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California-Marina del Rey-4503 Glencoe Avenue Lease [Amendment No. 2] - EOP-Marina Business Center LLC and CancerVax Corp.

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                            SECOND AMENDMENT TO LEASE

         THIS SECOND AMENDMENT TO LEASE (the "Amendment") is made and entered
into as of the 4th day of September 2002, by and between EOP-MARINA BUSINESS
CENTER, L.L.C., A DELAWARE LIMITED LIABILITY COMPANY ("Landlord"), and CANCERVAX
CORPORATION, A DELAWARE CORPORATION ("Tenant").

                                    RECITALS

A.       Landlord (as successor in interest to Spieker Properties, L.P., a
         California limited partnership) and Tenant (as successor in interest to
         John Wayne Cancer institute, a non-profit corporation) are parties to
         that certain lease dated July 22, 1999, which lease has been previously
         amended by a letter agreement dated October 8, 1999 and First Amendment
         to Lease dated October 1, 2001 ("First Amendment") (collectively, the
         "Lease"). Pursuant to the Lease, Landlord has leased to Tenant space
         currently containing approximately 50,750 rentable square feet (the
         "Premises") described as Suite Nos. 100 and 150 on the 1st floor and
         mezzanine of the building commonly known as Marina Business Center
         located at 4503 Glencoe Avenue, Marina del Rey, California (the
         "Building").

B.       Tenant and Landlord mutually desire that the Lease be amended on and
         subject to the following terms and conditions.

         NOW, THEREFORE, in consideration of the mutual covenants and agreements
herein contained and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Landlord and Tenant agree as
follows:

I.       AMENDMENT. Effective as of the date hereof (unless different effective
         date(s) is/are specifically referenced in this Section), Landlord and
         Tenant agree that the Lease shall be amended in accordance with the
         following terms and conditions:

         A.       LETTER OF CREDIT. Landlord and Tenant acknowledge and agree
                  that effective as of the date hereof, the Letter of Credit
                  (Bank of America Irrevocable Standby Letter of Credit Number
                  3028429) in the amount of $778,000.00 held by Landlord as a
                  security for Tenant's obligations under the Lease shall be
                  reduced from $778,000.00 to $200,000.00. Except as modified
                  herein, the Letter of Credit shall be subject to the terms of
                  the Lease, as amended.

         B.       WORK LETTER. Effective as of the date hereof, the Work Letter
                  set forth in the Exhibit B of the First Amendment shall be
                  deleted in its entirety and of no further force or effect and
                  Tenant acknowledges and agrees that Tenant shall no longer
                  have any rights to the Allowance set forth therein. Any
                  construction, alterations or improvements to the Premises
                  shall be performed by Tenant at its sole cost and expense
                  using contractors selected by Tenant and approved by Landlord
                  and shall be governed in all respects by the terms of the
                  Lease.

II.      MISCELLANEOUS.

         A.       This Amendment and the attached exhibits, which are hereby
                  incorporated into and made a part of this Amendment, set forth
                  the entire agreement between the parties with respect to the
                  matters set forth herein. There have been no additional oral
                  or written representations or agreements. Under no
                  circumstances shall Tenant be entitled to any Rent abatement,
                  improvement allowance, leasehold improvements, or other work
                  to the Premises, or any similar economic incentives that may
                  have been provided Tenant in connection with entering into the
                  Lease, unless specifically set forth in this Amendment. Tenant
                  agrees that neither Tenant nor its agents or any other parties
                  acting on behalf of Tenant shall disclose any matters set
                  forth in this Amendment or disseminate or distribute any
                  information concerning the terms, details or conditions hereof
                  to any person, firm or entity without obtaining the express
                  written consent of Landlord.

         B.       Except as herein modified or amended, the provisions,
                  conditions and terms of the Lease shall remain unchanged and
                  in full force and effect.

         C.       In the case of any inconsistency between the provisions of the
                  Lease and this Amendment, the provisions of this Amendment
                  shall govern and control.

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<PAGE>

         D.       Submission of this Amendment by Landlord is not an offer to
                  enter into this Amendment but rather is a solicitation for
                  such an offer by Tenant. Landlord shall not be bound by this
                  Amendment until Landlord has executed and delivered the same
                  to Tenant.

         E.       The capitalized terms used in this Amendment shall have the
                  same definitions as set forth in the Lease to the extent that
                  such capitalized terms are defined therein and not redefined
                  in this Amendment.

         F.       Tenant hereby represents to Landlord that Tenant has dealt
                  with no broker in connection with this Amendment. Tenant
                  agrees to indemnify and hold Landlord, its members,
                  principals, beneficiaries, partners, officers, directors,
                  employees, mortgagee(s) and agents, and the respective
                  principals and members of any such agents (collectively, the
                  "Landlord Related Parties") harmless from all claims of any
                  brokers claiming to have represented Tenant in connection with
                  this Amendment. Landlord hereby represents to Tenant that
                  Landlord has dealt with no broker in connection with this
                  Amendment. Landlord agrees to indemnify and hold Tenant, its
                  members, principals, beneficiaries, partners, officers,
                  directors, employees, and agents, and the respective
                  principals and members of any such agents (collectively, the
                  "Tenant Related Parties") harmless from all claims of any
                  brokers claiming to have represented Landlord in connection
                  with this Amendment.

         G.       Each signatory of this Amendment represents hereby that he or
                  she has the authority to execute and deliver the same on
                  behalf of the party hereto for which such signatory is acting.

        IN WITNESS WHEREOF, Landlord and Tenant have duly executed this
Amendment as of the day and year first above written.

                             LANDLORD:

                             EOP-MARINA BUSINESS CENTER, L.L.C., A
                             DELAWARE LIMITED LIABILITY COMPANY

                             By: EOP Operating Limited Partnership, a Delaware
                                 limited partnership, its sole member

                                 By: Equity Office Properties Trust, a Maryland
                                     real estate investment trust, its general
                                     partner

                                     By: /s/ Frank R. Campbell
                                         ------------------------------------
                                     Name: Frank R. Campbell
                                     Title: Vice President

                             TENANT:

                             CANCERVAX CORPORATION, A DELAWARE CORPORATION

                             By: /s/ DAVID F. HALE
                                 ---------------------------------
                             Name: DAVID F. HALE
                             Title: PRESIDENT & CEO

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