Patent Security Agreement - Biopure Corp. and Pharmacia & Upjohn Inc.
PATENT SECURITY AGREEMENT
This PATENT SECURITY AGREEMENT ("Agreement") is made this 8th day of
October, 1996, by and between Biopure Corporation, a Delaware corporation,
having its principal office at 11 Hurley Street, Cambridge, Massachusetts 02141
("Grantor"), and Pharmacia & Upjohn, Inc., a Delaware corporation, having its
principal office at 7000 Portage Road, Kalamazoo, Michigan 49001 ("Grantee").
WHEREAS, Grantor is the owner of the U.S. patents and patent
applications listed on the attached Schedule A (collectively the "Patents");
WHEREAS, Grantee has extended a loan to Grantor pursuant to the
terms and conditions of that certain Promissory Note dated the date hereof
("Note") made by Grantor in favor of Grantee;
WHEREAS, under a Security Agreement dated the date hereof ("Security
Agreement") between Grantor and Grantee, Grantor has granted to Grantee a
security interest in certain of its assets (including the Patents) to secure the
performance of the obligations of Grantor under the Note; and
WHEREAS, Grantor and Grantee by this instrument seek to confirm and
make a record of the grant of a security interest in the Patents.
NOW, THEREFORE, for good and valuable consideration, the receipt and
adequacy of which are hereby acknowledged, Grantor does hereby acknowledge that
it has granted to Grantee a security interest in all of Grantor's right, title
and interest in, to, and under the Patents. Grantor also acknowledges and
confirms that the rights and remedies of Grantee with respect to the security
interests in the Patents granted hereby are more fully set forth in the Note and
the Security Agreement, the terms and provisions of which are incorporated
herein by reference.
BIOPURE CORPORATION PHARMACIA & UPJOHN, INC.
By: /s/ Brian A. Lajoie By: /s/ Robert G. Kramer
---------------------- ---------------------
Name: Brian A. Lajoie Name:
Title: V.P. - Finance Title:
STATE OF Massachussets )
) SS:
COUNTY OF Middlesex )
Subscribed and sworn to this 7th day of October, 1996.
/s/ Hazel V. Forney
------------------------
Notary Public
My Commission Expires: Jan 4, 2002
<PAGE> 3
SCHEDULE A
U.S. Patents and U.S. Patent Applications
<TABLE>
<CAPTION>
Patent No. Title Issue Date
---------- ----- ----------
<S> <C> <C>
5,084,558 Extra Pure Semi-Synthetic 01/28/92
Blood Substitute
5,296,465 Extra Pure Semi-Synthetic 03/22/94
Blood Substitute
5,095,765 Sample Valve for Sterile 03/17/92
Processing
5,295,944 Improved Method for Treating a 03/22/94
Tumor with Ionizing Radiation
<CAPTION>
Patent Application No. Title Filing Date
---------------------- ----- -----------
<S> <C> <C>
08/209,949 Ultra Pure Hemoglobin 03/11/94
Solutions and Blood
Substitutes
08/333,623 Enzymatic Production of 11/02/94
7-Amino Cephalosporanic Acid
08/477,916 Method for Separating 06/07/95
Unmodified Hemoglobin from
Cross-Linked Hemoglobin
08/360,143 Chlorination of Cephalexin 12/20/94
with Chioroperoxidase from
Rathayibacter
08/409,337 Method for Oxygenating Tissue 03/23/95
Having Reduced Red Blood Cell
Flow
08/458,916 Method for Producing Ultrapure 06/02/95
Stable Polymerized Hemoglobin
Blood-Substitute
08/484,775 Method for Producing a Stable 06/07/95
Polymerized Hemoglobin Blood-
Substitute
</TABLE>
-2-
<PAGE> 4
<TABLE>
<CAPTION>
Patent Application No. Title Filing Date
---------------------- ----- -----------
<S> <C> <C>
08/478,004 Method for Producing a Stable 06/07/95
Polymerized Hemoglobin Blood-
Substitute
08/487,288 Stable Polymerized Hemoglobin 06/07/95
and Use Thereof
08/620,296 Stable Polymerized Hemoglobin 03/22/96
and Use Thereof
08/471,583 Method for Preserving a 06/07/95
Hemoglobin Blood Substitute
08/473,497 Method for Separating 06/07/95
Hemoglobin
08/360,149 Enzymatic Halogenation of 12/20/94
Cephalexin to Produce Cefaclor
and Other Halogenated Products
08/475,899 Separation of Polymerized from 06/07/95
Unpolymerized Hemoglobin on
Hydroxyapatite Using HPLC
08/673,147 A Method for Chromatographic 07/01/96
Removal of Prions
08/094,501 Method for Treating a Tumor 07/20/93
with a Chemotherapeutic Agent
08/477,110 Method for Treating a Tumor 06/07/95
with a Chemotherapeutic Agent
</TABLE>
-3-
<PAGE> 5
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FORM PTO-1595 U.S. DEPARTMENT OF COMMERCE
(Rev. 6-93) Patent and Trademark Office
RECORDATION FORM COVER SHEET
PATENTS ONLY
Attorney Docket No.: 014877-0000
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To the Commissioner of Patents and Trademarks:
Please record the attached original documents
or copy thereof. ATTN: BOX ASSIGNMENT
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1. Name of conveying party(ies):
Biopure Corporation
Additional name(s) of conveying party(ies) attached?
|_| Yes |X| No
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2. Name and address of receiving party(ies):
Name: Pharmacia & Upjohn, Inc.
Internal Address:
Street Address: 7000 Portage Road,
City: Kalamazoo
State: Michigan Zip: 49001
Additional name(s) & address(es) attached?
|_| Yes |X| No
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3. Nature of conveyance:
|_| Assignment |_| Merger
|X| Security Agreement |_| Change of Name
|_| Other
Execution Date: October 7, 1996
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4. Application number(s) or patent number(s):
If this document is being filed together with a new application the execution
date of the application is:
A. Patent Application No.(s) 08/209,949, 08/333,623, 08/477,916, 08/360,143,
08/409,337, 08/458,916, 08/484,775, 08/478,004,
08/487,288, 08/620,296, 08/471,583, 08/473,497,
08/360,149, 08/475,899, 08/673,147, 08/094,501
and 08/477,110
B. Patent No.(s) 5,084,558, 5,296,465, 5,095,765 and 5,295,944
Additional numbers attached: |_| Yes |X| No
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5. Name and address of party to whom correspondence
concerning document should be mailed:
Name: Mr. Matthew T. Bailey
Internal Address: Morgan, Lewis & Bockius LLP
Street Address: 1800 M Street, N.W.
City: Washington State: D.C. Zip: 20036
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6. Total number of applications and patents involved: 21
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7. Total fee (37 C.F.R ss.3.41): $840.00
|X| Enclosed
|_| Authorized to be charged to deposit account 13-4520
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8. Deposit account number: 13-4520
Attach duplicate of page if paying by deposit account
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9. Statement and Signature
To the best of my knowledge and belief, the foregoing information is true
and correct and any attached copy is a true copy of the original document.
Matthew T. Bailey /s/ Matthew T. Bailey October 11, 1996
-------------------------------- --------------------- ----------------
Name of Person Signing Signature Date
Total number of pages including cover sheet, attachments and documents: 4
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