Lock-Up Agreement - Biopure Corp. and Thomas A. Moore
August 4, 2003 Biopure Corporation 11 Hurley Street Cambridge, MA 02141 Re: Lock-up of Securities Gentlemen: I am a director of Biopure Corporation ("Biopure"). I hold 189,112 shares of Class A Common Stock of Biopure ("Common Stock") together with associated Common Stock warrants to purchase 37,822 additional shares (collectively, the "Securities") which were issued in an offering on March 25, 2003 (the "Offering"). You intend to seek stockholder approval for sales to insiders in the Offering at the 2004 annual meeting of stockholders. At your request, in the interim, I agree that the Securities shall not be sold, transferred, assigned, pledged or hypothecated, nor will I vote any of the Common Stock included in the Securities. In addition, if the Company pays a dividend on its Common Stock, dividends on the Securities will be withheld. Very truly yours, Thomas A. Moore