock) actually delivered. This Section 8(b) shall not apply to the
occurrence of a "Distribution Date" under the Rights Agreement.

          (c) In case the Company shall hereafter distribute to all holders of
its Common Stock evidences of its indebtedness or assets (excluding cash
dividends or distributions and dividends or distributions referred to in Section
8(a) above) or subscription rights or warrants (excluding those referred to in
Section 8(b) above), then in each such case the Exercise Price shall be adjusted
by multiplying the same, by a fraction, the numerator of which shall be the
total number of shares of Common Stock then outstanding multiplied by the
current market price per share of Common Stock (as defined in Section 8(e)
below), less the fair market value (as determined by the Company's Board of
Directors) of said assets, or evidences of indebtedness so distributed or of
such rights or warrants, and the denominator of which shall be the total number
of shares of Common Stock outstanding multiplied by such current market price
per share of Common Stock. Such adjustment shall be made whenever any such
distribution is made and shall become effective immediately after the record
date for the determination of stockholders entitled to receive such distribution
and to the extent that any subscription rights or warrants are not exercised
before the expiration of such rights or warrants the Exercise Price shall be
readjusted to the Exercise Price which would then be in effect had the
adjustments made upon the issuance of such rights or warrants been made upon the
basis of delivery of only the number of rights or warrants actually exercised.
This Section 8(c) shall not apply to the occurrence of a "Distribution Date"
under the Rights Agreement.

          (d) Whenever the Exercise Price payable upon exercise of the Placement
Agent's Warrant is adjusted pursuant to Sections (a), (b) or (c) above, the
number of Shares purchasable upon exercise of this Placement Agent's Warrant
shall simultaneously be adjusted by multiplying the number of Shares issuable
upon exercise of this Placement Agent's Warrant by the Exercise Price in effect
immediately prior to such adjustment and dividing the product so obtained by the
Exercise Price, as adjusted.

          (e) For the purpose of any computation under Subsection (c) above, the
current market price per share of Common Stock at any date shall be deemed to be
the closing price on the Trading Day immediately preceding the date as of which
the current market price is being determined, provided that if the Common Stock
is not then listed on any market or exchange, then the current market price
shall be the average of the closing bid prices for the Common Stock on the OTC
Bulletin Board, or, if such is not available, the Pink Sheets LLC (formerly the
National Quotation Bureau), or otherwise the average of the closing bid prices
for the Common Stock quoted by two market-makers of the Common Stock, or
otherwise such Market Price shall be the fair market value of one share of
Common Stock as reasonably determined in good faith by the Corporation and


                                       13

<PAGE>

the Holders. "Trading Day" shall mean any day on which the principal United
States securities exchange or trading market on which the Common Stock is listed
or traded (the "Principal Market") as reported by Bloomberg Financial Markets
("Bloomberg's") is open for trading. "Closing price" shall mean the last sale
price for the Common Stock on the Principal Market on any particular Trading
Day.

          (f) No adjustment in the Exercise Price shall be required unless such
adjustment would require an increase or decrease of at least five cents ($0.05)
in such price; provided, however, that any adjustments which may by reason of
this Section 8(f) are not required to be made shall be carried forward and taken
into account in any subsequent adjustment required to be made hereunder. All
calculations under this Section 8 shall be made to the nearest cent or to the
nearest one-hundredth of a share, as the case may be. Anything in this Section 8
to the contrary notwithstanding, the Company shall be entitled, but shall not be
required, to make such changes in the Exercise Price, in addition to those
required by this Section 8, as it shall determine, in its sole discretion, to be
advisable in order that any dividend or distribution in shares of Common Stock,
or any subdivision, reclassification or combination of Common Stock, hereafter
made by the Company shall not result in any Federal income tax liability to the
holders of the Common Stock or securities convertible into Common Stock.

          (g) Whenever the Exercise Price is adjusted, as herein provided, the
Company shall promptly cause a notice setting forth the adjusted Exercise Price
and adjusted number of Shares issuable upon exercise of the Placement Agent's
Warrant to be mailed to the Holder, at its address set forth herein, and shall
cause a certified copy thereof to be mailed to the Company's transfer agent, if
any. The Company may retain a firm of independent certified public accountants
selected by the Board of Directors (who may be the regular accountants employed
by the Company) to make any computation required by this Section 8, and a
certificate signed by such firm shall be conclusive evidence of the correctness
of such adjustment.

          (h) In the event that at any time, as a result of an adjustment made
pursuant to the provisions of this Section 8, the Holder of the Placement
Agent's Warrant thereafter shall become entitled to receive any shares of the
Company other than Common Stock, thereafter the number of such other shares so
receivable upon exercise of the Placement Agent's Warrant shall be subject to
adjustment from time to time in a manner and on terms as nearly equivalent as
practicable to the provisions with respect to the Common Stock contained in
Sections 8(a) to (f), inclusive, above.

     9. This Agreement shall be governed by and in accordance with the laws of
the State of Delaware without regard to conflicts of laws principles thereof.

     10. In case of any consolidation of the Company with, or merger of the
Company into, any other entity, or in case of any sale or conveyance of all or
substantially all of the assets of the Company other than in connection with a
plan of complete liquidation of the Company at any time prior to the Expiration
Date, then as a condition of such consolidation, merger or sale or conveyance,
the Company shall give written notice of consolidation, merger, sale or
conveyance to the Holder and, from and


                                       14

<PAGE>

after the effective date of such consolidation, merger, sale or conveyance the
Placement Agent's Warrant shall represent only the right to receive the
consideration that would have been issuable in respect of the Shares underlying
the Placement Agent's Warrant in such consolidation, merger, sale or conveyance
had the Placement Agent's Warrant been exercised in full immediately prior to
such effective time and the Holder shall have no further rights under this
Placement Agent's Warrant other than the right to receive such consideration.


         [The remainder of this page has been intentionally left blank.]


                            [Signature Page Follows]


                                       15

<PAGE>

     IN WITNESS WHEREOF, the Company has caused this Placement Agent's Warrant
to be signed by its duly authorized officers under its corporate seal, and this
Placement Agent's Warrant to be dated April 23, 2002.

                                            BIOPURE CORPORATION


                                            By:   /s/ Paul A. Looney
                                                  ------------------------------
                                                  Paul A. Looney
                                                  ------------------------------
                                                  President
Attest:

/s/ Jane Kober
Jane Kober
----------------------------
Secretary


                                       16

<PAGE>

                                  PURCHASE FORM


                  (To be signed only upon exercise of Warrant)

     The undersigned, the holder of the foregoing Placement Agent's Warrant,
hereby irrevocably elects to exercise the purchase rights represented by such
Warrant for, and to purchase thereunder, _______________ Shares of Common Stock,
$0.001 par value per share (the "Shares"), of BIOPURE CORPORATION and either

 __
/_/   tenders herewith payment of the aggregate Exercise Price in respect of the
      Shares in full, in the amount of $_________; or

 __
/_/   elects pursuant to Section 2(b) of such Warrant to convert such Warrant
      into Common Stock on a cashless exercise basis; and

requests that the certificates for the Shares issued in the name(s) of, and
delivered to _________________, whose address(es) is (are):

Dated:                     ,
        -------------------  -------


                                          By:
                                               ---------------------------------

                                               ---------------------------------

                                               ---------------------------------
                                               Address

<PAGE>

                                  TRANSFER FORM


         (To be signed only upon transfer of Placement Agent's Warrant)

     For value received, the undersigned hereby sells, assigns, and transfers
unto ______________________________ the right to purchase Shares represented by
the foregoing Placement Agent's Warrant to the extent of __________ Shares, and
appoints _________________________ attorney to transfer such rights on the books
of Biopure Corporation, with full power of substitution in the premises. The
undersigned believes that each transferee is a permitted transferee under
Section 3 of the Placement Agent's Warrant.


Dated:                     ,
        -------------------  -------


                                          By:
                                               ---------------------------------

                                               ---------------------------------

                                               ---------------------------------
                                               Address


In the presence of:


--------------------------------