Sample Business Contracts

Independent Consulting and Project Agreement - Biogen Inc. and Kenneth Murray

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                                                     September 11, 1998

Sir Kenneth Murray
4 Mortonhall Road
Edinburgh EH9 2HW
Scotland, United Kingdom


Dear Ken:

         Your Independent Consulting and Project Agreement with Biogen, Inc.,
dated June 29, 1979, as previously amended (the "Agreement"), under which you
serve as a member of the Scientific Board of the Company expires on September
30, 1998. Biogen greatly values your input on the Scientific Board, and would
like to renew the Agreement for an additional three-year period commencing as of
September 30, 1998 and ending on September 30, 2001. The terms and conditions of
the Agreement will continue to apply during the renewal term except that
compensation for your services under the Agreement during the renewal term will
be as follows:

         1.  You will receive (i) a $20,000 per year retainer, (ii) $2,000 per
             day for attendance at Scientific Board meetings, plus reasonable
             travel and lodging expenses and (iii) $500 per day for time spent
             in Biogen=s laboratories.

         2.  Subject to approval by the Stock and Option Plan Administration
             Committee, on your renewal date, you will be granted an option to
             purchase 30,000 shares of Biogen Common Stock. The option will vest
             over three years (33-1/3% per year) and will be exercisable at a
             price equal to the average of the high and low sales prices on your
             renewal date.

         If you agree to renewal of the Agreement on these terms, please sign
both copies of this renewal letter and return one copy to the attention of Anne
Marie Cook, Associate General Counsel, Biogen, Inc., 14 Cambridge Center,
Cambridge, MA 02142.

<PAGE>   2

         We look forward to your continued participation on the Scientific

                                        Very truly yours,

                                        BIOGEN, INC.

                                           James R. Tobin
                                           President and Chief Executive

                                           Phillip A. Sharp, Ph.D.
                                           Chairman of Scientific Board

                                        AGREED TO AND ACCEPTED:

                                        Sir Kenneth Murray, Ph.D.