Investors' Rights Agreement - Aastrom Biosciences Inc.
AASTROM BIOSCIENCES, INC.
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AMENDED AND RESTATED
INVESTORS' RIGHTS AGREEMENT
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April 7, 1992
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TABLE OF CONTENTS
Page
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SECTION 1 - Definitions.................................. 2
1.1 Certain Definitions.......................... 2
SECTION 2 - Restrictions on Transferability of
Securities; Compliance with Securities Act... 4
2.1 Restrictions on Transferability.............. 4
2.2 Restrictive Legend........................... 4
2.3 Notice of Proposed Transfers................. 5
2.4 Requested Registration....................... 6
2.5 Company Registration......................... 9
2.6 Registrations on Form S-3.................... 10
2.7 Expenses of Registration..................... 11
2.8 Registration Procedures...................... 12
2.9 Indemnification.............................. 12
2.10 Information by Holder........................ 14
2.11 Rule 144 Reporting........................... 14
2.12 "Market Stand-off" Agreement................. 15
2.13 Transfer of Registration Rights.............. 15
2.14 Suspension of Registration Rights............ 16
2.15 Certain Limitations in Connection with Future
Grants of Registration Rights............... 16
SECTION 3 - Affirmative Covenants........................ 16
3.1 Financial Information........................ 16
3.2 Other Information............................ 17
3.3 Inspection Rights............................ 18
3.4 Assignment of Rights to Information.......... 18
3.5 Confidentiality.............................. 18
3.7 Insurance 19
3.8 Board of Directors........................... 19
SECTION 4 - Right of First Refusal....................... 19
4.1 Right of First Refusal....................... 19
4.2 Waiver 20
SECTION 5 - University Warrants.......................... 21
5.1 Termination of Warrant Rights................ 21
SECTION 6 - Miscellaneous................................ 21
6.1 Amendment of Investors' Rights Agreement..... 21
6.2 Governing Law................................ 21
6.3 Successors and Assigns....................... 21
6.4 Notices 21
6.5 Delays or Omissions.......................... 22
6.6 Counterparts................................. 22
i.
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6.7 Severability................................. 22
6.8 Amendments................................... 22
ii.
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AASTROM BIOSCIENCES, INC.
AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT
THIS AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT (the "Agreement") is
entered into as of April 7, 1992, by and among AASTROM BioSciences, Inc., a
Michigan corporation formerly doing business as Ann Arbor Stromal, Inc. (the
"Company"), the investors listed on the Schedule of Investors attached hereto as
Exhibit A (individually, an "Investor" and collectively, the "Investors"), as
that exhibit may be amended from time to time, Stephen G. Emerson, Bernhard O.
Palsson and Michael F. Clarke (individually, a "Founder" and collectively, the
"Founders"), Dr. R. Douglas Armstrong ("Armstrong") and the Regents of the
University of Michigan, a constitutional corporation of the State of Michigan
(the "University"). For the purposes of this Agreement, the Founders and
Armstrong shall be collectively referred to as the "Option Holders."
RECITALS:
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A. The Company has issued shares of its Common Stock to the University and
has granted, and may, in the future, grant, stock options to the Founders
pursuant to the Company's Stock Option Plans.
B. The Company has issued two million five hundred thousand (2,500,000)
shares of its Series A Preferred Stock to certain of the Investors (the "Series
A Investors") pursuant to that certain Series A Preferred Stock Purchase
Agreement, dated as of August 17, 1989.
C. Pursuant to that certain Investors' Rights Agreement dated August 17,
1989 among the Company, the Series A Investors, the Founders and the University
(the "Investors' Rights Agreement"), the Company granted certain rights and the
parties made certain covenants with respect to the Series A Preferred Stock and
the Common Stock of the Company.
D. Since the execution of the Investors' Rights Agreement, the Company has
engaged Armstrong as its president and has granted, and may, in the future,
grant, stock options to Armstrong pursuant to the Company's Stock Option Plans.
E. Certain of the Investors (the "Series B Investors") are purchasing
concurrently herewith three million thirty thousand (3,030,000) shares of Series
B Preferred Stock and desire to obtain the same rights as are contained in the
Investors' Rights Agreement.
F. The Company, the Series A Investors, the Founders and the University
desire to grant to the Series B Investors and
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Armstrong the same rights as were granted under the Investors' Rights Agreement
and to amend and restate such Agreement.
G. The parties intend that this Agreement supersede the Investors' Rights
Agreement and, in that regard, the parties to the Investors' Rights Agreement
will waive certain rights contained in such Investors' Rights Agreement,
specifically (i) the right of first refusal to purchase on a pro rata basis the
shares of Series B Preferred Stock being issued concurrently herewith and (ii)
the right of the University to obtain certain warrants to purchase Common Stock.
AGREEMENT:
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NOW, THEREFORE, in consideration of the mutual promises, representations,
warranties, covenants, and conditions set forth in this Agreement and in the
agreements pursuant to which the Investors acquired their securities in the
Company, the parties mutually agree as follows:
SECTION 1
Definitions
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1.1 Certain Definitions. As used in this Agreement, the following terms
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shall have the following respective meanings:
"Commission" shall mean the Securities and Exchange Commission or any other
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federal agency at the time administering the Securities Act.
"Securities Act" shall mean the Securities Act of 1933, as amended, or any
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similar federal statute, and the rules and regulations of the Commission
thereunder, all as the same shall be in effect at the time.
"Exchange Act" shall mean the Securities Exchange Act of 1934, as amended,
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or any similar federal statute and the rules and regulations of the Commission
thereunder, all as the same shall be in effect at the time.
"Restricted Securities" shall mean the securities of the Company required
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to bear the legend set forth in Section 2.2 hereof.
"Shares" shall mean the securities of the Company held by the Investors as
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described on Exhibit A.
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"Options" shall mean any and all stock options granted to any of the
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Option Holders, as of the date hereof or thereafter, pursuant to any stock
option plan or agreement approved by the Company's Board of Directors.
"Registrable Securities" shall mean any shares of the Company's Common
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Stock (i) issued or issuable pursuant to the conversion of the Shares, (ii) held
as of August 17, 1989 by the University, (iii) issued or issuable upon exercise
of the Options, or (iv) issued as a dividend or other distribution with respect
to, or in exchange or in replacement of, the Shares or such Common Stock or
Preferred Stock, excluding in all cases, however (including exclusion from the
calculation of the number of outstanding Registrable Securities), any
Registrable Securities sold by a person in a transaction, including a
transaction pursuant to a registration statement under Section 2 hereof or a
transaction pursuant to Rule 144, in which such person's rights under Section 2
are not transferred.
The terms "register," "registered" and "registration" refer to a
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registration effected by preparing and filing a registration statement in
compliance with the Securities Act, and the declaration or ordering of the
effectiveness of such registration statement.
"Registration Expenses" shall mean all expenses incurred by the Company in
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complying with Sections 2.4, 2.5 and 2.6 hereof, including, without limitation,
all registration and filing fees, printing expenses, fees and disbursements of
counsel for the Company, reasonable fees and disbursements of a single special
counsel for the Holders, blue sky fees and expenses, and the expense of any
special audits incident to or required by any such registration other than a
registration pursuant to Section 2.4, in which event such special audit expenses
will be paid by the holders of the securities so registered pro rata on the
basis of the number of shares so registered, (but excluding the compensation of
regular employees of the Company which shall be paid in any event by the
Company).
"Holder" shall mean any holder of outstanding Registrable Securities or
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securities convertible into or exercisable for Registrable Securities.
"Initiating Holders" shall mean the holder or holders of fifty percent
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(50%) or more of the combination of the then outstanding Shares and Common Stock
issued upon conversion of the Shares.
"New Securities" shall mean any Common Stock or Preferred Stock of the
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Company, whether now authorized or not, and rights, options or warrants to
purchase said Common Stock or Preferred Stock, and securities of any type
whatsoever that are,
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or may become, convertible into said Common Stock or Preferred Stock; provided,
however, that "New Securities" does not include (i) securities issuable upon
conversion of or with respect to the Shares; (ii) securities offered to the
public pursuant to a registration statement filed under the Securities Act;
(iii) securities issued pursuant to the acquisition of another corporation by
the Company by merger, purchase of substantially all of the assets, or other
reorganization whereby the Company (or the Company's shareholders immediately
prior to such event) owns (or own, on a pro rata basis) not less than fifty-one
percent (51%) of the voting power of such corporation immediately after such
event; (iv) shares of the Company's Common Stock (or related options) issued to
employees, officers or directors of or consultants to the Company (including,
but not limited to, shares issued to the Option Holders) pursuant to any
employee stock offering, plan, or arrangement approved by the Board of
Directors; or (v) shares of the Company's Common Stock or Preferred Stock issued
in connection with any stock split, stock dividend, or recapitalization by the
Company.
SECTION 2
Restrictions on Transferability of
Securities; Compliance with Securities Act
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2.1 Restrictions on Transferability. The Shares, any Common Stock into
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which the Shares may be convertible, the Common Stock and Options held by the
Option Holders and the University shall not be transferable except upon the
conditions specified in this Agreement, which conditions are intended to insure
compliance with the provisions of the Securities Act, or, in the case of Section
2.12 hereof, to assist in an orderly distribution. Each Investor will cause any
proposed transferee of the Shares (or of the Common Stock into which the Shares
may be convertible) held by an Investor to agree to take and hold such
securities subject to the provisions and upon the conditions specified in this
Agreement. Each Option Holder and the University will cause any proposed
transferee of Common Stock held by an Option Holder or the University,
respectively, to agree to take and hold such securities subject to the
provisions and upon the conditions specified in this Agreement.
2.2 Restrictive Legend. Each certificate representing (i) the Shares,
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(ii) shares of the Company's Common Stock issued upon conversion of the Shares,
(iii) any securities issued in respect of the Shares or such Common Stock, or
(iv) shares of the Company's Common Stock, Preferred Stock or Options held by an
Option Holder or the University shall (unless otherwise permitted by the
provisions of Section 2.3 below) be stamped or otherwise imprinted with a legend
in the following form (in addition to any legend required under applicable state
securities laws):
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THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, HAVE BEEN ISSUED
PURSUANT TO A CLAIM OF EXEMPTION FROM THE REGISTRATION OR
QUALIFICATION PROVISIONS OF SUCH ACT AND APPLICABLE STATE SECURITIES
LAWS, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED,
EXCEPT AS PERMITTED PURSUANT TO 17 C.F. R SECTION 230.144, OR THERE IS
IN EFFECT A REGISTRATION STATEMENT UNDER SUCH ACT AND APPLICABLE STATE
SECURITIES LAWS COVERING SUCH SECURITIES, OR THE ISSUER RECEIVES AN
OPINION OF COUNSEL FOR THE HOLDER OF SUCH SECURITIES REASONABLY
SATISFACTORY TO THE ISSUER, STATING THAT SUCH SALE, TRANSFER,
ASSIGNMENT OR HYPOTHECATION IS EXEMPT FROM THE REGISTRATION,
QUALIFICATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SUCH ACT AND
APPLICABLE STATE SECURITIES LAWS.
SALE OR OTHER TRANSFER OF THE SECURITIES EVIDENCED BY THIS CERTIFICATE
IS ALSO RESTRICTED BY THE TERMS OF STOCK PURCHASE AGREEMENTS BETWEEN
THE ISSUER AND THE PURCHASERS LISTED THEREIN AND BY THE TERMS OF THAT
CERTAIN AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT BETWEEN THE
ISSUER AND THE OTHER PARTIES THERETO. COPIES OF SUCH DOCUMENTS MAY BE
OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE HOLDER OF THIS
CERTIFICATE TO THE SECRETARY OF THE ISSUER AT ITS PRINCIPAL EXECUTIVE
OFFICES.
2.3 Notice of Proposed Transfers. The holder of each certificate
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representing Restricted Securities by acceptance thereof agrees to comply in all
respects with the provisions of this Section 2.3. Prior to any proposed
transfer of any Restricted Securities unless there is in effect a registration
statement under the Securities Act covering the proposed transfer, the holder
thereof shall give written notice to the Company of such holder's intention to
effect such transfer. Each such notice shall describe the manner and
circumstances of the proposed transfer in sufficient detail, and shall be
accompanied (except in the following cases, with respect to which the
requirements set forth in the balance of this sentence need not be complied
with: transactions in compliance with Rule 144 so long as the Company is
furnished with evidence of compliance with such Rule, including without
limitation, an opinion of counsel to such effect; transactions involving the pro
rata distribution of Restricted Securities by any holder which is a general or
limited partnership to any of its partners, or retired partners, or to the
estate of any of its partners or retired partners; transactions involving the
transfer of Restricted Securities by any holder who is an individual to his
family members or to a trust for the benefit of such holder or his family
members; or transfers not involving a change in beneficial ownership) by which
the requirements set forth in the balance of this sentence need not be complied
with: transactions in compliance with Rule 144 so long as the Company is
furnished with evidence of compliance with such Rule, including without
limitation, an opinion of counsel to such effect; transactions involving the pro
rata distribution of Restricted Securities by any holder which is a general or
limited partnership to any of its partners, or retired partners, or to the
estate of any of its partners or retired partners; transactions involving the
transfer of Restricted Securities by any holder who is an individual to his
family members or to a trust for the benefit of such holder or his family
members; or transfers not involving a change in beneficial ownership) by
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either (i) an unqualified written opinion of legal counsel who shall be
reasonably satisfactory to the Company addressed to the Company and reasonably
satisfactory in form and substance to the Company's counsel, to the effect that
the proposed transfer of the Restricted Securities may be effected without
registration under the Securities Act, (ii) a "no action" letter from the
Commission to the effect that the distribution of such securities without
registration will not result in a recommendation by the staff of the Commission
that action be taken with respect thereto, or (iii) such other showing that may
be reasonably satisfactory to legal counsel to the Company, whereupon the holder
of such Restricted Securities shall be entitled to transfer such Restricted
Securities in accordance with the terms of the notice delivered by the holder to
the Company. Each certificate evidencing the Restricted Securities transferred
as above provided shall bear the appropriate restrictive legend set forth in
Section 2.2 above, except that such certificate shall not bear such restrictive
legend if in the opinion of counsel for the Company such legend is not required
in order to establish compliance with any provisions of the Securities Act.
2.4 Requested Registration.
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(a) Request for Registration. In case the Company shall receive from
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Initiating Holders after the first anniversary of the Company's initial public
offering, or after January 1, 1994, whichever shall occur first, a written
request that the Company effect any registration (other than a registration on
Form S-3 or any related form of Registration Statement) covering the
registration of at least twenty percent (20%) of their Registrable Securities
(or a lesser percentage if the anticipated aggregate offering price net of
underwriting discounts and commissions, would exceed $2,000,000), the Company
will:
(i) promptly give written notice of the proposed registration to
all other Holders; and
(ii) as soon as practicable, use its diligent best efforts to
effect such registration (including, without limitation, the execution of an
undertaking to file post-effective amendments, appropriate qualification under
applicable blue sky or other state securities laws and appropriate compliance
with applicable regulations issued under the Securities Act) as may be so
requested and as would permit or facilitate the sale and distribution of all or
such portion of such Registrable Securities as are specified in such request,
together with all or such portion of the Registrable Securities of any Holder or
Holders joining in such request as are specified in a written request given
within fifteen (15) days after receipt of such written notice from the Company;
provided that prior to the Company's initial public offering, no Initiating
Holder may make a written request that the Company effect any registration
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unless the aggregate anticipated offering price would exceed, net of
underwriting discounts and commissions, $5,000,000; and provided further that
the Company shall not be obligated to take any action to effect any such
registration, qualification or compliance pursuant to this Section 2.4:
(A) In any particular jurisdiction in which the Company would be
required to execute a general consent to service of process in effecting such
registration, qualification or compliance unless the Company is already subject
to service in such jurisdiction and except as may be required by the Securities
Act; or
(B) During the period starting with the date sixty (60) days
prior to the Company's estimated date of filing of, and ending on a date six (6)
months following the effective date of, a registration statement pertaining to
an underwritten public offering of securities filed for the account of the
Company (other than a registration relating solely to employee benefit plans or
a registration relating solely to a Commission Rule 145 transaction), provided
that the Company is actively employing in good faith all reasonable efforts to
cause such registration statement to become effective and the Company's estimate
of the date of filing such registration statement is made in good faith; or
(C) After the Company has effected one registration pursuant to
this Section 2.4 and such registration has been declared or ordered effective.
Subject to the foregoing clauses (A), (B) and (C) and to Section 2.4(c),
the Company shall file a registration statement covering the Registrable
Securities so requested to be registered as soon as practicable after receipt of
the request of the Initiating Holders.
(b) Underwriting. If the Holders intend to distribute the Registrable
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Securities covered by their request by means of an underwriting, they shall so
advise the Company as a part of their request made pursuant to Section 2.4 and
the Company shall include such information in the written notice referred to in
Section 2.4(a)(i). The right of any Holder to registration pursuant to Section
2.4 shall be conditioned upon such Holder's participation in such underwriting
and the inclusion of such Holder's Registrable Securities in the underwriting to
the extent requested (unless otherwise mutually agreed by a majority in interest
of the Holders and such Holder) to the extent provided herein. The Company
shall (together with all Holders proposing to distribute their securities
through such underwriting) enter into an underwriting agreement in customary
form with the underwriter or underwriters of recognized national standing
selected for such underwriting by the Company with the
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approval of a majority in interest of the participating Holders.
Notwithstanding any other provision of this Section 2.4, if the underwriter
determines that marketing factors require a limitation of the number of shares
to be underwritten or that applicable state law prohibits the registration of
any Holders' Registrable Securities because of the failure or lack of obligation
of such Holder to contribute to the cost of such registration and so advises the
participating Holders in writing, then the Company shall so advise all Holders
(except those Holders who have indicated to the Company their decision not to
distribute any of their Registrable Securities through such underwriting) and
the number of shares of Registrable Securities that may be included in the
registration and underwriting shall be allocated among all such Holders in
proportion, as nearly as practicable, to the respective amounts of Registrable
Securities owned by such Holders at the time of filing the registration
statement. No Registrable Securities excluded from the underwriting by reason of
the underwriter's marketing limitation or such state law shall be included in
such registration.
If any Holder disapproves of the terms of the underwriting, such person may
elect to withdraw therefrom by written notice to the Company, the underwriter
and the other Holders. The Registrable Securities and/or other securities so
withdrawn from such underwriting shall also be withdrawn from such registration;
provided, however, that, if by the withdrawal of such Registrable Securities a
greater number of Registrable Securities held by other Holders may be included
in such registration (up to the maximum of any limitation imposed by the
underwriters), then the Company shall offer to all Holders who have included
Registrable Securities in the registration the right to include additional
Registrable Securities in the same proportion used above in determining the
underwriter limitation.
If the underwriter has not limited the number of Registrable Securities to
be underwritten, the Company may include securities for its own account or the
account of others in such registration if the underwriter so agrees and if the
number of Registrable Securities which would otherwise have been included in
such registration and underwriting will not thereby be limited.
(c) Delay of Registration. If the Company shall furnish to the
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Holders a certificate signed by the President of the Company stating that, in
the good faith judgment of the Board of Directors of the Company, it would be
seriously detrimental to the Company and its shareholders for such registration
statement to be filed on or before the date filing would be required and it is
therefore essential to defer the filing of such registration statement, then the
Company may direct that such request for registration be delayed not in excess
of one hundred
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and fifty (150) days, such right to delay a request to be exercised by the
Company not more than twice in any one-year period.
2.5 Company Registration.
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(a) If at any time or from time to time, the Company shall determine
to register any of its Common Stock, for its own account or for the account of
others (other than the Holders), other than a registration relating solely to
employee benefit plans or a registration relating solely to a Commission Rule
145 transaction or a registration on any registration form which does not
include substantially the same information as would be required to be included
in a registration statement covering the sale of Registrable Securities, the
Company will:
(i) promptly give to each Holder written notice thereof (which
shall include a list of the jurisdictions in which the Company intends to
attempt to qualify such securities under the applicable blue sky or other state
securities laws); and
(ii) include in such registration (and any related qualification
under blue sky laws or other compliance), and in any underwriting involved
therein, all the Registrable Securities specified in a written request or
requests, made within twenty (20) days after receipt of such written notice from
the Company, by any Holder or Holders. The rights of a particular Holder under
this Section 2.5 shall terminate five (5) years after the effective date of the
Company's initial underwritten public offering.
(b) Underwriting. If the registration of which the Company gives
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notice is for a registered public offering involving an underwriting, the
Company shall so advise the Holders as a part of the written notice given
pursuant to Section 2.5(a)(i). In such event the right of any Holder to
registration pursuant to Section 2.5 shall be conditioned upon such Holder's
participation in such underwriting and the inclusion of such Holder's
Registrable Securities in the underwriting to the extent provided herein. All
Holders proposing to distribute their securities through such underwriting shall
(together with the Company and the other holders distributing their securities
through such underwriting) enter into an underwriting agreement in customary
form with the underwriter or underwriters selected for such underwriting by the
Company.
Notwithstanding any other provision of this Section 2.5, if the underwriter
determines that marketing factors require a limitation of the number of shares
to be underwritten, the underwriter may exclude some or all Registrable
Securities from such registration and underwriting. The Company shall so advise
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all Holders (except those Holders who have indicated to the Company their
decision not to distribute any of their Registrable Securities through such
underwriting), and the number of shares of Registrable Securities that may be
included in the registration and underwriting shall be allocated among such
Holders in proportion, as nearly as practicable, to the respective amounts of
Registrable Securities owned by such Holders at the time of filing the
registration statement. No Registrable Securities excluded from the underwriting
by reason of the underwriter's marketing limitation shall be included in such
registration.
If any Holder disapproves of the terms of any such underwriting, such
person may elect to withdraw therefrom by written notice to the Company and the
underwriter. The Registrable Securities and/or other securities so withdrawn
from such underwriting shall also be withdrawn from such registration; provided,
however, that, if by the withdrawal of such Registrable Securities a greater
number of Registrable Securities held by other Holders may be included in such
registration (up to the maximum of any limitation imposed by the underwriters),
then the Company shall offer to all Holders who have included Registrable
Securities in the registration the right to include additional Registrable
Securities in the same proportion used above in determining the underwriter
limitation.
2.6 Registrations on Form S-3.
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(a) If (i) Holders of Registrable Securities request in writing
(specifying that the request is being made pursuant to this Section 2.6) that
the Company file a registration statement on Form S-3 (or any successor form to
Form S-3 regardless of its designation) for a public offering of shares of
Registrable Securities the reasonably anticipated aggregate proceeds of which
would exceed $500,000, and (ii) the Company is a registrant entitled to use Form
S-3 to register such shares, and (iii) the Company has not filed a registration
statement pursuant to this Section 2.6 within the twelve (12) months immediately
prior to the requested filing date, then the Company shall cause such shares,
and any additional shares included pursuant to Section 2.6(b), to be registered
on Form S-3 (or any successor form to Form S-3).
(b) Prior to effecting a registration of Registrable Securities
pursuant to Section 2.6(a), the Company shall (i) give to each Holder written
notice of the intended registration and (ii) include in such registration any
additional Registrable Securities specified in any written request or requests
by additional Holders received within fifteen (15) days after such written
notice is given.
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(c) All expenses incurred in connection with any registrations
requested pursuant to this Section 2.6 including, without limitation, all
registration, qualification, printing, and accounting fees, and fees and
disbursements of counsel for the Company, shall be borne by the Holder or
Holders participating in such registration on the basis of the amount of
securities so registered.
(d) The Holders' rights to registration under this Section 2.6 are in
addition to, and not in lieu of, their rights to registration under Sections 2.4
and 2.5.
2.7 Expenses of Registration.
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(a) All Registration Expenses (exclusive of underwriting discounts and
commissions and more than a single special counsel to the selling shareholders)
incurred in connection with the first registration pursuant to Section 2.4 shall
be borne by the Company. The Company shall not, however, be required to pay for
expenses of any registration proceeding begun pursuant to Section 2.4, the
request of which has been subsequently withdrawn by the Initiating Holders
(unless the withdrawal is based upon material adverse information concerning the
Company of which the Initiating Holders were not aware at the time of such
request and the Holders of a majority of Registrable Securities agree to forfeit
their right to one requested registration pursuant to Section 2.4 in which event
such right shall be forfeited by all Holders), in which case such expenses shall
be borne by the holders of securities (including Registrable Securities)
requesting such registration in proportion to the number of shares for which
registration was requested and such registration shall not be counted as a
registration pursuant to Section 2.4 for purposes of Section 2.4(a)(ii)(B).
(b) All Registration Expenses (exclusive of underwriting discounts and
commissions and more than a single special counsel to the selling shareholders)
incurred in connection with the first two registrations pursuant to Section 2.5
shall be borne by the Company. In each subsequent registration of Registrable
Securities effected pursuant to Section 2.5, the Holders who include Registrable
Securities in such registration shall bear any additional registration and
qualification fees and expenses (including underwriters' discounts and
commissions), and any additional costs and disbursements of counsel for the
Company that result from the inclusion of the Registrable Securities in such
registration, with such additional expenses of the registration being borne by
all such Holders pro rata on the basis of the amount of Registrable Securities
so registered; provided, however, that if any such cost or expense is
attributable solely to one selling Holder and does not constitute a normal cost
or expense of such a
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registration, such cost or expense shall be allocated to that selling Holder. In
addition, each selling Holder shall bear the fees and costs of its own counsel.
2.8 Registration Procedures. In the case of each registration,
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qualification or compliance effected by the Company pursuant to this Section 2,
the Company will keep each Holder advised in writing as to the initiation of
each registration, qualification and compliance and as to the completion
thereof. At its expense the Company will:
(a) Keep such registration, qualification or compliance effective for
a period of one hundred and twenty (120) days or until the Holder or Holders
have completed the distribution described in the registration statement relating
thereto, whichever first occurs; and
(b) Furnish such number of prospectuses and other documents incident
thereto as a Holder from time to time may reasonably request.
2.9 Indemnification.
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(a) The Company will indemnify each Holder, each of its officers,
directors, employees, agents, partners and legal counsel, and each person
controlling such Holder, with respect to which registration, qualification or
compliance has been effected pursuant to this Section 2, and each underwriter,
if any, and each person who controls any underwriter against all claims, losses,
damages and liabilities (or actions in respect thereof) arising out of or based
on (i) any untrue statement (or alleged untrue statement) of a material fact
contained in any prospectus, offering circular or other similar document
(including any related registration statement, notification or the like)
incident to any such registration, qualification or compliance, or based on any
omission (or alleged omission) to skate therein a material fact required to be
stated therein or necessary to make the statements therein not misleading in the
light of the circumstances under which they were made, or (ii) any violation by
the Company of any federal, state or common law rule or regulation applicable to
the Company in connection with any such registration, qualification or
compliance, and will reimburse each such Holder, each of its officers,
directors, employees, agents, partners and legal counsel, and each person
controlling such Holder, each such underwriter and each person who controls any
such underwriter, for any legal and any other expenses reasonably incurred in
connection with investigating or defending any such claim, loss, damage,
liability or action, as incurred, provided that the Company will not be liable
in any such case to the extent that any such claim, loss, damage, liability or
expense arises out of or is based on any untrue statement or omission based upon
written information furnished to the Company
12
<PAGE>
by an instrument duly executed by such Holder or underwriter and specifically
for use therein.
(b) Each Holder will, if Registrable Securities held by such Holder
are included in the securities as to which such registration, qualification or
compliance is being effected, indemnify the Company, each of its directors,
officers, employees and agents each legal counsel and independent accountant of
the Company, each underwriter, if any, of the Company's securities covered by
such a registration statement, each person who controls the Company or such
underwriter within the meaning of the Securities Act, and each other such
Holder, each of its officers, directors, and partners and each person
controlling such Holder, against all claims, losses, damages and liabilities (or
actions in respect thereof) arising out of or based on any untrue statement (or
alleged untrue statement) of a material fact contained in any such registration
statement, prospectus, offering circular or other similar document, or any
omission (or alleged omission) to state therein a material fact required to be
stated therein or necessary to make the statements therein not misleading in the
light of the circumstances under which they were made, and will reimburse the
Company, such Holders, such directors, officers, employees, agents, persons,
underwriters or control persons for any legal or any other expenses reasonably
incurred in connection with investigating or defending any such claim, loss,
damage, liability or action, as incurred, in each case to the extent, but only
to the extent, that such untrue statement (or alleged untrue statement) or
omission (or alleged omission) is made in such registration statement,
prospectus, offering circular or other document in reliance upon and in
conformity with written information furnished to the Company by an instrument
duly executed by such Holder and specifically for use therein; provided,
however, that the obligations of such Holders hereunder shall be limited to an
amount equal to the proceeds to each such Holder of Registrable Securities sold
as contemplated herein.
(c) Each party entitled to indemnification under this Section 2.9 (the
"Indemnified Party") shall give notice to the party required to provide
indemnification (the "Indemnifying Party") promptly after such Indemnified Party
has received written notice of any claim as to which indemnity may be sought,
and shall permit the Indemnifying Party to assume the defense of any such claim
or any litigation resulting therefrom, provided that counsel for the
Indemnifying Party, who shall conduct the defense of such claim or litigation,
shall be approved by the Indemnified Party (whose approval shall not
unreasonably be withheld). The Indemnified Party may participate in such
defense at such party's expense; provided, however, that the Indemnifying Party
shall bear the expense of such defense of the Indemnified Party if
representation of both parties by the same counsel would be inappropriate due to
actual or potential conflicts of
13
<PAGE>
interest. The failure of any Indemnified Party to give notice as provided herein
shall relieve the Indemnifying Party of its obligations under this Section 2
only to the extent that such failure to give notice shall materially adversely
prejudice the Indemnifying Party in the defense of any such claim or any such
litigation. No Indemnifying Party, in the defense of any such claim or
litigation, shall, except with the consent of each Indemnified Party, consent to
entry of any judgment or enter into any settlement which does not include as an
unconditional term thereof the giving by the claimant or plaintiff to such
Indemnified Party of a release from all liability in respect to such claim or
litigation (without any obligation of performance or admission by the
Indemnified Party).
(d) Notwithstanding anything contained in this Section 2.9 to the
contrary, the Company shall have the right and the ability to provide the
necessary undertakings to the Commission in connection with any registration.
2.10 Information by Holder. The Holder or Holders of Registrable
---------------------
Securities included in any registration shall furnish to the Company such
information regarding such Holder or Holders and the distribution proposed by
such Holder or Holders as the Company may request in writing and as shall be
required in connection with any registration, qualification or compliance
referred to in this Section 2.
2.11 Rule 144 Reporting. With a view to making available the benefits of
------------------
certain rules and regulations of the Commission which may at any time permit the
sale of the Restricted Securities to the public without registration, after such
time as a public market exists for the Common Stock of the Company, the Company
agrees to:
(a) Use its best efforts to facilitate the sale of the Restricted
Securities to the public, without registration under the Securities Act,
pursuant to Rule 144 under the Securities Act, provided that this shall not
require the Company to file reports under the Securities Act and the Exchange
Act at any time prior to the Company's being otherwise required to file such
reports.
(b) Use its best efforts to make and keep public information
available, as those terms are understood and defined in Rule 144 under the
Securities Act at all times after ninety (90) days after the effective date of
the first registration under the Securities Act filed by the Company for an
offering of its securities to the general public;
(c) Use its best efforts to then file with the Commission in a timely
manner all reports and other documents required of the Company under the
Securities Act and the Exchange
14
<PAGE>
Act, as amended (at any time after it has become subject to such reporting
requirements);
(d) So long as any Holder holds any Restricted Securities to furnish
to the Holder forthwith upon request a written statement by the Company as to
its compliance with the reporting requirements of said Rule 144 (at any time
after ninety (90) days after the effective date of the first registration
statement filed by the Company for an offering of its securities to the general
public), and of the Securities Act and the Exchange Act (at any time after it
has become subject to such reporting requirements), a copy of the most recent
annual or quarterly report of the Company, and such other reports and documents
so filed by the Company as a Holder may reasonably request in availing itself of
any rule or regulation of the Commission allowing a Holder to sell any such
securities without registration.
2.12 "Market Stand-off" Agreement. Each Holder of more than one percent
---------------------------
(1%) of the Company's outstanding voting stock agrees not to sell or otherwise
transfer or dispose of any Common Stock (or other securities) of the Company
held by it during the one hundred fifty (150) day period following the effective
date of a registration statement of the Company filed under the Securities Act
if so requested by the Company and underwriter of Common Stock (or other
securities) of the Company, provided that:
(a) such agreement shall apply only to the first underwritten
registered public offering of the Company; and
(b) all officers and directors of the Company and all other holders of
at least one percent (1%) of the Company's voting securities enter into similar
agreements. The Company may impose stop-transfer instructions with respect to
the shares (or securities) subject to the foregoing restriction until the end of
such period.
2.13 Transfer of Registration Rights. The rights to cause the Company to
-------------------------------
register securities granted under this Section 2 may be assigned or otherwise
conveyed by (i) any Holder (other than an Option Holder) only to a transferee or
assignee in a private transaction to whom not less than 100,000 shares of
Registrable Securities are conveyed (as presently constituted and subject to
subsequent adjustments for stock splits, stock dividends, reverse stock splits,
and the like) or (ii) an Option Holder in the manner set forth above or
otherwise only to another Holder or to a family member or to a trust for the
benefit of such Option Holder or family members in a private transaction to whom
not less than 20,000 shares of Registrable Securities are conveyed (as presently
constituted and subject to subsequent adjustments as set forth above); provided
that the Company is given written notice by such transferee at the time of or
within
15
<PAGE>
a reasonable time after said transfer, stating the name and address of said
transferee and said transferee's agreement to be bound by the provisions of this
Agreement.
2.14 Suspension of Registration Rights. The registration rights granted
---------------------------------
pursuant to this Section 2 shall not be exercisable by any Holder during the
period in which such Holder has the ability to sell all of the Shares held by
such Holder under Rule 144 or Rule 144A during a single ninety (90) day period.
2.15 Certain Limitations in Connection with Future Grants of Registration
--------------------------------------------------------------------
Rights. From and after the date of this Agreement, the Company shall not enter
------
into any agreement with any holder or prospective holder of any securities of
the Company providing for the granting to such holder of registration rights
unless such agreement:
(a) includes the equivalent of Section 2.12 as a term; and
(b) contains provisions substantially similar to those contained in
Sections 2.4(b) and 2.5(b) with respect to the allocation of Registrable
Securities to be included in an underwritten public offering if marketing
factors require a limitation on the number of such securities to be included.
Notwithstanding the foregoing, from and after the date hereof the Company
shall not enter into any agreement with any person or persons providing for the
granting to such holder registration rights superior to those granted to Holders
pursuant to this Section 2, or of registration rights which might cause a
reduction in the number of shares includable by the Holders in any offering
pursuant to Section 2.4 or in any offering subject to Section 2.5.
SECTION 3
Affirmative Covenants
---------------------
Notwithstanding any provision of the Company's Bylaws regarding
delivery or non-delivery of financial information to shareholders of the
Company, the Company hereby covenants and agrees as follows:
3.1 Financial Information. The Company will furnish the following
---------------------
information to each Holder (other than the Option Holders) for so long as it is
a holder of any Shares or Common Stock issued upon conversion thereof, or of
450,000 shares or more of Common Stock:
16
<PAGE>
(a) As soon as practicable after the end of each fiscal year, and
in any event within one hundred and twenty (120) days thereafter, a consolidated
balance sheet of the Company and its subsidiaries, if any, as of the end of such
fiscal year, and consolidated statements of income, shareholders' equity and
cash flows of the Company and its subsidiaries, if any, for such year, prepared
in accordance with generally accepted accounting principles and setting forth in
each case in comparative form the figures for the previous fiscal year, all in
reasonable detail and with an audit opinion thereon from independent public
accountants of recognized national standing selected by the Company.
(b) As soon as practicable after the end of the first, second and
third quarterly accounting periods in each fiscal year of the Company, and in
any event within forty-five (45) days thereafter, a consolidated balance sheet
of the Company and its subsidiaries, if any, as of the end of each such
quarterly period, and consolidated statements of income, shareholders' equity
and cash flows of the Company and its subsidiaries, if any, for such period and
for the current fiscal year to date, prepared in accordance with generally
accepted accounting principles, with the exception that no notes need be
attached to such statements and year-end audit adjustments may not have been
made. Said financial statements shall be signed by an officer of the Company who
shall state that such financial statements are in accordance with generally
accepted accounting principles, with the exception that no notes need be
attached to such statements and year-end audit adjustments may not have been
made.
3.2 Other Information. The Company shall furnish the following
-----------------
information to each Holder (other than the Option Holders) for so long as it
(together with its affiliates) holds 450,000 or more Shares (on an as-converted-
to-Common-Stock basis) or shares of Common Stock.
(a) As soon as practicable after the end of each fiscal month,
and in any event within thirty (30) days thereafter, a consolidated balance
sheet of the Company and its subsidiaries, if any, as at the end of such month,
and a consolidated statement of income of the Company and its subsidiaries, if
any, for such month, and for the current fiscal year to date, in each case
setting forth in comparative form the Company's and its subsidiaries', if any,
projected consolidated balance sheets and projected consolidated statements of
income for the corresponding periods as set forth in the annual budget (as
prepared pursuant to Section 3.2(b)), prepared in accordance with generally
accepted accounting principles, all in reasonable detail and certified subject
to changes resulting from year-end audit adjustments, by the principal financial
officer of the Company; provided, however, that any financial statements
provided hereunder need not contain any footnotes. To such
17
<PAGE>
financial statements there shall be appended a discussion and analysis, in
reasonable detail, of such financial statements and the general business
condition and prospects of the Company by management of the Company so as to
assist the recipients in understanding and interpreting such financial
statements.
(b) After adoption by the Board of Directors, but not later than
thirty (30) days prior to beginning of each fiscal year, an annual budget for
such year which shall include monthly capital and operating expense budgets,
cash flow statements, projected balance sheets and profit and loss statements
for each month and for the end of such year itemized in such detail as the Board
of Directors may reasonably determine. Approval of such budgets, statements and
projections shall be required by a majority of the Board of Directors.
(c) Within thirty (30) days after a material change has been made
in the annual budget specified in Section 3.2(b) previously delivered, revised
budgets, statements or projections (as so specified).
(d) Copies of all reports, registration statements and other
material filed by the Company or any subsidiary with the Commission or with any
national securities exchange on which securities of the Company or any
subsidiary may be listed.
(e) The covenants provided in this Section 3.2 shall be suspended
for so long as the Company is subject to the reporting requirements of Section
13(a) or 15(d) of the Exchange Act.
3.3 Inspection Rights. Each holder (other than the Option Holders)
-----------------
of any Shares or Common Stock issued upon conversion thereof, or of 450,000 or
more shares of Common Stock shall have the right to visit and inspect any of the
properties of the Company or any of its subsidiaries, and to discuss their
affairs, finances and accounts with their officers, all at such reasonable times
and as often as may be reasonably requested.
3.4 Assignment of Rights to Information. The rights granted pursuant
-----------------------------------
to Sections 3.1, 3.2 and 3.3 may be assigned or otherwise conveyed by any Holder
or by any subsequent transferee of any such rights; provided that the Company is
given notice of the assignment or conveyance; and provided further that if the
Company reasonably believes that it is necessary to protect proprietary
information, the Company may edit such information delivered to a transferee.
3.5 Confidentiality. Each Holder agrees that it will keep
---------------
confidential and will not, except as required by law, including without
limitation freedom of information acts, disclose or divulge any confidential,
proprietary or secret information which
18
<PAGE>
such Holder may obtain from the Company, and which the Company has prominently
marked "confidential", "proprietary" or "secret" or has otherwise identified as
being such, pursuant to financial statements, reports and other materials
submitted by the Company as required hereunder, or pursuant to visitation or
inspection rights granted hereunder unless such information is or becomes known
to the Holder from a source other than the Company (unless such Holder knows
that such information was improperly obtained from the Company) or is or becomes
publicly known, or unless the Company gives its written consent to the Holder's
release of such information, except that no such written consent shall be
required (and Holder shall be free to release such information) if such
information is to be provided to Holder's lawyer or accountant, or to an
officer, director or partner of a Holder.
3.6 Employee Agreements. Those current and future employees and
-------------------
officers of and consultants to the Company designated by the Board of Directors
shall be required to execute a proprietary information agreement substantially
in the form attached hereto as Exhibit B with such amendments thereto as the
Board of Directors may from time to time deem appropriate.
3.7 Insurance. As soon as possible after the date hereof the Company
---------
shall obtain and keep adequate insurance on its properties, by financially sound
and reputable insurers, of a character and in such amounts and on such terms
usually insured by corporations engaged in the same or a similar business
against loss or damage resulting from fire or other risks insured against by
extended coverage and of the kind customarily insured against by such
corporations, and maintain in full force and effect public liability insurance
against claims for personal injury, death or property damage occurring upon, in,
about or in connection with the use of any of its properties, and maintain such
other insurance as may be required by law or other agreements to which the
Company is or shall become a party.
3.8 Board of Directors. The Company shall reimburse directors of the
------------------
Company for their reasonable expenses (including travel, meals and lodging)
incurred in the service of the Company, including the attendance at Board of
Directors meetings, pursuant to policies established by the Board of Directors.
SECTION 4
Right of First Refusal
----------------------
4.1 Right of First Refusal. The Company hereby grants to each Holder
----------------------
the right of first refusal to purchase, pro rata, New Securities that the
Company may, from time to time, propose to sell and issue. Each Holder's pro
rata share, for purposes of this right of first refusal, is the ratio of the
number of
19
<PAGE>
shares of Common Stock (and shares of Common Stock issuable upon conversion of
securities convertible into shares of Common Stock), excluding the number of
shares of Common Stock which may be issued upon exercise of any Option, actually
held by such Holder, to the total number of outstanding shares of Common Stock
(calculated on a fully diluted basis) of the Company. This right of first
refusal shall be subject to the following provisions:
(a) In the event that the Company proposes to undertake an issuance of
New Securities, it shall give each Holder written notice of its intention,
describing the type of New Securities, the price, and the general terms upon
which the Company proposes to issue the same. Each Holder shall have ten (10)
business days from the date of receipt of any such notice to agree to purchase
its pro rata share of such New Securities for the price and upon the general
terms specified in the notice by giving written notice to the Company and
stating therein the quantity of New Securities to be purchased. Each Holder
shall have a right of over allotment such that if any Holder fails to exercise
its right hereunder to purchase its pro rata portion of New Securities, the
Company shall so notify the other Holders and the other Holders may purchase the
non-purchasing Holder's portion on a pro rata basis, within ten (10) days from
the date of such notice.
(b) In the event that a Holder fails to exercise in full the right of
first refusal within said ten (10) day period (plus ten (10) day period, if
applicable) the Company shall have ninety (90) days thereafter to sell the New
Securities respecting which the Holders' rights were not exercised, at a price
and upon general terms no more favorable to the purchasers thereof than
specified in the Company's notice. In the event the Company has not sold the
New Securities within such ninety (90) day period, the Company shall not
thereafter issue or sell any New Securities, without first offering such
securities to the Holders in the manner provided above.
(c) The right of first refusal granted under this Agreement shall
expire upon the closing of the first firmly underwritten public offering of
Common Stock of the Company pursuant to a registration statement filed with, and
declared effective by, the Commission under the Securities Act, covering the
offer and sale of Common Stock to the public at a per-share price (prior to
underwriters' commissions and expenses) of at least $5.00 (as adjusted for any
combinations, consolidations, stock distributions or stock dividends with the
respect to such stock) and at an aggregate offering price of not less than
$10,000,000.
(d) This right of first refusal is assignable only in connection with
a sale of Shares or Common Stock issued on conversion thereof.
20
<PAGE>
4.2 Waiver. The Series A Investors, the Founders and the University
------
each hereby waive their respective rights under Section 4.1 of the Investors'
Rights Agreement to purchase their pro rata share of the Series B Preferred
Stock being issued to the Series B Investors pursuant to that certain Series B
Preferred Stock Purchase Agreement of even date herewith (the "Series B
Agreement").
SECTION 5
University Warrants
-------------------
5.1 Termination of Warrant Rights. The right of the University to
-----------------------------
obtain warrants to purchase Common Stock of the Company, contained in Section
5.1 of the Investors' Rights Agreement, is hereby terminated.
SECTION 6
Miscellaneous
-------------
6.1 Amendment of Investors' Rights Agreement. Effective and
----------------------------------------
contingent upon the closing of the sale of the Series B Preferred Stock pursuant
to the Series B Agreement, all of the provisions of the Investors' Rights
Agreement shall be null and void and superseded by this Agreement. The parties
to such Investors' Rights Agreement forever release, waive and disclaim any and
all rights under such Agreement. The parties hereto further agree that this
Agreement constitutes the full and entire understanding and agreement between
the parties with regard to the subjects hereof and thereof, except that no
provision, condition or term of this Agreement, including but not limited to
Section 6.8 below, is intended to explicitly or implicitly alter or allow to be
altered any provision, condition or term of the UM-Ann Arbor Stromal Agreement.
6.2 Governing Law. This agreement shall be governed by and construed
-------------
in accordance with the laws of the State of Michigan applicable to contracts
between Michigan residents entered into and to be performed entirely within the
State of Michigan.
6.3 Successors and Assigns. Except as otherwise provided herein, the
----------------------
provisions hereof shall inure to the benefit of, and be binding upon, the
successors, assigns, heirs, executors and administrators of the parties hereto.
6.4 Notices. All notices and other communications required or
-------
permitted hereunder shall be in writing and shall be effective five (5) days
after mailed by first-class mail, postage prepaid,
21
<PAGE>
or otherwise delivered by hand or by messenger, addressed (a) if to an Investor
at such Investor's address set forth on Exhibit A, or at such other address as
such Investor shall have furnished to the Company in writing, or (b) if to any
other Holder, at such address as such Holder shall have furnished the Company in
writing, or, until any such Holder so furnishes an address to the Company, then
to and at the address of the last holder of such Registerable Securities who has
so furnished an address to the Company, or (c) if to the Company, at such
address as the Company shall have furnished to each Holder in writing.
6.5 Delays or Omissions. No delay or omission to exercise any right,
-------------------
power or remedy accruing to any holder of any Registerable Securities, upon any
breach or default of the Company under this Agreement, shall impair any such
right, power or remedy of such Holder nor shall it be construed to be a waiver
of any such breach or default, or an acquiescence therein, or of or in any
similar breach or default thereunder occurring; nor shall any waiver of any
single breach or default be deemed a waiver of any other breach or default
theretofore or thereafter occurring. Any waiver, permit, consent or approval of
any kind or character on the part of any holder of any breach or default under
this Agreement, or any waiver on the part of any holder of any provisions or
conditions of this Agreement, must be in writing and shall be effective only to
the extent specifically set forth in such writing. All remedies, either under
this agreement, or by law or otherwise afforded to any Holder, shall be
cumulative and not alternative.
6.6 Counterparts. This Agreement may be executed in any number of
------------
counterparts, each of which may be executed by less than all of the Holders,
each of which shall be enforceable against the parties actually executing such
counterparts, and all of which together shall constitute one instrument.
6.7 Severability. In the case any provision of this Agreement shall
------------
be invalid, illegal or unenforceable, the validity, legality and enforceability
of the remaining provisions shall not in any way be affected or impaired
thereby.
6.8 Amendments. The provisions of this Agreement may be amended at
----------
any time and from time to time, and particular provisions of this Agreement may
be waived, with and only with an agreement or consent in writing signed by the
Company and by the Holders of a majority of the number of shares of Registrable
Securities (or securities convertible into Registrable Securities) outstanding
as of the date of such amendment or waiver. Each party to this Agreement
acknowledges that by the operation of this Section the holders of a majority of
the outstanding Registrable Securities may have the right and power to diminish
or eliminate all rights of such holder under this Agreement.
22
<PAGE>
IN WITNESS WHEREOF, the parties have caused this Agreement to be duly
executed and delivered as of the date first above written.
COMPANY:
AASTROM BIOSCIENCES, INC.
By /s/ R. DOUGLAS ARMSTRONG
-----------------------------------
Dr. R. Douglas Armstrong
President
INVESTORS:
H&Q LIFE SCIENCE TECHNOLOGY FUND I
By /s/ JACKIE BERTERRETCHE
--------------------------------
Title Attorney-In-Fact
--------------------------------
H&Q LONDON VENTURES
By /s/ JACKIE BERTERRETCHE
---------------------------------
Title Attorney-In-Fact
---------------------------------
STATE TREASURER OF THE STATE OF MICHIGAN
CUSTODIAN OF PUBLIC SCHOOL EMPLOYEES'
RETIREMENT SYSTEM; STATE EMPLOYEES'
RETIREMENT SYSTEM; MICHIGAN STATE POLICE
RETIREMENT SYSTEM; JUDGES' RETIREMENT
SYSTEM; AND PROBATE JUDGES' RETIREMENT
SYSTEM
By /s/ PAUL E. RICE
---------------------------------
Title Paul E. Rice, Administrator
---------------------------------
Venture Capital and LBO Division
23
<PAGE>
BRENTWOOD ASSOCIATES V, L.P.
By: Brentwood V Ventures, L.P.
Its General Partner
By /s/ G. BRADFORD JONES
------------------------------------
WIND POINT PARTNERS II, L.P.
By /s/ ROBERT CUMMINGS
------------------------------------
Title General Partner
---------------------------------
GC&H PARTNERS
By /s/ EDWIN E. HUDDLESON, JR.
------------------------------------
Title General Partner
---------------------------------
/s/ MICHAEL B. STAEBLER
---------------------------------------
Michael B. Staebler, Esq.
OPTION HOLDERS:
/s/ STEPHEN G. EMERSON
---------------------------------------
Stephen G. Emerson
/s/ BERNHARD O. PALSSON
---------------------------------------
Bernhard O. Palsson
/s/ MICHAEL F. CLARKE
---------------------------------------
Michael F. Clarke
/s/ R. DOUGLAS ARMSTRONG
---------------------------------------
R. Douglas Armstrong
26
<PAGE>
THE REGENTS OF THE UNIVERSITY OF MICHIGAN:
By /s/ NORMAN G. HERBERT
---------------------------------------
Norman G. Herbert
Title Investment Officer/Treasurer
------------------------------------
By /s/ C.W. MATTHEWS
---------------------------------------
C.W. Matthews
Title Associate Vice President for
------------------------------------
Finance and Controller
------------------------------------
34
<PAGE>
EXHIBIT A
---------
Series A Investors Shares
------------------ ---------
H&Q Life Science Technology Fund I 875,000
One Bush Street, 18th Floor
San Francisco, CA 94104
H&Q London Ventures 875,000
One Bush Street, 18th Floor
San Francisco, CA 94104
State Treasurer of the State of 750,000
Michigan, Custodian of Certain
Retirement Systems
c/o Venture Capital Division
430 West Allegan, First Floor
Treasury Building
Lansing, MI 48933
---------
TOTAL 2,500,000
Series B Investors Shares
------------------- ---------
Brentwood Associates, V., L.P. 850,000
11150 Santa Monica, Blvd.
Suite 1200
Los Angeles, CA 90025
Attn: Brad Jones
Wind Point II, L.P. 750,000
321 North Clark Street
Chicago, IL 60610
Attn: Robert Cummings
H&Q Life Science Technology Fund I 540,000
One Bush Street, 18th Floor
San Francisco, CA 94104
Attn: Robert Kunze
H&Q London Ventures 360,000
One Bush Street, 18th Floor
San Francisco, CA 94104
Attn: Robert Kunze
i.
<PAGE>
State Treasurer of the State 500,000
of Michigan, Custodian of
Certain Retirement Systems
c/o Venture Capital Division
430 West Allegan
Lansing, Michigan 48992
Attn: Joseph Taylor
GC&H Partners 25,000
c/o Cooley Godward Castro
Huddleson & Tatum
One Maritime Plaza
20th Floor
San Francisco, CA 94111
Attn: Jeanne Meyer
Michael B. Staebler, Esq. 5,000
c/o Pepper, Hamilton & Scheetz
100 Renaissance Center
Suite 3600
Detroit, Michigan 48243
---------
TOTALS 3,030,000
ii.
<PAGE>
EXHIBIT "A"
-----------
AASTROM BIOSCIENCES, INC.
P.O. Box 130469
Ann Arbor, Michigan 48113-0469
Gentlemen:
1. The following is a complete list of all inventions or improvements
relevant to the subject matter of my service as a director of AASTROM
BIOSCIENCES, INC. (the "Company") that have been made or conceived or first
reduced to practice by me alone or jointly with others prior to my becoming a
director of the Company:
_____ No inventions or improvements.
_____ See below:
_________________________________________________________________________
_________________________________________________________________________
_________________________________________________________________________
_________________________________________________________________________
_____ Due to confidentiality agreements with prior employer, I cannot
disclose certain inventions that would otherwise be included on the
above-described list.
_____ Additional sheets attached.
2. I propose to bring to my service as a director the following
devices, materials and documents of a former employer or other person to whom I
have an obligation of confidentiality that are not generally available to the
public, which materials and
A-1
<PAGE>
documents may be used in my service as a director pursuant to the express
written authorization of my former employer or such other person (a copy of
which is attached hereto):
_____ No materials.
_____ See below.
________________________________________________________________________
________________________________________________________________________
________________________________________________________________________
________________________________________________________________________
_____ Additional sheets attached.
Dated: ____________________, 19____.
Very truly yours,
________________________________________
A-2
<PAGE>
EXHIBIT B
AASTROM BIOSCIENCES, INC.
DIRECTOR PROPRIETARY INFORMATION AND INVENTION AGREEMENT
--------------------------------------------------------
In consideration of my service as a director or continued service as a
director of AASTROM Biosciences, Inc. ("the Company"), I hereby agree as
follows:
1. Recognition of Company's Rights; Nondisclosure. At all times during
----------------------------------------------
the term of my service as a director and thereafter, I will hold in strictest
confidence and will not disclose or use any of the Company's Proprietary
Information (defined below), except as such disclosure or use may be required in
connection with my work for the Company, or unless an officer of the Company
expressly authorizes such disclosure or use. I assign to the Company any rights
I may have or acquire in such Proprietary information and recognize that all
Proprietary information shall be the sole property for the Company and its
successors and assigns, and the Company and its successors and assigns shall be
the sole owner of all patents, copyrights, and other rights in connection
therewith.
The term "Proprietary Information" shall mean all of the confidential or
proprietary information of the Company, including, but not limited to:
a. inventions, trade secrets, ideas, processes, formulas, source
codes, data, programs, other original works or authorship, know-how,
improvements, discoveries, developments, designs and techniques, (hereinafter
collectively referred to as "Inventions"); and
b. plans for research, development, new products, marketing and
selling; financial statements; licenses; prices and costs; information
concerning suppliers and customers; and information regarding the skills and
compensations of employees of the Company.
Notwithstanding the foregoing, Proprietary information shall not include:
---------
a. information which at the time of disclosure to the undersigned
is in the public domain,
b. information which was received by the undersigned from a third
party having the legal right to transmit the same to the undersigned, or
c. information which was independently developed by the
undersigned without reliance on any information received from the Company.
<PAGE>
I understand, in addition, that the Company has received and in the future
will receive from third parties confidential or proprietary information ("Third
Party Information") subject to a duty on the Company's part to maintain the
confidentiality of such information and to use it only for certain limited
purposes. During the term of my service as director and thereafter, I will hold
Third Party Information in the strictest confidence and will not disclose or use
Third Party Information except as permitted by the agreement between the Company
and such third party, unless expressly authorized to act otherwise by an officer
of the Company.
2. Assignment of Proprietary Rights. I hereby assign to the Company and
--------------------------------
its successors and assigns all my right, title and interest in and to any and
all inventions whether or not patentable or registrable under copyright or
similar statutes, made or conceived or reduced to practice or learned by me,
either alone or jointly with others, during the term of my service as a director
with the Company. I agree that all such inventions are the sole property of the
Company and its successors and assigns.
I also assign to or as directed by the Company all my right, title and
interest in and to any and all inventions, full title to which is required to be
in the United States by a contract between the Company and the United States or
any of its agencies. Inventions assigned to or as directed by the Company by
this paragraph 2 are hereinafter referred to as "Company Inventions."
Provided however, the foregoing assignment of inventions applies only to
inventions related to the technology and business of the Company, but not to any
---
other inventions which I may make independent from my service with the Company,
or that I may make as part of a formalized collaboration with the Company that
is outside of my role as a director (any such collaboration being established
and mutually agreed to in writing).
3. Enforcement of Proprietary Rights. I will assist the Company in
---------------------------------
every proper way to obtain and from time to time enforce United States and
foreign patents, copyright and other rights and protections relating to Company
inventions in any and all countries. To that end I will execute, verify and
deliver such documents and perform such other acts (including appearances as a
witness) as the Company may reasonably request for use in applying for,
obtaining, sustaining and enforcing such patents, copyrights and other rights
and protections on Company inventions. In addition, I will execute, verify and
deliver assignments of such patents, copyrights, and other rights and
protections to the Company or its designee. My obligation to assist the Company
in obtaining and enforcing patents, copyrights, and other rights and protections
relating to such Company Inventions in any and all countries shall continue
beyond the termination of my service as a director, but the Company shall
compensate me at a reasonable
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<PAGE>
rate after my termination for the time actually spent by me at the Company's
request on such assistance.
In the event the Company is unable, after reasonable effort, to secure my
signature on any document needed to apply for or prosecute any patent,
copyright, or other right or protection relating to a Company Invention, I
hereby irrevocably designate and appoint the Company and its duly authorized
officers and agents as my agent and attorney in fact, to act for an in my behalf
to execute, verify and file any such applications and to do all other lawfully
permitted acts to further the prosecution and issuance of patents, copyrights,
and other rights and protections thereon with the same legal force and effect as
if executed by me.
4. Obligation to Keep Company Informed. During the term of my service
-----------------------------------
as a director, I will disclose to the Company promptly, fully and in writing any
and all inventions. in addition, after termination of my service as a director,
I will disclose all patent applications filed by me within a year after
termination of my service as a director. I agree that any patent application
filed within a year after termination of my service as a director shall be
presumed to relate to an invention made during the term of my service as a
director unless I can sustain the burden of proving the contrary.
5. Prior Inventions. Inventions if any, patented or unpatented, which I
----------------
made prior to the commencement of my service as a director with the Company, are
excluded from the scope of this Agreement. To preclude any possible uncertainty,
I have set forth on Exhibit A attached hereto, a complete list of all inventions
that I have, alone or jointly with other, conceived, developed or reduced to
practice or caused to be conceived, developed, or reduced to practice, prior to
the commencement of my service as a director with the Company, that I consider
to not be Company property and that I wish to have excluded from the scope of
this Agreement.
6. No Improper Use of Materials. During my service as a director at the
----------------------------
Company, I will not improperly use or disclose any confidential information or
trade secrets, if any, of any former or current employer, and I will not bring
onto the premises of the Company any unpublished documents or any property
belonging to any former or current employer unless consented to in writing by
that employer.
7. No Conflicting Obligation. I represent that my performance of all
-------------------------
terms of this Agreement and as a director of the Company does not and will not
breach any agreement to keep in confidence information acquired by me in
confidence or in trust prior to my service as a director by the Company. I have
not
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<PAGE>
entered into, and I agree I will not enter into, any agreement either written or
oral in conflict herewith.
8. Effect of Termination. Upon the termination of my service as a
---------------------
director with the Company, I understand that the Company and I shall be released
from all obligations and liabilities to the other occurring or arising after the
date of such termination, except that any termination of my service as a
director with the Company shall not relieve me of my obligations under Sections
1, 2, 3, 4, and 6 hereof, nor shall any such termination relieve me or the
Company from any liability arising from any breach of the provisions contained
herein. When I discontinue my service as a director of the Company, I will
deliver to the Company any and all drawings, notes, memoranda, specifications,
devices, documents, together with all copies thereof, and any other material
containing or disclosing any Company Inventions, Third Party Information or
Proprietary Information of the Company.
9. Legal and Equitable Remedies. Because my services are personal and
----------------------------
unique and because I may have access to and become acquainted with the
Proprietary Information of the Company, the Company shall have the right to
enforce this Agreement and any of its provisions by injunction, specific
performance or other equitable relief without prejudice to any other rights and
remedies that the Company may have for a breach of this Agreement.
10. Notices. Any notices required or permitted hereunder shall be given
-------
to the appropriate party at the address specified below or at such other address
as the party shall specify in writing.
Such notice shall be deemed given upon personal delivery to the appropriate
address or sent by certified or registered mail, three days after the date of
mailing.
11. Miscellaneous. I agree that, with respect to the subject matter
-------------
hereof, this Agreement constitutes my entire agreement with the Company,
superseding any previous oral or written communications, representations,
understandings, or agreements with the Company or any officer or representative
thereof. This Agreement shall inure to the benefit of the successors and assigns
of the company, and shall be binding upon my successors and assigns. To the
extent that any of the agreements set forth herein, or any word, phrase, clause,
or sentence hereof shall be found to be illegal or unenforceable for any reason,
such agreement, word, phrase, clause, or sentence shall be modified or deleted
in such a manner so as to make the Agreement, as modified, legal and enforceable
under applicable laws. This Agreement shall be governed by the laws of the State
of Michigan, as those laws are applied by Michigan courts to
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<PAGE>
contracts between Michigan residents made and to be performed within the state
of Michigan, which state shall have jurisdiction of the subject matter hereof.
This Agreement may not be changed, modified, released, discharged, abandoned, or
otherwise amended, in whole or in part, except by an instrument in writing
signed by the company and me.
This Agreement shall be effective as of the first day of my service as a
director with the company, namely: _____________________, 19_____.
Date: ___________________ ___________________________________________________
___________________________________________________
Address
___________________________________________________
___________________________________________________
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