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Consulting Agreement - Pharmacopeia Inc. and Richard Walsh

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                              CONSULTING AGREEMENT

This CONSULTING AGREEMENT, made the 12th day of December 2000 is between
PHARMACOPEIA INC. ("PCOP"), a Delaware corporation having a place of business at
3000 Eastpark Blvd., Cranbury, NJ 08512 and RICHARD WALSH ("Consultant"),
located at 49 Benedict Crescent, Denville, New Jersey 07834.

In order to have available Consultant's knowledge, experience, and advice
relative to certain research, product development and/or marketing activities of
PCOP, and in exchange for good and valuable consideration, PCOP and Consultant
hereby agree as follows:

1.   SERVICES: Consultant agrees to perform such consulting, advisory, and
     related services to and for PCOP as may reasonably be requested from time
     to time by PCOP, including, but not limited to, the services specified in
     Attachment A to this Agreement.

2.   TERM: This Agreement is effective as of January 1, 2001 and will continue
     until June 30, 2001 unless otherwise extended (such period is referred to
     as the "Consultation Period"), or until either Consultant or PCOP notifies
     the other in writing of his or its desire to terminate the Consultation
     Period in accordance with the provisions of Section 10.

3.   SERVICE MINIMUMS: During the consultation period of this Agreement and
     subject to the termination provisions of Section 10, PCOP will provide the
     Consultant with the opportunity to perform an average of no less than eight
     (8) full days of consulting services each month for the first three months
     and an average of no less than six (6) full days of consulting services
     during the second three months. Consultant will provide reasonable
     additional amounts of Consulting services as agreed to by Consultant and
     PCOP, subject to the provisions of Section 9.

4.   LOCATION: Consultant's services under this Agreement shall be rendered at
     such times and at such places as will be mutually satisfactory to
     Consultant and PCOP.

5.   INDEPENDENT CONTRACTOR STATUS: Consultant shall perform all services under
     this Agreement as an "Independent Contractor" and not as an employee or
     agent of PCOP. Consultant is not authorized to assume or create any
     obligation or responsibility, express or implied, on behalf of, or in the
     name of, PCOP or to bind PCOP in any manner.

6.   INVENTIONS: Consultant agrees that all inventions, designs, specifications,
     drawings, copyrightable materials, computer programs or code, derivative
     works, processes, techniques, or know-how, (collectively referred to as
     "Inventions"), whether or not patentable, which are conceived, made or
     first reduced to practice by Consultant, individually or jointly with
     others, at any time during the term of this Agreement (or thereafter if
     resulting or directly derived from Proprietary Information as defined
     below) in conjunction with Consultant's work for PCOP, shall be the sole
     property of PCOP, and Consultant hereby transfers to PCOP all right, title
     and interest in and to such Inventions. At PCOP's request, Consultant shall
     execute such instruments and take such further actions as may be
     appropriate to give full legal effect to this Section 6.



     (a)  Consultant acknowledges that his relationship with PCOP is one of high
          trust and confidence and that in the course of his service to PCOP he
          will have access and contact with proprietary, trade secret
          information of PCOP ("Proprietary Information"). Such Proprietary
          Information relates to PCOP's present and planned business, products,
          services and technological information. Consultant agrees and affirms
          his obligation that during the term of this Agreement and for a period
          of five (5) years thereafter he will not use, except for the benefit
          of PCOP, publish, or otherwise disclose in any way to any person, firm
          or corporation any Proprietary Information of PCOP.

     (b)  The above restriction will not apply to any information that (i) is
          rightfully known to or in the rightful possession of Consultant as of
          the date of its disclosure by PCOP, (ii) is generally distributed or
          made available to others by PCOP (without obligation of
          confidentiality) following the date of its disclosure to Consultant,
          or (iii) lawfully becomes known or available to the Consultant from
          third parties who are not under an obligation of confidentiality,
          directly or indirectly, with PCOP.

     (c)  Consultant further agrees that upon request by PCOP he will: (i)
          promptly return to PCOP the originals and all copies of tangible
          Proprietary Information furnished to or otherwise obtained by him; and
          (ii) destroy all notes and copies thereof made by him that contain
          partial or complete copies of the Proprietary Information or material
          derived from the Proprietary Information; and (iii) cause all of
          Consultant's agents and/or representatives to whom the Proprietary
          Information has been disclosed to comply with clauses (i) and (ii) of
          this Section 6(c).

8.   INDEMNIFICATION: Consultant represents that the performance of his services
     under the terms of this Agreement will not breach any agreement by which
     Consultant is bound, including without limitation the obligation to
     maintain as confidential any information acquired by Consultant prior to
     Consultant's term of consultancy with PCOP. Consultant further agrees to
     indemnify PCOP from any and all loss or liability incurred by reason of the
     alleged breach by Consultant of any such prior agreements.


     (a)  In consideration of the foregoing, PCOP hereby agrees to pay
          Consultant at the rate of $2,000.00 for each full day worked as
          defined by an average 8-hour period and a rate of $250 per hour
          worked. Partial workdays will be paid at the rate of $250 per hour if
          such workday is less than six (6) hours. Workdays in excess of eleven
          (11) hours will be paid at the full workday rate plus $250 per hour in
          excess of eleven (11) hours. The total fees due Consultant under this
          Agreement shall not exceed $75,000.00 over any given 3-month period,
          unless otherwise agreed to in writing by both parties.


     (b)  PCOP shall reimburse Consultant for reasonable and necessary expenses
          incurred or paid by Consultant in connection with or related to the
          performance of the services under this Agreement. Consultant shall not
          incur expenses in excess of $1,000 in any one month without the
          express prior written approval of PCOP.

     (c)  Consultant shall invoice PCOP once after the end of each calendar
          month for all services performed under this Agreement. Invoices shall
          be due and payable upon receipt by PCOP.

     (d)  Consultant shall not be entitled to any benefits, coverage, or
          privileges, including, without limitation, social security,
          unemployment, medical or pension payments, made to employees of PCOP.

10.  TERMINATION: Either party may terminate the Consultation Period upon 30
     days written notice to the other party. In the event of such termination,
     Consultant shall be entitled to payment for services performed, taking into
     account the service minimum of Paragraph 3, and expenses paid or incurred
     prior to the effective date of termination. The provisions of Sections 6,
     7, 8, 10 and 13 shall survive any termination of the Consultation Period or
     termination of this Agreement.

11.  INCORPORATION: PCOP acknowledges that Consultant intends to form a
     Corporation ("Walsh Corp.") in January 2001 and that all rights and
     obligation of Consultant under this Agreement will be transferred to Walsh
     Corp. with all services hereunder to be performed by Consultant.

12.  ENTIRE AGREEMENT: This Agreement and Attachment A contain the entire
     agreement between Consultant and PCOP relating to Consultant's services to
     PCOP. No amendment or modification of this Agreement shall be deemed
     effective unless and until executed in writing by the parties hereto. This
     Agreement contemplates unique personal services and shall not be assignable
     by Consultant, except as provided in Section 11.

13.  GOVERNING LAW: This Agreement shall be construed, interpreted and enforced
     in accordance with the laws of the state of New Jersey. If any provision of
     this Agreement shall, to any extent be found to be invalid or
     unenforceable, the remainder of this Agreement shall not be affected
     thereby, and any such invalid or unenforceable provision shall be reformed
     so as to be valid and enforceable to the full extent permitted by law.

EXECUTED AND AGREED by the parties hereto as of the date first above written.

CONSULTANT                                          PHARMACOPEIA, INC.

By:  /S/  RICHARD J. WALSH                          By:  /S/ STEPHEN A. SPEARMAN
   ---------------------------------                   -------------------------

Name:  Richard J. Walsh                             Name:  STEPHEN A. SPEARMAN

Title:  President                                   Title:  EXEC. VICE PRESIDENT

Date:  DECEMBER 13, 2000                            Date:  DECEMBER 13, 2000
     -------------------------------                     -------------------



                                  ATTACHMENT A

                               CONSULTING SERVICES

Consultant shall provide services, including but not limited to those outlined

-    Provide general management consulting for the Drug Discovery Services

-    Provide analysis of market for drug discovery products

-    Determine relative strengths and weaknesses of current business

-    Provide analysis on current and future customer prospects

-    Participate in the identification of potential customers, negotiations of
     contracts and closing of agreements; specific concentration on agreements
     with AHP, Aventis, and Schering-Plough

-    Provide appropriate support and introductions for business opportunities in