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Sample Business Contracts

Common Stock Purchase Agreement - America's Doctor Inc., Medical Advisory Systems Inc. and Premier Research Worldwide Ltd.

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                        COMMON STOCK PURCHASE AGREEMENT

                                     Among

                            AMERICA'S DOCTOR, INC.,

                         MEDICAL ADVISORY SYSTEMS, INC.

                                      and

                        PREMIER RESEARCH WORLDWIDE, LTD.

                               Dated July 2, 1998
<PAGE>

         COMMON STOCK PURCHASE AGREEMENT, dated July 2, 1998, between AMERICA'S
DOCTOR, INC., a Delaware corporation (the "Company"), and MEDICAL ADVISORY
SYSTEMS, INC., a Delaware corporation ("MAS"), and PREMIER RESEARCH WORLDWIDE,
LTD., a Delaware corporation ("PRWW"). MAS and PRWW are at times herein
individually referred to as a "Purchaser" and collectively as the "Purchasers".

         WHEREAS the Company wishes to issue and sell to each Purchaser an
aggregate of 50,000 shares of Series A Common Stock, $0.01 par value, of the
Company (the "Stock"), at a purchase price of $20 per share, payable as provided
herein;

         WHEREAS each Purchaser wishes to purchase said shares, all on the terms
and subject to the conditions hereinafter set forth;

         NOW, THEREFORE, in consideration of the promises and the mutual
covenants herein contained, the parties hereby agree as follows:

                                       I.

                                   THE SHARES

         SECTION 1.01 Purchase and Sale of the Shares.

         (a) Subject to the terms and conditions set forth herein, the Company
shall sell to each Purchaser, and each Purchaser shall purchase from the
Company, on the Closing Date, 50,000 authorized but unissued shares of Stock
(said shares being herein called the "Shares") at a purchase price of $20 per
share for an aggregate purchase price equal to $1,000,000, and the Company shall
issue and deliver a stock certificate or certificates in definitive form,
registered in the name of the Purchaser, evidencing the Shares being purchased
by it hereunder.

<PAGE>

         (b) As payment in full for the Shares to be purchased by it, and
against delivery of the stock certificate or certificates therefor as aforesaid,
PRWW shall deliver to the Company on the Closing Date a certified or official
bank check in Philadelphia Clearing House funds payable to the order of the
Company in the amount of $1,000,000, or shall transfer such sum to the account
of the Company by wire transfer.

         (c) As payment in full for the Shares to be purchased by MAS hereunder,
MAS shall:

             (i) Provide to the Company during the Pre-Start-Up Period (as such
term is defined in the MAS Service Agreement referred to in paragraph 4(i)
below) the systems hardware, software and ongoing support specified more fully
in paragraph 13(a) of the MAS Service Agreement, for which MAS shall receive a
credit of $360,000, representing the purchase price for 18,000 shares of the
Stock hereunder; and

             (ii) Make the twelve consecutive monthly payments specified below
(with the first such payment due in the month following the end of the
Pre-Start-Up Period), representing payment of the purchase price for the
indicated number of shares of the Stock:

                  A. Eleven monthly payments of $53,320 each, each representing
the purchase price for 2,666 shares.

                  B. A twelfth payment of $53,480, representing the purchase
price for 2,674 shares.

         At the Closing, the Company shall execute 13 stock certificates
representing the respective shares of the Stock, the purchase price for which is
to be satisfied by MAS pursuant to clauses (i) and (ii) above. The Company shall
deliver each such certificate to MAS as the

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<PAGE>

purchase price for the Stock represented thereby has been satisfied or paid in
accordance with the above provisions.

         SECTION 1.02 Closing Date. The closing of the sale and purchase of the
Shares shall take place at the office of Archer & Greiner, A Professional
Corporation, One Centennial Square, Haddonfield, New Jersey 08033, at 10:00
a.m., on July 2, 1998, or at such other date and time as may be mutually agreed
upon between the Purchasers and the Company (such date and time of closing being
herein called the "Closing Date").

                                      II.

                 REPRESENTATIONS AND WARRANTIES OF THE COMPANY

         The Company represents and warrants to the Purchasers as follows:

         SECTION 2.01 Organization, Qualifications and Corporate Power. The
Company is a corporation duly incorporated, validly existing and in good
standing under the laws of the State of Delaware, and is duly licensed or
qualified as a foreign corporation in each other jurisdiction in which the
nature of the business transacted by it or the character of the properties owned
or leased by it makes such licensing or qualification necessary and where the
failure to be so qualified would have a material adverse effect upon the
business or assets of the Company. The Company has the corporate power and
authority to own and hold its properties and to carry on its business as
currently conducted, to execute, deliver and perform this Agreement, the
Registration Rights Agreement, the PRWW Service Agreement, the MAS Service
Agreement, the Stockholders Agreement and the Warrants (as such terms are
defined in Article IV or VI below) (collectively, the "Operative Documents"),
and to issue, sell and deliver the Shares and the Warrant Shares. The copies of
the Company's Certificate of

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Incorporation and by-laws heretofore delivered to the Purchasers are complete
and correct. The Company does not own any capital stock of or other equity
interest in any other corporation or organization.

         SECTION 2.02 Authorization of Agreement, Etc.

         (a) The execution, delivery and performance by the Company of the
Operative Documents and the issuance, sale and delivery of the Shares and the
Warrant Shares, have been fully authorized by all requisite corporate action and
will not violate any provision of law, any order of any court or other agency of
government, the Certificate of Incorporation or Bylaws of the Company, or any
provision of any indenture, agreement or other instrument by which the Company
or any of its properties or assets is bound or affected, or conflict with,
result in a breach of or constitute (with due notice or lapse of time or both) a
default under any such indenture, agreement or other instrument, or result in
the creation or imposition of any lien, charge or encumbrance of any nature
whatsoever upon any of the properties or assets of the Company.

         (b) The Shares and the Warrant Shares have been duly authorized and,
when issued and delivered in accordance with this Agreement or the Warrant (as
applicable), will be validly issued, fully paid and non-assessable shares of
Stock. The issuance, sale and delivery of the Shares and the Warrant Shares is
not subject to any preemptive rights of shareholders of the Company or to any
right of first refusal or other similar right in favor of any person.

         SECTION 2.03 Validity. This Agreement has been fully executed and
delivered by the Company and constitutes the legal, valid and binding obligation
of the Company, enforceable in accordance with its terms. The other Operative
Documents, when executed and

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<PAGE>

delivered in accordance with this Agreement, will constitute the legal, valid
and binding obligation of the Company, enforceable in accordance with their
respective terms.

         SECTION 2.04 Capital Stock. The authorized capital stock of the Company
consists of 1,000,000 shares of the Stock. The shareholders of the Company and
the number of shares of capital stock owned by each are set forth in Schedule
2.04A hereto. Except for the options, warrants and convertible unsecured
promissory notes, the terms of which are fully described in Schedule 2.04B
hereto, (i) no subscription, warrant, option, convertible security or other
right (contingent or other) to purchase or acquire any shares of any class of
capital stock of the Company is authorized or outstanding, (ii) there is not any
commitment of the Company to issue any shares, warrants, options or other such
rights or to distribute to holders of any class of its capital stock any
evidences of indebtedness or assets, (iii) the Company has no obligation
(contingent or other) to purchase, redeem or otherwise acquire any shares of its
capital stock or any interest therein or to pay any dividend or make any other
distribution in respect thereof, and (iv) to the Company's knowledge, there are
no existing rights of first refusal, registration rights or voting agreements
with respect to any of the Company's outstanding shares, except as described on
Schedule 2.04C. A true and correct copy of the Stock Option Agreement to Scott
Rifkin, M.D., is set forth as Schedule 2.04D. All of the outstanding shares of
the Stock have been issued in compliance with all applicable Federal securities
law.

         SECTION 2.05 Financial and Other Data. All financial and other data
pertaining to the Company and its business, assets and affairs, which has been
or hereafter prior to the Closing shall be furnished to either Purchaser by the
Company, are or will be at the time the same are so furnished, true, accurate
and complete in all material respects. To the best



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<PAGE>

knowledge and belief of the Company, except as described herein or in the
Business Plan (as defined below), the Company has no obligations or liabilities,
absolute, accrued or contingent, which in accordance with generally accepted
accounting principles should be listed on a balance sheet or described on the
notes thereto. To the date hereof, the Company has operated in a pre-start-up
phase consistent with the Business Plan.

         SECTION 2.06 Events Subsequent to January 1, 1998. Since January 1,
1998 except as set forth in Schedule 2.06 hereto, the Company has not (i) issued
any stock, bonds or other corporate securities, (ii) borrowed any amount or
incurred any liabilities (absolute or contingent), except current liabilities
incurred, and liabilities under contracts entered into, in the ordinary course
of business, none of which, individually or in the aggregate, are material to
the Company, (iii) discharged or satisfied any lien or incurred or paid any
obligation or liability (absolute or contingent) other than current liabilities
incurred in the ordinary course of business, (iv) declared or made any payment
or distribution to shareholders or purchased or redeemed any shares of its
capital stock or other securities, (v) mortgaged, pledged or subjected to lien
any of its assets, tangible or intangible, other than liens of taxes not yet due
and payable, (vi) sold, assigned or transferred any of its tangible assets,
except in the ordinary course of business, or canceled any debts or claims,
(vii) sold, assigned or transferred any patents, trademarks, trade names,
copyrights, trade secrets or other intangible assets, (viii) suffered any
losses, or waived any rights of substantial value, whether or not in the
ordinary course of business, (ix) made any changes in officer compensation,
except in the ordinary course of business and consistent with past practice, or
(x) entered into any transaction except in the ordinary course of business
(recognizing that the Company is in a start-up phase of its



                                      -6-
<PAGE>

business). Since such date, except as set forth in said Schedule 2.06, there has
been no material change in the accounting methods or practices of the Company.

         Between the date hereof and the Closing Date, the Company will not do
any of the things listed in Section 2.06 above, except as contemplated by
Schedule 2.06 hereto.

         SECTION 2.07 Actions Pending. There is no action, suit, investigation
or proceeding pending or, to the knowledge of the Company, threatened against or
affecting the Company or any of its properties or rights, before any court or by
or before any governmental body or arbitration board or tribunal. To the best
knowledge and belief of the Company, there does not exist any basis for any such
action, suit, investigation or proceeding. The foregoing includes, without
limiting its generality, actions pending or threatened (or any basis therefor
known to the Company) involving the prior employment of any employees or
prospective employees of the Company or their use, in connection with the
Company's business, of any information or techniques which might be alleged to
be proprietary to their former employers. There are no decrees, injunctions or
orders of any court or governmental department or agency outstanding against the
Company.

         SECTION 2.08 Trade Secrets. No third party has claimed that any person
affiliated with the Company has, in respect of his activities to date, violated
any of the terms or conditions of his employment contract with such third party,
or disclosed or utilized any trade secrets or proprietary information or
documentation of such third party, or interfered in the employment relationship
between such third party and any of its employees. The Company is not aware that
any person affiliated with it has employed or will employ any trade secrets or
any information or documentation proprietary to any former employer, or that
any person


                                       -7-
<PAGE>

affiliated with the Company has violated any confidential relationship which
such person may have had with any third party, in connection with the
development, manufacture and sale of any products of the Company. To the
Company's knowledge, there is no infringement by the Company of any third party
intellectual property right. All employees of the Company with access to
confidential information and who have executed employment agreements have
executed and delivered to the Company a non-disclosure and non-competition
agreement.

         SECTION 2.09 Title to Properties. The Company has good and marketable
title to all its real property and owns outright all its other properties and
assets, free and clear of mortgages/pledges, security interests, liens, charges
and other encumbrances, except (i) as described in Schedule 2.09 hereto, (ii)
liens for current taxes not yet due and (iii) minor imperfections of title, if
any, not material in amount and not materially detracting from the value or
impairing the use of the property subject thereto or impairing the operations or
proposed operations of the Company.

         SECTION 2.10 Leasehold Interests. Each lease or agreement to which the
Company is a party under which it is a lessee of any property, real or personal,
owned by any third party is a valid and subsisting agreement, without any
default of the Company thereunder and, to the best knowledge and belief of the
Company, without any default thereunder of the other party thereto. The
Company's possession of such property has not been disturbed nor has any claim
been asserted against the Company adverse to its rights in such leasehold
interests,

         SECTION 2.11 Taxes. The Company has filed or caused to be filed all
Federal, state and local tax returns and reports which are required to be filed
and has paid or caused to be paid all taxes as shown on all Federal, state and
local tax returns filed by it or on any

                                      -8-
<PAGE>

assessment received by it to the extent that such taxes have become due, and all
of the foregoing are correct and complete in all material respects. All accruals
for taxes owed by the Company are adequately reflected on the financial
statements described in Section 2.05 above. No issues have been raised or
deficiencies asserted by any taxing authority with respect to the Company's tax
liabilities or any of its tax returns or reports.

         SECTION 2.12 Patents, Trademarks, Etc. To the best knowledge and belief
of the Company, the Company owns the patents, trademarks, service marks, trade
names, copyrights and licenses listed in Schedule 2.12 hereto without conflict
with the rights of others, the same constitute all the patents, trademarks,
service marks, trade names, copyrights and licenses necessary in the conduct of
the business of the Company, and, except as indicated in said Schedule 2.12,
there exists no right of any person to receive a royalty with respect thereto or
to utilize or otherwise appropriate the same, and the Company has no
distribution, marketing or other agreements granting rights to third parties
relating in whole or in part to any items of the foregoing categories, except
licenses granted in the ordinary course of its business. All technical
information developed by and belonging to the Company which has not been
patented by it is and will continue to be protected by measures deemed prudent
by the Company for the maintenance of secrecy relating thereto.

         SECTION 2.13 Governmental Approvals. No registration or filing with, or
consent or approval of, or other action by, any Federal, state or other
governmental agency or instrumentality is or will be necessary for the valid
execution, delivery and performance of the Operative Documents and the issuance,
sale and delivery of the Shares, the Warrants and the Warrant Shares hereunder.



                                      -9-
<PAGE>

         SECTION 2.14 Use of Proceeds. Unless otherwise agreed to by the PRWW
board representative, the Company will apply the proceeds of the issuance and
sale of the Shares for start up and operating costs as described in the Business
Plan. In no event will the proceeds of the issuance and sale of the Shares to
PRWW be utilized to retire any portion of the Bridge Loan (as defined in
subparagraph (k) of Article IV below).

         SECTION 2.15 Disclosure. The Company has furnished to the Purchasers a
copy of the Company's business plan attached as Schedule 2.15A, used in
connection with its offer of the Shares (the "Business Plan"). In addition, the
Purchasers have had lengthy discussions regarding this investment and the
Company in general with representatives of the Company. To the Company's best
knowledge and belief, after due inquiry, the Business Plan and this Agreement do
not contain any untrue statement of material fact or omit to state any material
fact necessary in order to make the statements contained therein or herein, in
light of the circumstances under which they are made, not misleading. The
projections of financial results contained in the Business Plan were in all
material respects prepared accurately based upon the assumptions described
therein, which assumptions the Company believes to be realistic. The Company is
a start-up company without any meaningful financial or operating history and the
Purchasers were made aware of the speculative nature and high degree of risk of
loss involved with this purchase as set forth in Schedule 2.15B hereto.

         SECTION 2.16 Offering of the Shares. Neither the Company nor any person
authorized or employed by the Company as agent, broker, dealer or otherwise in
connection with the offering or sale of the Shares or any similar security of
the Company has offered the Shares or any such security for sale to, or
solicited any offers to buy the Shares or any similar




                                      -10-
<PAGE>

security of the Company from, or otherwise approached or negotiated with respect
thereto with, any person or persons other than the Purchasers and not more than
35 non-accredited investors (including, if applicable, the Purchasers). Neither
the Company nor any person acting on its behalf has taken or will take any
action (including, without limitation, any offer, issuance or sale of any
security of the Company, pursuant to the Business Plan or otherwise), under
circumstances which might require the integration of such security with the
Shares under the Securities Act of 1933 (the "Securities Act") or the rules and
regulations of the Securities and Exchange Commission (the "Commission")
thereunder which might subject the offering, issuance or sale of the Shares to
the registration provisions of the Securities Act. The offering, issuance and
sale of the Shares hereunder is exempt from the federal registration
requirements.

         SECTION 2.17 Employment Contracts, Etc.; Certain Material
Transactions. Except as set forth in Schedule 2.17 hereto, (i) the Company is
not a party to any employment or deferred compensation agreements, (ii) the
Company does not have any bonus, incentive or profit-sharing plans, (iii) the
Company does not have any pension, retirement or similar plans or obligations,
and (iv) there are no existing material arrangements or proposed material
transactions between the Company and any officer or director or holder of more
than 10% of the capital stock of the Company. The Company is not a party to any
collective bargaining agreement and, to the best of its knowledge, no
organizational efforts are currently being made with respect to any of its
employees. Any employment agreements to be entered into in the future or
contemplated and listed on Schedule 2.17 but not executed on or before the
Closing Date, will be approved by the Company's Compensation Committee.




                                      -11-
<PAGE>

         SECTION 2.18 Other Contracts and Commitments. The Company is not in
default in the performance, observance or fulfillment of any of the obligations,
covenants or conditions contained in the Company's Certificate of Incorporation
or by-laws or in any agreement or instrument to which it is a party which may
result in any material adverse change in the condition, financial or other, of
the Company, and, to the best knowledge and belief of the Company, there are no
existing such defaults by the other parties thereto. Attached hereto as Schedule
2.18 is a true, complete and correct copy of the Interactive Services Agreement
between the Company and America Online, Inc. (the "AOL Agreement"). The AOL
Agreement is a valid and subsisting agreement, and no default has occurred
thereunder by the Company or AOL.

         SECTION 2.19 Compliance With Law. The Company is not in default under
any order of any court, governmental authority or arbitration board or tribunal
to which the Company is or was subject or in violation of any laws, ordinances,
governmental rules or regulations to which the Company is or was subject, except
for such violations which do not, individually or in the aggregate, have a
material adverse effect on the Company. The Company has not failed to obtain any
licenses, permits, franchises or other governmental authorizations necessary to
the ownership of the properties of the Company or to the conduct of the business
of the Company and the failure of which to obtain would have a material adverse
effect on the Company.

         SECTION 2.20 Employee Benefits Plans. The Company has never been a
party to a multi-employer retirement plan. The Company has no Employee Benefit
Plans subject to the






                                      -12-

<PAGE>

provisions of the Employee Retirement Income Security Act of 1974 (as such term
is defined therein).

         SECTION 2.21 Insurance. The Company maintains insurance with
responsible and reputable insurance companies in such amounts and covering such
risks as is usually carried by companies engaged in similar businesses and
owning similar properties in the same general area in which the Company operates
or owns such properties.  

                                      III.

                REPRESENTATIONS AND WARRANTIES OF EACH PURCHASER

         Each Purchaser represents and warrants to the Company (for itself and
not for the other Purchaser) that it is acquiring the Shares for its own account
for the purpose of investment and not with a view to or for sale in connection
with any distribution thereof. Each Purchaser represents and warrants that it is
an "accredited investor" as such term is defined under the Securities Act of
1933, as amended (the "Securities Act") or that it has sufficient knowledge and
experience in financial and business matters to be capable of evaluating the
merits and risks of this purchase. Each Purchaser further represents that it
understands that (i) the Shares have not been registered under the Securities
Act by reason of their issuance in a transaction exempt from the registration
requirements of the Securities Act pursuant to Section 4(2) and 4(6) thereof,
(ii) the Shares must be held indefinitely unless a subsequent disposition
thereof is registered under the Securities Act or is exempt from such
registration, (iii) the Shares will bear a legend to such effect (to be removed
when such restrictions are no longer applicable), and (iv) the Company will make
a notation on its transfer books to such effect. The Purchaser further
understands that the exemption from registration afforded by Rule 144 under the





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<PAGE>

Securities Act depends on the satisfaction of various conditions and that, if
applicable, Rule 144 affords the basis of sales of the Shares in limited amounts
under certain conditions. The Purchaser acknowledges that it has had a full
opportunity to request from the Company all instruments, documents, records and
books pertaining to this investment, all of which requested documentation has
been made available by the Company, and the Purchaser has received such
information that it deems relevant in making a decision to purchase the Shares
being purchased by it hereunder. The Purchaser has had the full and fair
opportunity to have the Company's Business Plan, other documents and this
Agreement reviewed thoroughly by independent, competent advisors and counsel or,
if not, then the Purchaser has made the fully informed, independent decision not
to do so, and the Purchaser has duly considered the factors listed on Schedule
2.15 hereto (provided that the review and receipt of any such information shall
not in any manner qualify or diminish the representations of the Company
contained in Article II). The Purchaser will comply with any restrictions on
transferability of the Shares contained in the Registration Rights Agreement and
the Stockholders Agreement.

                                      IV.

                         CONDITIONS TO THE OBLIGATIONS
                                OF EACH PURCHASER

         The obligation of each Purchaser to purchase and pay for the Shares
being purchased by it on the Closing Date is, at its option, subject to the
simultaneous Closing of the purchase of Shares hereunder by the other Purchaser
and, at its option, is further subject to the satisfaction, on or before such
date, of the following conditions:



                                      -14-
<PAGE>


         (a) Opinion of Counsel. The Purchaser shall have received from Rifkin,
Livingston, Levitan & Silver, LLC, counsel for the Company, an opinion dated the
Closing Date, in form and substance satisfactory to the Purchaser and its
counsel, to the effect that:

             (i) The Company is a corporation duly incorporated, validly
existing and in good standing under the laws of the State of Delaware. The
Company has the corporate power and authority to own and hold its properties and
to carry on its business as currently conducted, to execute, deliver and perform
the Operative Documents, and to issue, sell and deliver the Shares and the
Warrant Shares.

             (ii) The authorized capital stock of the Company consists of
1,000,000 shares of Series A Common Stock, of which 234,651 shares are
outstanding, which outstanding shares have been validly issued and are fully
paid and non-assessable.

             (iii) Such counsel, without independent investigation, is not aware
of any non-compliance with any Federal securities laws in connection with the
original issuance of the presently outstanding shares of the Company's capital
stock.

             (iv) The execution, delivery and performance by the Company of the
Operative Documents, and the issuance, sale and delivery of the Shares and the
Warrant Shares, have been duly authorized by all requisite corporate action, and
will not violate any provision of law, the Certificate of Incorporation or
by-laws of the Company or, to the knowledge of such counsel, without independent
investigation, any provision of any material agreement or other instrument by
which the Company or any of its properties or assets is bound or affected, or
conflict with, result in a breach of or constitute a default under any such
agreement or other instrument.



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<PAGE>

             (v) Each of the Operative Documents has been duly executed and
delivered by the Company and constitutes the legal, valid and binding obligation
of the Company, enforceable in accordance with its terms (subject, as to
enforcement of remedies, to applicable bankruptcy, reorganization, insolvency
and similar laws, to moratorium laws from time to time in effect and to general
equity principles), except that such counsel need express no opinion as to the
indemnification provisions of the Registration Rights Agreement.

             (vi) The Shares have been issued, sold and delivered by the Company
pursuant to this Agreement and are duly authorized, validly issued, fully paid
and nonassessable shares of Stock.

             (vii) The issuance, sale and delivery of the Shares to the
Purchaser, under the circumstances contemplated by this Agreement, are exempt
from the registration requirements of the Federal securities laws.

             (viii) Such counsel does not represent the Company with respect to
pending or overtly threatened litigation, and to its knowledge without
independent investigation there is no such pending or threatened litigation
outstanding.

             (ix) Such counsel is not aware of any material default by the
Company under any agreement or instrument of the Company or any failure by the
Company to comply with applicable law.

             (x) To the knowledge of such counsel, all consents and approvals
required for the execution, delivery and performance by the Company of this
Agreement have been duly obtained.




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<PAGE>

         (b) Representations and Warranties to be True and Correct; Performance.
The representations and warranties contained in Article II hereof shall be true
and correct on and as of the Closing Date with the same effect as though such
representations and warranties had been made on and as of such date; the Company
shall have performed and complied with all agreements and conditions contained
herein required to be performed or complied with by it prior to or at the
Closing Date; and each Purchaser shall have received a certificate dated the
Closing Date, executed by the Company's president or vice president, to each
such effect.

         (c) Consents and Approvals. All necessary consents and approvals from
governmental and third parties required for the sale and issuance of the Shares
hereunder and the other actions contemplated hereby shall have been duly
obtained.

         (d) Secretary's Certificate. Each Purchaser shall have received a
certificate from the Secretary or Assistant Secretary of the Company, with
respect to the Company's Certificate of Incorporation and by-laws and
resolutions of the Company's Board of Directors authorizing the transactions
contemplated hereby.

         (e) Election of Directors. Each Purchaser's designee shall have been
elected to the Company's Board of Directors.

         (f) Stockholders' and Voting Agreement. On the Closing Date, the
Company and the other parties thereto shall have executed and delivered the
Stockholders' and Voting Agreement among the Company and its shareholders, in
the form of Annex III hereto (the "Stockholders Agreement").

         (g) Registration Rights Agreement. On the Closing Date the Company
shall have executed and delivered the Registration Rights Agreement, in the form
of Annex IV hereto (the




                                      -17-
<PAGE>

"Registration Rights Agreement").

         (h) [RESERVED]

         (i) MAS Service Agreement. On the Closing Date, the Company and MAS
shall have executed and delivered the Services Agreement in the form of Annex V
hereto (the "MAS Service Agreement").

         (j) PRWW Service Agreement. On the Closing Date, the Company and PRWW
shall have executed and delivered the Services Agreement in the form of Annex VI
hereto (the "PRWW Service Agreement").

         (k) Bridge Loan. At or prior to the Closing, the Company shall have
received a $900,000 bridge loan from Mercantile Safe Deposit & Trust Co., on
terms and conditions satisfactory to each Purchaser, guaranteed by the
individuals listed on Schedule 4(k) hereto (the "Loan Guarantors"), for which
the Loan Guarantors shall receive in the aggregate warrants to acquire not more
than 7,500 shares of the Stock, on terms and conditions satisfactory to each
Purchaser.

         (1) Additional Equity Funding. Unless otherwise agreed to by the PRWW
board representative, at or prior to the Closing, the Company shall have issued
and sold 25,000 shares of the Stock to the individual investors listed in Part A
of Annex VII hereto (the "Wyndhurst Group"), for an aggregate consideration,
paid in cash, of $500,000, and shall have issued and sold 25,000 shares of the
Stock to the individual investors listed in Part B of said Annex (the "Seidman
Group"), for an aggregate consideration, paid in cash, of $500,000.




                                      -18-

<PAGE>

                                       V.

                  CONDITIONS TO THE OBLIGATIONS OF THE COMPANY

         The obligation of the Company to issue and sell the Shares to the
Purchasers on the Closing Date is, at its option, subject to the satisfaction,
on or before such date, of the following conditions:

         (a) Representations and Warranties to be True and Correct. The
representations and warranties contained in Article III hereof shall be true and
correct on and as of the Closing Date with the same effect as though such
representations and warranties had been made on and as of such date.

         (b) Operative Documents. The other parties thereto shall have executed
and delivered to the Company the Operative Documents.

         (c) Consents and Approvals. All necessary consents and approvals from
governmental and third parties required for the sale and issuance of the Shares
hereunder shall have been duly obtained.

                                      VI.

                ADDITIONAL EQUITY OFFERING; ISSUANCE OF WARRANTS

         SECTION 6.01 Equity Offering. The Company shall use its best efforts to
sell, within 45 days of the Closing Date, 150,000 shares of the Stock to as yet
undetermined investors (the "Prospective Investors"), for an aggregate
consideration of $3,000,000, payable in cash. Such issuance shall be on terms
(for example, purchase price, payment terms, registration rights, etc.) no more
favorable than those provided hereunder to MAS and PRWW.



                                      -19-
<PAGE>

         SECTION 6.02 Issuance of Warrants. On the 45th day following the
Closing Date, the Company will issue warrants to purchase its Stock,
substantially in the form an Annex VIII hereto (the "Warrants"), to PRWW, MAS,
the Wyndhurst Group and the Seidman Group, pro rata to the Stock owned by each.
The Warrants will permit the holder thereof to purchase the number of shares of
Stock represented thereby (herein, the "Warrant Shares"), at any time during a
10 year period, for a purchase price of $.01 per share. The aggregate number of
Warrant Shares issuable under all of the Warrants shall equal the result of (a)
$3,000,000, minus (b) the aggregate purchase price received from the Prospective
Investors, divided by (c) $3,000,000, multiplied by (d) 50,000 shares.

                                      VII.

                            COVENANTS OF THE COMPANY

         The Company covenants and agrees that, unless the Purchasers shall
otherwise consent in writing:

         (a) Financial Statements. The Company shall furnish to each Purchaser
the financial statements and other information required to be provided to
holders of the Common Stock pursuant to the Stockholders Agreement.

         (b) Insurance. The Company will maintain insurance with responsible and
reputable insurance companies in such amounts and covering such risks as is
usually carried by companies engaged in similar businesses and owning similar
properties in the same general area in which the Company operates or owns such
properties.




                                      -20-
<PAGE>

         (c) Key Man Insurance. The Company will use best efforts to obtain
within 90 days of the Closing Date, and thereafter will maintain in effect, key
man life insurance in an amount of not less than $1,000,000 on the life of its
CEO.

         (d) Non-Disclosure Agreements. The Company will maintain in effect with
each of its employees who are privy to confidential information of the Company,
and who have or shall execute an employment agreement, a covenant, in form and
substance reasonably deemed to be appropriate by the Company, pursuant to which
each such employee shall agree not to disclose or utilize confidential or
proprietary information of the Company or to compete with the Company.

         (e) Access to Records. The Company shall afford to each Purchaser and
its employees, counsel and other authorized representatives free and full
access, on a reasonable basis during normal business hours, to all of the books,
records and properties of the Company and to all officers and employees of the
Company for any reasonable purpose whatsoever; provided that such free and full
access does not unreasonably interfere with the normal business operations of
the Company. The Purchaser'shall use its best efforts to maintain the
confidentiality of any confidential and proprietary information so obtained by
it which is not otherwise available from other sources; provided, however, that
the foregoing shall in no way limit or otherwise restrict the ability of the
Purchaser or such authorized representatives to disclose any such information
concerning the Company which it may be required to disclose (i) to its partners
to the extent required to satisfy its fiduciary obligations to such persons, or
(ii) otherwise pursuant to or required by law.



                                      -21-
<PAGE>

         (f) Budgets and Operating Forecast. The Company will promptly provide
each Purchaser will copies of any budgets which it may from time to time adopt,
which in any event shall include an annual budget to be prepared and distributed
not later than 45 days after the commencement of each fiscal year.

         (g) Existence; Maintenance of Property. The Company shall do or cause
to be done all things necessary to maintain, preserve and keep in full force and
effect its corporate existence and all rights, licenses, permits and franchises
necessary to the proper conduct of its business and the ownership, leasing or
operation of its properties. The Company shall maintain and operate its
business and properties in accordance with all applicable laws and regulations
and take all reasonable action which may be required to obtain, preserve, renew
and extend all licenses, permits, authorizations, trade names, trademarks,
copyrights and patents which may be necessary for the continuance of the
operation of any such property by it. The Company shall at all times maintain
and preserve all property necessary in the conduct of its business and keep the
same in good repair, working order and condition, and from time to time make, or
cause to be made, all necessary and proper repairs, renewals, replacements,
betterments and improvements thereto so that the business carried on in
connection therewith may properly and advantageously be conducted at all times.

         (h) Payment of Debts, Taxes, Etc. The Company shall pay all
indebtedness and obligations promptly and in accordance with normal terms and
pay and discharge promptly all taxes, assessments and governmental charges or
liens imposed upon it or upon its income or receipts or in respect of any of its
property, before the same shall become in default, as well as all lawful claims
which, if unpaid, might result in the creation of a lien or charge upon such




                                      -22-
<PAGE>

properties or any part thereof; provided, however, that the Company shall not be
required to pay and discharge or to cause to be paid and discharged any such
indebtedness, obligation or tax so long as the validity or amount thereof shall
be contested in good faith and the Company shall set aside on its books such
reserves as are required by generally accepted accounting principles with
respect to any such indebtedness, obligation or tax.

         (i) Litigation or Other Notices. The Company shall deliver to each
Purchaser promptly following the occurrence thereof written notice of the
following:

             (A) all events of default under any of the terms or provisions of
any material note, or of any other evidence of material indebtedness or
agreement or contract governing the borrowing of money of the Company;

             (B) levy of an attachment, execution or other process against any
of the property or assets, real or personal, of the Company or any of its
subsidiaries, unless the same is reasonably discharged within thirty days and is
so discharged;

             (C) the filing or commencement of any action, suit or proceeding by
or before any court or any federal, state, municipal or other governmental
department, commission, instrumentality or agency which may result in material
liability to, or otherwise materially adversely affect, the Company;

             (D) any matter of non-general effect which has resulted in, or
which may result in, a material adverse change in the financial condition or
operations of the Company.

         (j) Performance of Obligations. The Company shall do and perform every
act and discharge all of the obligations required to be performed and discharged
under any of the Operative Documents at the time or times and in the manner
therein and herein specified.




                                      -23-
<PAGE>

         (k) Meetings of the Board of Directors. The Company shall call, and use
its best efforts to have, regular meetings of the Board of Directors of the
Company not less than quarterly.

         (l) Board of Directors; Membership Thereon. The Board of Directors
shall be of such size and composed of such designees as is more fully specified
in the Stockholders Agreement.


                                     VIII.

                                   [RESERVED]

                                       IX.

                                 MISCELLANEOUS

         SECTION 9.01 Expenses. Each party hereto will pay its own expenses in
connection with the transactions contemplated hereby, whether or not such
transactions shall be consummated, provided, however, that the Company shall pay
one half of the fees and disbursements of each Purchaser's counsel. With the
Purchasers' prior knowledge and approval, closing costs of this transaction
payable to third parties have been incurred by the Company which are to be
satisfied by (i) cash payments equal to 8% of the proceeds of the offering
hereunder due out of the offering and (ii) issuance of shares of the Common
Stock equal to 9% of the Company's Common Stock outstanding after the sale and
purchase hereunder; the cash payments will accrue until such time as the Company
has sufficient funds to pay this cost, at the prudent discretion of management.
The Company further confirms that its legal and accounting fees arising from
this offering shall not exceed $50,000.






                                      -24-
<PAGE>

         SECTION 9.02 Survival of Agreements. All covenants, agreements,
representations and warranties made herein shall survive the execution and
delivery of this Agreement and the issuance, sale and delivery of the Shares
pursuant hereto.

         SECTION 9.03 Brokerage. Each party hereto represents and warrants to
the other that it has incurred no brokerage or other commissions relative to
this Agreement or to the transactions contemplated hereby, based in any way on
agreements, arrangements or understandings made or claimed to have been made by
such party with any third party, except for the consulting fees payable by the
Company included within the closing costs referred to in Section 9.01 above.
Notwithstanding the foregoing, each party hereto will indemnify and hold
harmless the other against and in respect of any claim for brokerage or other
commissions relative to this Agreement or to the transactions contemplated
hereby (other than such consulting fees), based in any way on agreements,
arrangements or understandings made or claimed to have been made by such party
with any third party.

         SECTION 9.04 Parties in Interest. All covenants and agreements
contained in this Agreement by or on behalf of any of the parties hereto shall
bind and inure to the benefit of the parties hereto and their respective
successors and assigns.

         SECTION 9.05 Notices. All notices, requests, consents and other
communications hereunder shall be in writing and shall be mailed by first class
registered mail, postage prepaid, addressed as follows:

             (a) if to the Company, at:

                 11403 Cronridge Drive
                 Suite 200
                 Owings Mills, MD 21117


                                      -25-
<PAGE>

             (b) if to PRWW, at:

                 Premier Research Worldwide, Ltd.
                 124 S. 15th Street
                 Philadelphia, Pennsylvania 19102-3010
                 Attn: CEO



             (c) If to MAS, at:

                 8050 Southern Maryland Boulevard
                 Owings, MD 20736

or, in any such case, at such other address or addresses as shall have been
furnished in writing by such party to the others in accordance with this Section
9.05.

             SECTION 9.06 Law Governing Construction. This Agreement shall be
governed by and construed in accordance with the laws of the State of Maryland.
In the event any provision of this Agreement shall be held to be invalid or
unenforceable for any reason, such invalidity or unenforceability shall attach
only to such provision and shall not affect or render invalid or unenforceable
any other provision of this Agreement.

             SECTION 9.07 Entire Agreement. This Agreement constitutes the
entire Agreement of the parties with respect to the subject matter hereof and
may not be modified, waived or amended except in writing.

             SECTION 9.08 Counterparts. This Agreement may be executed in two or
more counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.



                                      -26-

<PAGE>

             IN WITNESS WHEREOF, the Company and the Purchaser have executed
this Agreement as of the day and year first above written.

                                            AMERICA'S DOCTOR, INC.             
                                                                              
                                            By /s/ Scott Rifkin
                                               -------------------------------
                                               President
                                           
                                           

                                            MEDICAL ADVISORY SYSTEMS, INC.
                                                                             
                                           
                                            By: /s/ Ronald Pickett
                                                ------------------------------
                                           

                                           
                                            PREMIER RESEARCH WORLDWIDE, L.T.D.
                                                                      
                                           
                                            By: /s/ Fred M. Powell
                                                -------------------------------


                                      -27-
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.22
<SEQUENCE>4
<DESCRIPTION>EXHIBIT 10.22
<TEXT>


<PAGE>

                         SUPPORT AND SERVICE AGREEMENT
                         -----------------------------

     THIS AGREEMENT, is made the 2nd day of July, 1998, by and between PREMIER
RESEARCH WORLDWIDE, LTD., a Delaware corporation with its principal place of
business located at 124 S. 15th Street, Philadelphia, PA 19102 (referred to
herein as "PRWW") and AMERICA'S DOCTOR, INC., a Delaware corporation with its
principal place of business located at 11403 Cronridge Drive, Suite 200, Owings
Mills, MD 21117 (referred to herein as "AD").

     WHEREAS, the parties hereto have entered into a Stock Purchase Agreement
dated as of July 1, 1998 (the "Stock Purchase Agreement") wherein PRWW has
purchased certain stock in AD pursuant to the terms of the Stock Purchase
Agreement; and

     WHEREAS, the parties hereto are entering into this Agreement pursuant to
and in connection with the Stock Purchase Agreement;

     NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, and intending to be legally bound,
the parties hereto agree as follows:

1.       DEFINITIONS

         1.1  "Services" shall mean the providing of support and services to
              PRWW by AD as set forth in Subsection 3.1 of this Agreement.

         1.2  "Term" shall mean the period of time during which this Agreement
              is in force.

         1.3  "Operative" shall mean the Services'conforming in all material
              respects to the performance levels and requirements detailed in
              this Agreement.

         1.4 "Effective Date" shall mean July 2, 1998.

         1.5  All other defined terms shall have the meanings ascribed to them
              in this Agreement.

2.       TERM AND TERMINATION

         2.1  The Term of this Agreement shall begin on the Effective Date and
              shall continue until this Agreement is terminated as provided in
              Subsection 2.2.

         2.2  This Agreement may be terminated as follows:

                (a) By the mutual, written agreement of the parties to terminate
         this Agreement; or

<PAGE>


                (b) On written notice by a party if the other party materially
         breaches any provision hereof and does not cure such breach within
         thirty (30) days after its receipt of written notice, specifying the
         breach, from the non-breaching party; or

                (c) On written notice by a party if the other party files a
         voluntary bankruptcy proceeding, becomes subject to an involuntary
         bankruptcy proceeding (which is not dismissed or stayed within 30 days
         of its commencement), becomes subject to a receiver or trustee, or
         makes an assignment for the benefit of its creditor; or

                (d) By PRWW without cause with sixty (60) days prior notice to
         AD; or

                (e) From and after the date that PRWW no longer owns at least I
         % of the outstanding voting stock of AD, by AD without cause with 60
         days prior notice to PRWW.

3. SUPPORT AND SERVICE PROVISIONS.

   3.1. AD agrees to provide the following to PRWW:

                (a) AD shall provide PRWW with direct links from all AD's
         existing and future website(s) (but not every page within such
         websites) to users to provide the following:

                      (i) ongoing solicitation and quantification of qualified
         clinical research organization (CRO) volunteer patients to participate
         in clinical/medical studies administered by PRWW; and'

                      (ii) education of the users on the societal merits of
         participating in clinical research.

                (b) AD shall promote and market PRWW's studies on line through
         use of its promotional space on its existing and future Health Main
         Page(s) to connect to promotional material for PRWW studies.

                      (i) As an example, AD will offer its AOL users daily and
         monthly themes such as "Heart Disease Prevention." Such promotional ads
         will be connected to a number of targeted choices for the AOL users. If
         the AOL user selects a PRWW targeted choice, the AOL user will be
         immediately connected to a PRWW targeted site (the "Targeted Site").

                                       2
<PAGE>

                      (ii) The Targeted Site will be created by AD specifically
         for PRWW under the supervision of and pursuant to the sole discretion
         of PRWW (AD having the right not to follow PRWW's directions if the
         same would be detrimental in any material respect to AD's image or
         business plan). The Targeted Site will give the AOL user appropriate
         information about PRWW's clinical research activities. If the AOL user
         wishes to volunteer, the AOL user will make a choice by clicking an
         icon and will be led automatically and immediately to a form to
         complete (the "Form" or "Forms" as the context may require). The Form
         will be created by AD specifically for PRWW under the supervision of
         and pursuant to the sole discretion of PRWW. The Form will gather the
         information which PRWW needs for its own purposes and will be varied
         within reason from study to study at the sole discretion of PRWW. AD
         shall provide all such completed forms to PRWW by e-mail or other
         agreedupon means on a daily basis. AD will also provide to PRWW monthly
         statistical summaries of the information gathered on the Forms as well
         as its updated monthly databases.

    3.2. PRWW agrees to provide the following to AD:

                (a) Introductions to the Premier Hospital Group and other
         related healthcare organizations;

                (b) Introductions to the pharmaceutical, medical instrument
         companies, and other organizations with which PRWW has an ongoing
         business relationship (PRWW representing that it has relationships with
         at least twenty such entities).

    4.   EXCLUSIVITY/CONFIDENTIALITY

         4.1  AD shall provide the above described Services exclusively to PRWW
              and shall not provide similar services to any other person or
              entity relating to recruitment for clinical trials.

         4.2  AD shall not design or provide any program that is in any way
              substantially similar or related to the program provided to PRWW
              for or in conjunction with any other person or entity relating to
              recruitment for clinical trials without the express written
              permission of PRWW.

         4.3  All materials, documents, and other information shared with PRYM
              by AD during the course of this Agreement shall be deemed to be,
              between AD and PRWW, confidential information ("Information") and
              AD shall share same only with those persons performing hereunder
              who have a need-to-know same in order to perform the Services.
              Upon termination of this Agreement, all Information provided to
              PRWW by AD hereunder shall continue to be the

                                       3
<PAGE>

              exclusive property of PRWW. AD shall be liable for any
              unauthorized use or disclosure of the Information by AD's
              employees which could have reasonably been prevented by AD.

         4.4  AD represents, warrants, covenants and agrees that it shall
              maintain reasonable safeguards against the destruction, loss or
              alteration of information and data under its control and required
              to be provided to PRWW hereunder.

         4.5  AD shall not, without the prior written approval of PRWW, publicly
              disclose in any press release, filing, brochure or document any
              information pertaining to this Agreement (it being understood that
              AD may disclose this Agreement to potential investors).

         4.6  Nothing herein confers or shall confer upon PRWW any right, title
              or interest in any goodwill, trademark, trade name, brand name,
              knowledge or credibility of AD. PRWW acknowledges that all such
              interests are the exclusive property of AD. PRWW shall not assert
              any claim of ownership or right to the same.

         4.7  Nothing herein confers or shall confer upon AD, any right, title
              or interest in any goodwill, trademark, trade name, brand name,
              knowledge or credibility of PRWW. AD acknowledges that all such
              interests are the exclusive property of PRWW. AD shall not assert
              any claim of ownership or right to same.

      5. GENERAL PROVISIONS

         5.1  Each party hereto shall indemnify and hold the other party and its
              directors, officers, employees, agents, subsidiaries, parents,
              affiliates, consultants and subcontractors (all "Associates")
              harmless from any claim, liability, loss, damages or expense,
              together with all reasonable costs and expenses relating thereto-,
              including reasonable attorneys' fees, resulting from the
              negligent, reckless or willful acts or omissions of such party,
              its agents or employees in connection with the providing of the
              Services hereunder.

         5.2  Each party hereto shall indemnify and hold the other party and its
              Asgociates harmless from any and all claim, liability, loss,
              damages or expense, together with all reasonable costs and
              expenses relating thereto, including reasonable attorneys' fees,
              arising out of or resulting from any breach of any representation,
              warranty, covenant or obligation of such party contained in this
              Agreement.

         5.3  Each party hereto shall indemnify and hold the other party and its
              Associates harmless from any and all claim, liability, loss,
              damages or expense, together with all reasonable costs and
              expenses relating thereto, including reasonable

                                       4
<PAGE>
              attorneys' fees, arising from a claim that the Services provided
              by such party, or any part thereof, infringes a patent, copyright,
              trade secret or other intellectual property right of a third
              party.

         5.4  Each party hereto shall promptly notify the other party in writing
              of the assertion of any claim, liability, loss, damages or expense
              described in this Section 5. The indemnifying party shall have the
              exclusive right to control the defense and settlement of such
              claim, and the indemnified party and its Associates shall
              cooperate and provide all reasonable information, assistance and
              authority to enable the indemnifying party to conduct such
              defense.

         5.5  In the event that the Services provided by a party hereunder, or
              any part thereof, are found to infringe a patent, copyright or
              other intellectual property right, such party shall, in addition
              to the indemnity provided above, take the following actions at its
              expense: (a) procure for the other party the right to continue to
              use the Services; or (b) if such cure is not made available
              despite such party's best efforts to secure same, replace or
              modify the offending element(s) of the Services provided for
              hereunder by such party, so that it/they are no longer infringing
              while still meeting the requirements of this Agreement. A party
              shall not have liability hereunder for any claim based on the
              other party or its Associates' misuse of any product or use or
              combination of any product with software, hardware or other
              materials.

         5.6  The parties respective rights and obligations under Sections 4.3,
              4.4, 4.5, 4.6 and 4.7 hereof and this Section 5 shall survive any
              expiration or termination of this Agreement.

      6. ADDITIONAL COVENANTS, REPRESENTATIONS AND WARRANTIES

         6.1  AD represents that AOL has represented to it that AOL has
              approximately 32 million impressions per year on the Health Main
              Page. This represents the number of times per year that an AOL
              user enters the Health Main Page screen each year.

         6.2  AD represents that AOL has represented to it that IntelliHealth,
              an AOL Health Main Page Anchor Tenant without real time medical
              services, is running 2.5 - 3.0 million page impressions per month.

         6.3  AD represents that the users of the Health Main Page and the
              Anchor Tenants of the Health Main Page are within a demographic
              group from which volunteers of the nature needed by PRWW are
              typically found.

                                        5
<PAGE>

6.4     AD represents that it is an anchor tenant on the AOL Health Main Page.
        AD anticipates more than 500,000 users in its first month of operations
        as an Anchor Tenant on AOL's Health Main Page based upon discussions
        with AOL and representatives of other Health Main Page Anchor Tenants.

6.5     AD shall use its best efforts to perform the Services hereunder pursuant
        to the highest standards in the industry.

6.6     AD will designate and at all times use its best efforts to maintain its
        facility, equipment and service personnel in a manner necessary to
        provide the Services to PRWW as contemplated in this Agreement.

6.7     AD shall designate and maintain at all times a specific contact person
        located at the offices of AD who will have primary responsibility to
        respond, or facilitate the response, to telephone requests for Service
        by PRWW.

6.8     AD represents, warrants, covenants and agrees that AD's personnel
        performing hereunder are and shall be skilled in the providing of the
        Services.

6.9     AD represents, warrants, covenants and agrees that it has in effect, and
        shall use its best efforts to establish and maintain in effect during
        the term of this Agreement, all hardware, software, firmware and other
        intellectual property license and support agreements (including, without
        limitation, those agreements necessary to secure access to and use of
        new release levels, amendments, improvements and updates to such
        hardware, software, firmware and other intellectual property) as are
        necessary to lawfully and properly provide the Services.

6.10    AD represents, warrants, covenants and agrees that it currently, and
        shall for the term of this Agreement, strictly enforce any material
        rights, warranties, licenses and other benefits accruing to it under
        each of its agreements with third parties whose goods or services are
        utilized in the providing of the Services.

6.11    AD represents, warrants, covenants and agrees that the hardware,
        software, firmware and intellectual property provided, developed and/or
        used by AD hereunder shall not infringe upon or violate any patent,
        copyright, trademark, trade secret or other intellectual property right
        of any third party.

6.12    AD represents, warrants, covenants and agrees that the Services shall be
        furnished and in all respects provided in conformance and compliance
        with applicable laws.

                                       6
<PAGE>


6.13    AD represents, warrants, covenants and agrees that the software and
        firmware utilized to provide the Services hereunder shall not incur
        errors or defects as a result of the century date change in the year
        2000.

6.14    AD hereby represents and warrants that it has the authority to enter
        into this Agreement and the right to provide the Services to PRWW
        hereunder without breach of any obligation to AOL or any third party,
        and that its performance under this Agreement will not breach any
        obligation to AOL or any third party, or any contract, agreement, rule,
        law or regulation of whatsoever nature.

      7. ASSIGNMENT

        Neither party shall assign any of its rights nor delegate any of its
        obligations under this Agreement without the prior written consent of
        the other party; provided that the rights and obligations of a party
        under this Agreement will be automatically assigned to and assumed by
        any successor to it by merger or consolidation or any person which
        acquires substantially all of the assets and business of such person.
        Any prohibited assignment or delegation shall be null and void.

      8. RELATIONSHIP OF THE PARTIES

        The parties are independent contractors. Nothing in this Agreement or in
        the activities contemplated by the parties pursuant to this Agreement
        shall be deemed to create an agency, partnership, employment or joint
        venture relationship between the parties. Each party shall be deemed to
        be acting solely on its own behalf and, except as expressly stated, has
        no authority to pledge the credit of, or incur obligations or perform
        any acts or make any statements on behalf of, the other party. Neither
        party shall represent to any person or permit any person to act upon the
        belief that it has any such authority from the other party. Neither
        party's officers or employees, agents or contractors shall be deemed
        officers, employees, agents or contractors of the other party for any
        purpose.

      9. AMENDMENT

        No changes, amendments or modifications of any of the terms or
        conditions of this Agreement shall be valid unless made by an instrument
        in writing signed by both parties.

                                       7

<PAGE>

    10. COMPLIANCE WITH LAWS

        The parties shall comply with all applicable international, federal,
        state and local laws, regulations and ordinances as they relate to this
        Agreement, including but not limited to, the regulations of the United
        States Government, which are incorporated in this Agreement by this
        reference as if set forth in full.

    11. MISCELLANEOUS

        11.1  Whenever this Agreement requires either party's approval, consent
              or satisfaction, the response shall not be unreasonably or
              arbitrarily withheld or delayed.

        11.2  Section headings are included for convenience only and are not to
              be used to construe or interpret this Agreement.

        11.3  No delay, failure or waiver of either party's exercise or partial
              exercise of any right or remedy under this Agreement shall operate
              to limit, impair, preclude, cancel, waive or otherwise affect such
              right or remedy.

        11.4  If any provision of this Agreement is held invalid, illegal or
              unenforceable, the validity, legality or unenforceability of the
              remaining provisions shall in no way be affected or impaired
              thereby.

        11.5  This Agreement may be executed by the parties in one or more
              counterparts, each of which when so executed shall be an original,
              but all such counterparts shall constitute one and the same
              instrument.

        11.6  This Agreement is entered into and shall be governed by the
              internal laws and not the -laws regarding conflicts of laws of the
              State of Maryland.

        11.7  The remedies under this Agreement shall be cumulative and not
              exclusive, and the election of one remedy shall not preclude
              pursuit of other remedies. Either party may seek any remedy
              generally available under the governing law.

        11.8  The parties each warrant, represent, covenant and agree that they
              will not assign to perform any efforts under this Agreement any
              individual who is an unauthorized alien under the Immigration
              Reform and Control Act of 1986 or its implementing regulations.
              Each party shall indemnify and hold harmless the other party and
              its respective Associates from and against any and all
              liabilities, damages, losses, claims or expenses (including
              attorneys' fees) arising out of any breach by such party of this
              Section. In the event any AD personnel or contractor working under
              this Agreement, or other individual(s) providing

                                       8
<PAGE>

              Services to PRWW on behalf of AD under this Agreement, are
              discovered to be unauthorized aliens, AD will irnmediately remove
              such individuals from performing work and replace such individuals
              with individuals who are not unauthorized aliens. In the event any
              PRWW personnel or contractor working under this Agreement or other
              individual(s) providing Services to AD on behalf of PRWW under
              this Agreement, are discovered to be unauthorized aliens, PRWW
              will immediately remove such individuals from performing work and
              replace such individuals with individuals who are not unauthorized
              aliens.

         11.9 If either party's performance under this Agreement is interfered
              with by reason of any circumstances beyond said party's reasonable
              control, including without limitation, severe weather, fire,
              explosion, A.C. power failure, acts of God, war, revolution, civil
              commotion, or acts of public enemies, any law, order, regulation,
              ordinance or requirement of any government or legal body or any
              representative of any such government or legal body, labor unrest,
              including without limitation, strikes, slow downs, picketing or
              boycotts, then said party shall be excused from its performance on
              a day-for-day basis to the extent of such interference.

        11.10 Notices and other communications; shall be transmitted in writing
              by certified U.S. Mail, postage prepaid, return receipt requested,
              or by facsimile or by overnight courier, addressed to the parties
              at the address first set forth above. Such notices and
              communications shall be deemed effective four (4) days after the
              date of mailing or upon receipt as evidenced by the U.S. Postal
              Service return receipt cards, whichever is earlier, or upon
              receipt if sent by facsimile or overnight courier.

    12. ENTIRE AGREEMENT

              This Agreement, with any other instrument, agreement or document
              attached or referred to, which are incorporated by this reference
              as though set forth in full, embodies the final, full and
              exclusive statement of the agreement between AD and PRWW, and as
              of its date supersedes all prior agreements, negotiations,
              representations and proposals, written or oral, relating to the
              Services. This Agreement shall not be construed to govern any
              other transaction between AD and PRWW. Neither party shall be
              bound or liable to any other party for any representation, promise
              or inducement made by any agent or person in their employ relating
              to the subject matter which is not embodied in this Agreement.

                                       9
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.23
<SEQUENCE>5
<DESCRIPTION>EXHIBIT 10.23
<TEXT>


<PAGE>
                               SUBLEASE AGREEMENT

THIS SUBLEASE AGREEMENT ("Sublease") is entered into as of June, 1998 by and
between Sublandlord and Subtenant, each as defined below in Section A.

     A. THE PARTIES

     Sublandlord's Name and          Raytheon Engineers & Constructors, Inc.
     type of entity:                 a Delaware Corporation

     Sublandlord's Address           30 South 17th Street
     for Notices:                    Philadelphia, PA 19103
                                     ATT: Real Estate Operations Manager

     Sublandlord's Payment           Raytheon Engineers & Constructors, Inc.
     Address:                        P.O. Box 8500 - S5450
                                     Philadelphia, PA 19178

     Subtenant's Name and            Premier Research Worldwide, Ltd.
     type of entity:                 a Delaware Corporation

     Subtenant's Address             124 South 15th Street
     for Notices prior to            Philadelphia, PA 19102-3010
     Commencement Date:              ATT: Fred M. Powell

     Subtenant's Address             30 South 17th Street
     for Notices after               Philadelphia, PA 19103
     Commencement Date:              ATT: Fred M. Powell

     Prime Landlord's Name           Takaji Kobayashi and Takeshi Shiratori, as
     and type on entity              trustees of Shuwa Trust of Philadelphia, a
                                     Pennsylvania Business Trust

     Prime Landlord's address        c/o Shuwa Corporation of New York
     for Notices                     1330 Avenue of the Americas
                                     New York, N.Y. 10019
<PAGE>

     B. DEFINITIONS AND BASIC TERMS

        The following definitions and basic terms shall have the indicated
meanings when used in this Lease:

     0.1 Building:                   The building located on the land
                                     bounded by Ludlow Street, 17th Street,
                                     Ranstead Street and 18th Street,
                                     Philadelphia, Pennsylvania.

     0.2 Demised Premises:           Entire 8th and 9th floors of Building

     0.3 Property:                   The Building, the parcel of land upon
                                     which the Building is situated and any
                                     other improvements located thereon.

     0.4 Subtenant's Rentable        58,156 rentable square feet
         Square Feet:

     0.5 Total Rentable Square
         Feet in the Building:       587,637 rentable square feet

     0.6 Subtenant's Proportionate
         Share:                      9.9% which is the percentage
                                     obtained by dividing (i)
                                     Subtenant's Rentable Square
                                     Feet by (ii) the total Rentable
                                     Square Feet in the Building.

     0.7 Commencement Date:          The Commencement Date is defined in
                                     Section 2.1.

     0.8 Term:                       Commencing on the Commencement
                                     Date and ending at 5:00 PM on August
                                     30, 2005 subject to adjustment and
                                     earlier termination as provided in the
                                     Prime Lease.

                                      -2-
<PAGE>

     0.9 Base Rent:

                               BASE RATE SCHEDULE
                               ------------------
================================================================================
   
                     Base Rent/               Annual                 Monthly
     Year              Sq Foot              Base Rent               Base Rent
--------------------------------------------------------------------------------
1st Lease year         $13.00               $756,028               $63,002.33
commencing with
Commencement Date
--------------------------------------------------------------------------------
2nd lease year         $15.00               $872,340               $72,695.00
--------------------------------------------------------------------------------
3rd lease year         $18.00             $1,046,808               $87,234.00
--------------------------------------------------------------------------------
4th lease year until   $18.25             $1,061,347               $88,445.58
lease expiration
================================================================================

     0.10 Additional Rent:         Additional Rent is defined in Section
                                   3.2.

     0.11 Rental:                  Base Rent, Additional Rent and all other
                                   sums that Subtenant may owe to
                                   Sublandlord under this Sublease.

     0.12 Security Deposit:        See Section 4.

     0.13 Expense Stop/
          Base Year:               Base Year: 1998

     0.14 Tax Stop/
          Base Year:               Base Year: 1998

     0.15 Permitted Use:           General office use and no other (See
                                   Section 6 for further clarification).
     0.16 Tenant Improvement
          Allowance:               See Section 17.

     0.17 Option to Renew          None.

     0.18 Option to Terminate      None.

     0.19 Option to Expand         None


                                       -3-
<PAGE>

                             PRELIMINARY STATEMENT
                             ---------------------

             Whereas, a Lease Agreement was entered into on June 13, 1973,
between Paul F. Hellmuth, Gorden E. Emerson, Jr., Robert C. Elder and John M.
Hines as Trustees for Middle City Trust, as landlord (hereinafter called "Prime
Landlord," including any successors and assigns), and Sublandlord, as tenant,
for a portion of rentable floor area, consisting of 393,014 square feet, in the
building known as 30 South 17th Street, Philadelphia, Pennsylvania (hereinafter
called the "Building"). The Building is set on a parcel of land in Philadelphia
bounded by Ludlow Street, 17th Street, Ranstead Street and 18th Street
(hereinafter called the "Property"). The Property is more fully described in the
Prime Lease.

             Whereas, the Lease Agreement has been amended by written amendments
dated October 22, 1973; April 9, 1974; July 18, 1974; November 12, 1974; January
10, 1975; May 5, 1976; April 17, 1979; December 19, 1983; February 9, 1984 and
October 25, 1994. The aforesaid Lease Agreement of June 13, 1973, and the
amendments thereto are hereinafter referred to as the "Prime Lease," a true (but
expurgated as to financial terms) copy of which has been delivered to the
Subtenant, and Subtenant hereby acknowledges receipt of same.

             Whereas, Subtenant desires to sublet from Sublandlord a portion of
the premises covered by the Prime Lease, for the term, the rent and upon and
subject to the covenants, agreements, terms, conditions, limitations, exceptions
and reservations herein contained.

             NOW, THEREFORE, in consideration of the premises and mutual
covenants contained herein, the parties hereto for themselves, their successors
and assigns, hereby covenant and agree as follows:

             1. Subleasing of Demised Premises.

                1.1 Sublandlord hereby subleases to Subtenant, and Subtenant
hereby hires from Sublandlord the entire 8th and 9th floors of the Building
(which spaces are herein called the "Demised Premises"). For purposes of this
Sublease, the Demised Premises shall be deemed to contain 58,156 rentable
square feet.

                1.2 Sublandlord shall make available to Subtenant four (4)
unreserved parking passes in the Building Parking Garage. Subtenant shall be
responsible to pay the monthly fee associated with the use of the parking
passes.

             2. Term.


                                       -4-
<PAGE>

                2.1 Demised Term. The term ("Demised Term") of this Sublease
shall, commence on the earlier of (i) the date on which Subtenant, with
Sublandlord's approval, shall take possession of the Demised Premises for the
operation of its business therefrom, or (ii) November 1, 1998. The dates for the
commencement and expiration of the Demised Term are referred to in this
Sublease as the "Commencement Date" and the "Expiration Date", respectively.

                2.2 Confirmation of Commencement Date. When a Commencement Date
has been established in accordance with subparagraph 2.1 hereof, Sublandlord and
Subtenant shall, at the request of either, execute an instrument in form
reasonably satisfactory to Sublandlord setting forth said Commencement Date.

                2.3 Recordation. This Sublease shall not be filed for record
with the recorder's office of the county in which the Demised Premises are
located.

                2.4 Notwithstanding the generality of the foregoing, in the
event that Sublandlord has not made the Premises available to Subtenant on or
before June 10, 1998 for Tenant to begin its Tenant Improvements (the "Outside
Date") for any reason other than Prime Landlord's failure to grant its consent
to this Sublease, then Subtenant shall thereafter have the option to terminate
this Sublease by written notice delivered to Sublandlord at any time prior to
the date that Sublandlord so makes the Premises available to Subtenant; and, in
the event Subtenant timely delivers such notice (time being of the essence),
this Sublease shall be deemed null and void, and Sublandlord shall thereupon
promptly return all prepaid rent and security to Subtenant whereupon all further
obligations of the parties hereto shall end.

             3. Base Rent, Additional Rent and Escalation.

                3.1 Subtenant shall pay to Sublandlord, commencing on the
Commencement Date, in currency which at the time of payment is legal tender for
public and private debts in the United States of America, the Base Rent, except
that the first full monthly installment due under this Sublease is being paid on
the signing of this Sublease. The Base Rent shall be payable in advance in
monthly payments on the first day of each month in accordance with Base Rent
Schedule set forth in Section B. 0.9., provided that the Base Rent shall be paid
on a pro-rata basis for any partial month at the beginning or end of the Term.
The Base Rent shall include all services called for in the Prime Lease such as
janitorial, security, HVAC and normal electricity for normal business operations
provided that Subtenant shall pay for any increases in the cost of such services
as provided in Section 3.2 below. If the Prime Landlord has the right to impose
additional charges with respect to the Demised Premises pursuant to Exhibit D,
Item VI of the Prime Lease, such electrical needs will be separately metered and
paid for by Subtenant. Except as may be otherwise expressly provided for herein,
Base Rent and all other amounts payable by Subtenant to Sublandlord under the
provisions of this Sublease shall be paid promptly when due, without notice or
demand therefor,

                                      -5-
<PAGE>

and without deduction, abatement, counter-claim or set-off of any amount or for
any reason whatsoever. Base Rent and additional charges shall be paid to
Sublandlord at the address of Sublandlord set forth in the preamble of this
Sublease or to such other person and/or at such other address as Sublandlord may
from time to time designate by notice to Subtenant. No payment by Subtenant or
receipt by Sublandlord of any lesser amount than the amount stipulated to be
paid hereunder shall be deemed other than on account of the stipulated Base Rent
or additional charges; nor shall any endorsement or statement on any check or
letter be deemed an accord and satisfaction, and Sublandlord may accept any
check or payment without prejudice to Sublandlord's right to recover the balance
due or to pursue any other remedy available to Sublandlord.

                3.2 In addition to its obligation to pay Base Rent, Subtenant
shall pay Subtenant's Proportionate Share of increases over the Base Year (as
defined below) in the Real Estate Tax Payment and Operating Expenses (as such
terms are defined or used in the Prime Lease) payable by Sublandlord with
respect to the Demised Premises ("Additional Rent") pursuant to the Prime Lease
except that for the purposes of this Agreement the Base Tax Year and the Base
Expense Year shall be calendar year 1998.

                3.3 The sums for which Subtenant shall be liable pursuant to
subparagraph 3.3 above shall be deemed additional rent and shall be payable by
Subtenant to Sublandlord within thirty (30) days of the billing date. Such
billing shall be accompanied by copies of such bills as Sublessor shall have
received from Prime Landlord relating to such charges, and such supporting
documents and data as Prime Landlord shall have provided Sublandlord.

                     3.3.1 At any time during each Lease Year (which shall be a
calendar year unless otherwise defined in the Prime Lease), Sublandlord may
furnish to Subtenant a written statement or statements (an "Estimate
Statements") setting forth Sublandlord's reasonable estimate of the Operating
Expense Payment for such Lease Year (the "Estimated Payment"). Provided that an
Estimate Statement has been delivered to Subtenant fifteen (15) days prior to
such date, Subtenant shall pay to Sublandlord on the first day of each month an
amount equal to one-twelfth (1/12th) of the Estimated Payment for such Lease
Year. If Sublandlord furnishes an Estimate Statement for a Lease Year subsequent
to the commencement thereof, then (i) until the first day of the month following
the month in which the Estimate Statement is furnished to Subtenant, Subtenant
shall continue to pay to Sublandlord on the first day of each month an amount
equal to the monthly sum payable by Subtenant to Sublandlord with respect to the
next previous Lease Year; (ii) promptly after the Estimate Statement is
furnished to Subtenant, Sublandlord shall give notice to Subtenant stating
whether the amount previously paid by Subtenant to Sublandlord for the current
Lease Year was greater or less than the installments of the Estimated Payment to
be paid for the current Lease Year, and (a) if there shall be a deficiency,
Subtenant shall pay the amount

                                      -6-
<PAGE>

thereof within fifteen (15) days after demand therefor, or (b) if there shall
have been an overpayment, Sublandlord shall credit against the next installments
of the Base Rent and payments of Additional Rent payable under this Sublease,
the amount of Subtenant's overpayment (or in the event that no additional Base
Rent is due Sublandlord shall pay said overpayment directly to Subtenant; and
(iii) on the first day of the month following the month in which the Estimate
Statement is furnished to Subtenant, and monthly thereafter throughout the
remainder of the Lease Year, Subtenant shall pay to Sublandlord an amount equal
to one-twelfth (1/12th) of the Operating Expense Payment shown on the Estimate
Statement. Any amount owing to Subtenant subsequent to the expiration or earlier
termination of the Term shall be paid to Subtenant within fifteen (115) business
days after a final determination has been made of the amount due to Subtenant.
Subtenant's obligation for the Operating Expense Payment shall commence as of
the Commencement Date. The Operating Expense Payment shall be prorated for any
partial Lease Years in which the Commencement Date shall occur and the Term
shall end.

                     3.3.2 Subtenant shall pay to Sublandlord any amounts owed
with respect to Real Estate Taxes pursuant to Section 3.2 above when Sublandlord
is required to pay such Real Estate Taxes to the Prime Landlord pursuant to
Section 2.6 of the Prime Lease. Subtenant's obligation for Real Estate Taxes
shall commence as of the Commencement Date. The Real Estate Tax Payment shall be
prorated for any partial Lease Years in which the Commencement Date shall occur
and the Term shall end.

                     3.3.3 Within 15 days after receipt from Prime Landlord,
Sublandlord shall furnish to Subtenant an annual statement or statements (the
"Annual Statements ") setting forth the items constituting the Operating
Expenses and/or Real Estate Taxes during such Lease Year, which Annual
Statements shall be prepared based upon and accompanied by the statement of
Operating Expenses and/or Real Estate Taxes received by Sublandlord from Prime
Landlord. If the Annual Statements shows that the Operating Expense Payment (or
other payments) for such Lease Year exceeded the Operating Expense Payment which
should have been paid for such Lease Year, Sublandlord shall credit against the
next installments of Base Rent and payments of Additional Rent payable under
this Sublease, the amount of such excess; if the Annual Statement for such Lease
Year shows that the Estimated Operating Expense Payment for such Lease Year was
less than the Operating Expense Payment (or other payments) which should have
been paid for such Lease Year, Subtenant shall pay the amount of such deficiency
within fifteen (15) days after receipt of the Annual Statement. Any amount
owing to Subtenant subsequent to the expiration or earlier termination of the
Term shall be paid to Subtenant within fifteen (15) days after delivery of the
final Annual Statement.

                     3.3.4 Each Annual Statement shall be conclusive and binding
upon Subtenant unless, within six (6) months after receipt thereof, Subtenant
shall

                                      -7-
<PAGE>

notify Sublandlord that it disputes the correctness of the Annual Statement,
specifying in reasonable detail based on the information available to Subtenant
the manner in which the Annual Statement is claimed to be incorrect. If such
notice is sent, provided Subtenant shall pay to Sublandlord the amount shown to
be due to Sublandlord on the disputed Annual Statement, Sublandlord agrees to
use reasonable efforts to enforce its rights under the Lease to dispute the
correctness of the statements of Operating Expense and/or the Real Estate Taxes
delivered by Prime Landlord to Sublandlord the cost of which dispute shall be
equitably apportioned among Subtenant and such other subtenants of Sublandlord
at the Building who also request that Sublandlord dispute such statements.
Subtenant agrees to indemnify and hold Sublandlord harmless from and against any
and all claims, costs, expenses and liabilities in connection therewith,
including, without limitation, reasonable attorneys fees and disbursements. If
Prime Landlord shall revise the statements of Operating Expense Payment and/or
Real Estate Taxes disputed by Subtenant, Sublandlord shall deliver to Subtenant
a revised Annual Statement, and an appropriate payment or credit by Sublandlord,
or payment by Subtenant, as the case may be.

                3.4 Anything to the contrary notwithstanding, if Subtenant shall
procure any additional services for the Demised Premises (such as those
contemplated by Section 4.1.2 of the Prime Lease) from Prime Landlord, Subtenant
shall pay for same at the rates charged therefor by Prime Landlord and shall
make such payment at the same time it pays the Base Rent to Prime Landlord or
Sublandlord as Sublandlord shall direct unless differently directed by the Prime
Landlord. Any sums payable pursuant to this subsection shall be deemed
Additional Rent and shall be collectible as such.

                3.5 All Base Rent, Additional Rent and all other costs, charges
and sums payable by Subtenant hereunder (collectively, "Rental"), shall
constitute rent under this Sublease, and shall be payable to Sublandlord at its
address as set forth herein, unless Sublandlord shall otherwise so direct in
writing (or unless otherwise directed to the extent permitted by Section 3.4 by
the Prime Landlord.

                3.6 If Subtenant shall fail to pay within ten (10) days after
due any installment of Rental, Subtenant shall pay to Sublandlord, in addition
to such installment of Rental, as a late charge and as Additional Rent, a sum
equal to interest at the Applicable Rate (hereinafter defined) per annum on the
amount unpaid, commencing from the date such payment was due to and including
the date of payment. The "Applicable Rate" shall be the rate equal to the lesser
of (a) two (2) percentage points above the then current rate publicly announced
by Citibank, N.A. or its successor as its "base rate" (or such other term as may
be used by Citibank, N.A. from time to time for the rate presently referred to
as its "base rate") or (b) the maximum rate permitted by applicable law.

                3.7 Subtenant shall promptly pay the Rental as and when the same
shall become due and payable without set-off, offset or deduction of any kind



                                      -8-
<PAGE>

whatsoever, except as expressly set forth herein, and, in the event of
Subtenant's failure to pay the same when due (subject to grace periods provided
herein), Sublandlord shall have all of the rights and remedies provided for
herein or at law or in equity, in the case of non-payment of rent. Upon the
request of Subtenant, Sublandlord shall reasonably consider taking action under
Section 8.8.2 of the Prime Lease provided that Subtenant shall, in addition to
any other indemnity provided for herein, fully indemnify and hold Sublandlord
harmless from any and all cost and expenses incurred by Sublandlord (including
reasonable attorney fees) in complying with Subtenant's request.

                3.8 Sublandlord's failure during the Term to prepare and deliver
any statements or bills required to be delivered to Subtenant hereunder, or
Sublandlord's failure to make a demand under this Article 3 or under any other
provisions of this Sublease shall not in any way be deemed to be a waiver of, or
cause Sublandlord to forfeit or surrender its rights to collect any Rental which
may have become due pursuant to this Article 3 during the Term. Subtenant's
liability for Rentals due under this Article 3 accruing during the Term shall
survive the expiration or sooner termination of this Sublease.

                3.9 Subtenant shall pay to Sublandlord, upon the execution of
this Sublease, the amount of Sixty Three Thousand Two Dollars and thirty three
cents ($63,002.33) representing a prepayment of the first month's rental due
under this Sublease.

             4. SECURITY DEPOSIT.

                4.1 On the date of execution of this Sublease by Subtenant,
Subtenant shall deposit with Sublandlord, as security for Subtenant's
obligations under this Sublease, a Letter of Credit (as hereinafter defined) or
equivalent credit instrument (the "Equivalent Credit Instrument," and,
collectively with Letter of Credit, the "Security Instrument") such as a
certificate of deposit issued in the name of the Sublandlord, in the amount of
Six Hundred Thousand Dollars ($600,000.00) (the "Security"). In the event that
Subtenant seeks to use an Equivalent Credit Instrument as security, such
Equivalent Credit Instrument shall (1) be issued by a bank acceptable to
Sublandlord in its sole discretion, (2) shall have a liquidity that is cash
equivalent as determined by Sublandlord in its sole discretion, and (3) at all
times be in the possession of Sublandlord. Sublandlord shall have the right to
draw upon such Security Instrument any number of times up to the aggregate
amount equal to the face value of such of Security Instrument following a
default by Subtenant beyond notice and any applicable cure period. In the event
that Subtenant shall fully and faithfully comply with all of the terms,
provisions, covenants and conditions of the Sublease, the Security Instrument
shall be returned to Subtenant promptly after the date fixed as the end of the
Term and delivery of the entire possession of the Premises to Sublandlord in the
condition required pursuant to the Sublease. In the event Sublandlord applies or
retains any

                                      -9-
<PAGE>

portion or all of the Security Instrument deposited, Subtenant shall, within ten
(10) days following written demand therefor, pay to Sublandlord, with interest,
the amount so applied. Subtenant's failure to so pay such amount shall be deemed
a default by Subtenant in the payment of any installment of Base Rent.

                4.2 The Letter of Credit shall be a clean, irrevocable, letter
of credit ("Letter of Credit") issued by any bank which is a member of
Philadelphia Clearing House Association (hereinafter referred to as the "Issuing
Bank"), which Letter of Credit shall have a term of not less than one (1) year,
be issued for the benefit of Sublandlord, be in the amount of the Security
during the period commencing on the date of such Letter of Credit as deposited
with Sublandlord and continuing through the Expiration Date. The Issuing Bank
shall pay to Sublandlord or its duly authorized representative in one
installment or in several partial installments an amount up to the face value of
the Letter of Credit upon presentment of the Letter of Credit and a sight draft
in the amount to be drawn and a letter signed by Sublandlord stating that
Sublandlord is entitled to draw upon the Letter of Credit in the amount
requested based on a default by Subtenant under the Sublease and, that any
applicable notice and cure period has expired. Subtenant shall provide a
replacement Letter of Credit no later than thirty (30) days prior to the
expiration of the then existing Letter of Credit. A failure by Subtenant to
provide a replacement Letter of Credit within the aforesaid period shall entitle
Sublandlord to draw the face amount under the then existing Letter of Credit and
shall constitute a default hereunder beyond any applicable cure period.

                4.3 Any proceeds drawn by Sublandlord under a Security
Instrument shall be held by Sublandlord, to the extent that such proceeds are
not applied to the satisfaction of any of Subtenant's obligations under this
Sublease, as if the same were a cash security deposit.

                4.4 Notwithstanding the foregoing, in the event that Subtenant
is not then in default of any term, condition or covenant of this Sublease, then
the Security may be periodically reduced beginning with the Commencement Date on
a straight line basis provided that the Security shall not be reduced to less
than Sixty Three Thousand Nine Hundred Ninety Two Dollars and thirty three cents
($63,992.33) at the expiration of the Term. Provided that Subtenant is not in
default under any of the terms or conditions of this Sublease, the balance of
the Security Instrument shall be released or returned to Subtenant within thirty
days after the expiration of the Term. All interest earned on the Certificate of
Deposit accrues to the benefit of the Subtenant.

             5. Subordination to and Incorporation of the Lease.

                5.1 This Sublease is in all respects subject and subordinate to
the terms and conditions of the Prime Lease (true and complete copies of which
have been furnished by Sublandlord to Subtenant), and to all matters to which
the Prime Lease are subject and subordinate. Subtenant shall indemnify
Sublandlord for, and shall hold it harmless from and against, any and all
losses, damages, penalties, liabilities, costs and

                                      -10-
<PAGE>

expenses, including, without limitation, reasonable attorneys' fees and
disbursements, which may be sustained or incurred by Sublandlord by reason of
Subtenant's failure to keep, observe or perform any of the terms, provisions,
covenants, conditions and obligations on Sublandlord's part to be kept, observed
or performed under the Prime Lease with respect to the Demised Premises to the
extent same shall have been incorporated herein, or otherwise arising out of or
with respect to Subtenant's use and occupancy of the Demised Premises from and
after the Commencement Date. Sublandlord shall promptly provide Subtenant with a
copy of any notice it receives from Prime Landlord with respect to any alleged
breach and the same opportunity permitted by the Prime Lease to cure such breach
provided that the time to cure shall in no event extend beyond the date that
Sublandlord must effectuate any cure. Sublandlord shall indemnify Subtenant for,
and shall hold it harmless from and against, any and all losses, damages,
penalties, liabilities, costs and expenses, including, without limitation,
reasonable attorneys fees and disbursements, which may be sustained or incurred
by Subtenant by reason of Sublandlord's failure to keep, observe or perform any
of the terms, provisions, covenants, conditions and obligations on Sublandlord's
part to be kept, observed or performed under the Prime Lease.

                5.2 Except as otherwise expressly provided in, or otherwise
inconsistent with, this Sublease, or to the extent not applicable to the
Demised Premises, the terms, provisions, covenants, stipulations, conditions,
rights, obligations, remedies and agreements contained in the Prime Lease
including but not limited to Sections 2.2 (first sentence only), 2.7 (as amended
by the Seventh and Eighth Lease Amendments), 2.8, 2.9, 3.3, 3.4 (first
paragraph), 3.6, 4.1.1, 4.1.2, 4.1.3, 4.1.5, 4.1.6, 4.1.7, 4.2, Article 5,
Article 6, Article 7, Article 8, Article 9 and Section 1 of the Ninth Lease
Amendment and Sections 6(e) and 6(f) of the Tenth Lease Amendment are
incorporated in this Sublease by reference, and are made a part hereof as if
herein set forth at length, Sublandlord being substituted for the "Landlord"
under the Prime Lease, Subtenant being substituted for the "Tenant" under the
Prime Lease, and Demised Premises being substituted for "Premises" under the
Prime Sublease except that the following provisions of the Lease shall be deemed
deleted therefrom and shall have no force and effect as between Sublandlord and
Subtenant: Article 1, Sections 2.1, 2.2 (except for the first grammatical
paragraph), 2.4, 2.5, 2.6, 2.10, 3.1, 3.2, 3.4 (second paragraph), 3.6, 4.1.4.
5.6, 5.7 (except that with respect to Sections 5.6 & 5.7 Subtenant shall have
all of the obligations to the Prime Landlord set forth therein) and Sections 3,
4 and 5 of the Tenth Amendment.

             6. Use: Quiet Enjoyment

                6.1 Subtenant shall use and occupy the Demised Premises for
general office use and for no other purpose provided that general office use
shall include a clinical testing laboratory but in no event shall any outpatient
or inpatient testing, treatment or services be permitted nor shall animal
testing or research be permitted.

                                      -11-
<PAGE>

                6.2 Subtenant shall not permit the occupancy of any space in the
Building or Demised Premises for a use causing an unusually high degree of
traffic through or abuse of the lobby, elevators or common use areas in excess
of normal use for a first-class office building, or causing unusual
concentration of persons in the lobby, elevators or common areas, or resulting
in commotion, noise or generally disagreeable activities or conditions, or
employing or engaged in activities which result in a denser use of space than
customary in office buildings of the contemplated character of the Building
provided that a clinical testing laboratory shall not be deemed a generally
disagreeable activity.

                6.3 As long as Subtenant shall pay the Rental due hereunder and
shall duly perform all the terms, covenants and conditions of this Sublease on
its part to be performed and observed, Subtenant shall peaceably and quietly
have, hold and enjoy the Demised Premises during the Term hereof, subject to
the provisions of this Sublease.

                6.4 Sublandlord will not restrict Subtenant's access to the
Demised Premises on a 24 hour seven day a week basis provided that nothing
herein shall affect the rights of the Prime Landlord under the Prime Lease.

             7. Covenants with Respect to the Lease.

                7.1 Subtenant shall not do anything that would constitute a
default under the Prime Lease or omit to do anything that Subtenant is obligated
to do under the terms of this Sublease so as to cause there to be a default
under the Prime Lease.

                7.2 The time limits set forth in the Prime Lease for the giving
of notices, making demands, performance of any act, condition or covenant, or
the exercise of any right, remedy or option, are changed for the purpose of this
Sublease, by lengthening or shortening the same in each instance, as
appropriate, so that notices may be given, demands made, or any act, condition
or covenant performed, or any right, remedy or option hereunder exercised, by
Sublandlord or Subtenant, as the case may be (and each party covenants that it
will do so) within five (5) days prior to the expiration of the time limit,
taking into account the maximum grace period, if any, relating thereto contained
in the Prime Lease. Each party shall promptly deliver to the other party copies
of all notices, requests or demands which relate to the Demised Premises or the
use or occupancy thereof after receipt of same.

                7.3 Compliance with Laws. Subtenant shall at all times fully
comply with all applicable laws, ordinances, rules and regulations of all
governmental authorities ("Applicable Laws") with respect to its occupancy of
the Demised Premises and the operation of its business conducted therein. At
the request of Sublandlord,

                                      -12-
<PAGE>

Subtenant shall deliver copies of all permits, certificates and licenses
evidencing Subtenants compliance with all Applicable Laws.

             8. Services and Repairs.

                8.1 Notwithstanding anything to the contrary contained in this
Sublease or in the Prime Lease, Sublandlord shall not be required to provide any
of the services that Prime Landlord has agreed to provide, whether specified in
the Prime Lease or required by law, or furnish the electricity to the Demised
Premises that Prime Landlord has agreed to furnish pursuant to the Prime Lease
(or required by law), or make any of the repairs or restorations that Prime
Landlord has agreed to make pursuant to the Prime Lease (or required by law), or
comply with any laws or requirements of any governmental authorities with
respect to the Demised Premises, or take any other action that Prime Landlord
has agreed to provide, furnish, make, comply with, or take or, cause to be
provided, furnished, made, complied with or taken under the Prime Lease, but
Sublandlord agrees to use all diligent efforts as approved by Subtenant, at
Subtenant's sole cost and expense, to obtain the same from Prime Landlord
(provided, however, that Sublandlord shall not be obligated to use such efforts
or take any action which might give rise to a default under the Prime Lease),
and Subtenant shall rely upon, and look solely to, Prime Landlord for the
provision, furnishing or making thereof or compliance therewith. If Prime
Landlord shall default in the performance of any of its obligations under the
Prime Lease, including its obligation to comply with environmental and other
laws, Sublandlord shall, upon request and at the expense of Subtenant, timely
institute and diligently prosecute any action or proceedings which Subtenant, in
its reasonable judgment, deems meritorious, in order to have Prime Landlord make
such repairs, furnish such electricity, provide such services or comply with any
other obligation of Prime Landlord under the Prime Lease or as required by law.
Subtenant shall indemnify and hold harmless Sublandlord from and against any and
all such claims arising from or in connection with such request, action or
proceeding unless resulting from an negligent act or omission of Sublandlord.
This indemnity and hold harmless agreement shall include indemnity from and
against any and all liability, fines, suits, demands, costs and expenses of any
kind or nature, including, without limitation, reasonable attorneys' fees and
disbursements, incurred in connection with any such claim, action or proceeding
brought thereon. Subtenant shall not make any claim against Sublandlord for any
damage which may arise, nor shall Subtenant's obligations hereunder be
diminished, by reason of (i) the failure of Prime Landlord to keep, observe or
perform any of its obligations pursuant to the Prime Lease unless such failure
is due to Sublandlord's negligence or misconduct, or (ii) the acts or omissions
of Prime Landlord, its agents, contractors, servants, employees, invitees or
licensees. Sublandlord shall not be responsible for any failure or interruption,
for any reason whatsoever, of the services or facilities that may be appurtenant
to or supplied at the Building by the Prime Landlord or otherwise, including,
without limitation, heat, air conditioning, water, electricity, elevator service
and cleaning service, if any; and no failure to furnish, or interruption of, any
such services or facilities shall give rise to any

                                      -13-
<PAGE>

(x) abatement, diminution or reduction of Subtenant's obligations under this
Sublease, (y) constructive eviction, whether in whole or in part, or (z)
liability on the part of the Sublandlord. The provisions of this Section 8 shall
survive the expiration or earlier termination of the Term hereof.

             Notwithstanding anything herein to the contrary, if and to the
extent that Sublandlord obtains an abatement or reduction in rent under the
terms of the Prime Lease due to Prime Landlord's failure to deliver essential
services to the Premises, then Subtenant shall be entitled to a corresponding
abatement or reduction of rent under this Sublease.

             9. Consents.

                9.1 Sublandlord agrees that whenever its consent or approval is
required hereunder, or where something must be done to Sublandlord's
satisfaction, it shall not unreasonably withhold or delay such consent or
approval; provided, however, that whenever the consent or approval of Prime
Landlord or the lessor under a superior lease, or the mortgagee under a
mortgage, as the case may be, is also required pursuant to the terms of the
Prime Lease, if Prime Landlord or the lessor under a superior lease, or the
mortgagee under a mortgage shall withhold its consent or approval for any reason
whatsoever, Sublandlord shall not be deemed to be acting unreasonably if it
shall also withhold its consent or approval. However, Sublandlord shall
reasonably cooperate with Subtenant in obtaining such consent or approval. If
Prime Landlord shall withhold its consent or approval in connection with this
Sublease or the Demised Premises in any instance where, under the Prime Lease,
the consent or approval of Prime Landlord may not be unreasonably withheld,
Sublandlord, upon the request and at the expense of Subtenant, shall either (i)
timely institute and diligently prosecute any action or proceeding which
Subtenant, in its reasonable judgment, deems meritorious, in order to dispute
such action by Prime Landlord at the sole cost and expense of Subtenant, or (ii)
permit Subtenant, to the extent allowable under the Prime Lease, to institute
and prosecute such action or proceeding against Prime Landlord provided that
Subtenant shall keep Sublandlord informed of its actions and shall not take any
action which might give rise to a default under the Prime Lease.

                9.2 If Subtenant shall request Sublandlord's consent and
Sublandlord has agreed, under the terms of this Sublease, that neither its
consent nor its approval shall be unreasonably withheld, and Sublandlord shall
fail or refuse to give such consent or approval, and Subtenant shall dispute the
reasonableness of Sublandlord's refusal to give its consent or approval, such
dispute shall be finally determined by a court of competent jurisdiction. In the
event that any action or proceeding is brought to enforce any term, covenant or
condition of this Sublease on the part of Sublandlord or Subtenant, the party
ultimately prevailing in such litigation shall be entitled to costs of such
litigation and to reasonable attorneys fees to be fixed by the court in such
action or proceeding, including any appeal or appeals therefrom.


                                      -14-
<PAGE>

                10. Termination of Lease. If the Prime Lease is terminated by
Prime Landlord pursuant to the terms thereof with respect to all or any portion
of the Demised Premises prior to the Expiration Date for any reason whatsoever,
including, without limitation, by reason of casualty or condemnation, this
Sublease shall thereupon terminate with respect to any corresponding portion of
the Demised Premises, and (unless such termination of the Prime Lease shall be
as a result of Sublandlord's default thereunder or a voluntary surrender of the
Demised Premises, other than a surrender of the Demised Premises permitted
under the Prime Lease with respect to a termination of the Prime Lease by reason
of casualty to or condemnation of the Demised Premises or the Building)
Sublandlord shall not be liable to Subtenant by reason thereof. In the event of
such termination, Sublandlord shall return to Subtenant that portion of the
Rental paid in advance by Subtenant with respect to such portion of the Demised
Premises, if any, prorated as of the date of such termination together with the
Letter of Credit.

                11. Sublease, Not Assignment. Notwithstanding anything contained
herein, this Sublease shall be deemed to be a sublease of the Demised Premises
and not an assignment, in whole or in part, of Sublandlord's interest in the
Prime Lease.

                12. Damage, Destruction, Fire and Other Casualty; Condemnation.
In the event that 50% or more of the Demised Premises is destroyed by fire or
other casualty such that Subtenant cannot use the Demised Premises for a period
of at least six consecutive months then either Sublandlord or Subtenant upon
thirty days written notice shall have the right to terminate this Sublease. In
the event of said fire or other casualty, rent shall abate in proportion to the
percentage of the Demised Premises Subtenant is unable to occupy.

                13. No Waivers. Failure by Sublandlord in any instance to insist
upon the strict performance of any one or more of the obligations of Subtenant
under this Sublease, or to exercise any election herein contained, shall in no
manner be or be deemed to be a waiver by Sublandlord of any of Subtenant's
defaults or breaches hereunder or of any of Sublandlord's rights and remedies by
reason of such defaults or breaches, or a waiver or relinquishment for the
future of the requirement of strict performance of any and all of Subtenant's
obligations hereunder. Further, no payment by Subtenant or receipt by
Sublandlord of a lesser amount than the correct amount or manner of payment of
Rental due hereunder shall be deemed to be other than a payment on account, or
any letter accompanying any check or payment be deemed to effect or evidence an
accord and satisfaction, and Sublandlord may accept any checks or payments as
made without prejudice to Sublandlord's right to recover the balance or pursue
any other remedy in this Sublease or otherwise provided at law or equity.

                14. Notices. Any notice, statement, demand, consent, approval,
advance or other communication required or permitted to be given, rendered or
made by either


                                      -15-
<PAGE>

party to the other, pursuant to this Sublease or pursuant to any applicable law
or requirement of public authority (collectively, "communications") shall be in
writing and shall be deemed to have been properly given, rendered or made only
if sent by personal delivery, receipted by the party to whom addressed, or
certified mail, return receipt requested, posted in a United States post office
station in the continental United States, or by reputable overnight delivery
service, addressed to Sublandlord or Subtenant at their address first above
written. All such communications shall be deemed to have been given, rendered or
made when delivered and receipted by the party to whom addressed, in the case of
personal delivery, or three (3) business days after the day so mailed or one (1)
business day after overnight delivery service. Either party may, by notice as
aforesaid, designate a different address or addresses for communications
intended for it.

                15. Broker. Each party hereto covenants, warrants and represents
to the other party that it has had no dealings, conversations or negotiations
with any broker other than Cushman & Wakefield and Preferred Real Estate
Advisors, Inc. (the "Brokers") concerning the execution and delivery of this
Sublease. Each party hereto agrees to indemnify and hold harmless the other
party against and from any claims for any brokerage commissions and all costs,
expenses and liabilities in connection therewith, including, without limitation,
reasonable attorneys' fees and disbursements, arising out of its respective
representations and warranties contained in this Section 15 being untrue.
Sublandlord shall pay any brokerage commissions due to the Brokers pursuant to a
separate agreement between Sublandlord and the Brokers. The provisions of this
Section 15 shall survive the expiration or earlier termination of the Term
hereof.

                16. Renovation of the Demised Premises.

                    16.1 Subtenant Finish Architect/Subtenant Finish
Contractor.

                          16.1.1 Subtenant shall retain the services of a
qualified and experienced Subtenant finish architect (the "Subtenant Finish
Architect") and other consultants as shall be reasonably necessary for the
purposes of planning, designing and administering the design and construction of
the Demised Premises for Subtenant occupancy. The Subtenant Finish Architect
shall be responsible for the development, completion and submission of certain
design and construction documentation for Subtenant's, Sublandlord's and Prime
Landlord's review and approval as set forth herein.

                          16.1.2 Subtenant shall retain the services of a
qualified and experienced Subtenant finish general contractor (the "Subtenant
Finish Contractor") and such other specialty contractors as shall be reasonably
necessary for the purpose of constructing Subtenant finish work. The selection
of the Subtenant Finish Contractor

                                      -16-
<PAGE>

by Subtenant shall be subject to the approval of Sublandlord, which approval
shall not be unreasonably withheld or delayed.

                    16.2 Determination of Subtenant's Space Requirement Program.
Subtenant Finish Architect shall determine Subtenant's Space Requirement
Program.

                         16.2.1 Based upon the requirements of Subtenant's Space
Requirement Program, the Subtenant Finish Architect shall develop and submit to
Subtenant and Sublandlord "Subtenant's Test Fit Plan", which shall generally
indicate the functional and organizational relationships of the Demised
Premises, the location and size of said Demised Premises, all demising
partitions, interior walls and doors, the location and configuration of office
areas, the layout of typical furniture and other special conditions and
requirements of Subtenant's space.

                         16.2.2 Upon completion of Subtenant's Test Fit Plan,
the Subtenant Finish Architect shall deliver copies of the completed Subtenant's
Test Fit Plan to Subtenant and two (2) copies to Sublandlord. Sublandlord shall
have one week to approve or reject Subtenant's Test Fit Plan.

                    16.3 Preparation and Approval of Subtenant Construction
Documents.

                         16.3.1 Subtenant shall authorize the preparation of
Subtenant Construction Documents which documents shall be completed and
delivered to Sublandlord. The Subtenant Construction Documents shall consist of
one set of architectural drawings signed and sealed by a registered Pennsylvania
architect. In addition, one set of signed and sealed engineered mechanical,
electrical and plumbing drawings will be required if necessary. Sublandlord
shall review and approve or reject the Subtenant Construction Documents within
one week of submission to Sublandlord.

                         16.3.2 Neither review nor approval by Sublandlord of
any of the Subtenant Construction Documents shall constitute a representation or
warranty by Sublandlord that such Subtenant Construction Documents either (i)
are complete or suitable for their intended purpose or (ii) comply with
applicable laws, ordinances, codes and regulations, it being expressly agreed by
Subtenant that Sublandlord assumes no responsibility or liability whatsoever to
Subtenant or to any other person or entity for such completeness, suitability or
compliance.

                    16.4 Construction of Subtenant Finish Work. Immediately
following the approval of Subtenant Construction Documents Subtenant shall cause
the Demised Premises to be improved and completed, in a good and workmanlike
manner and in accordance with Subtenant Construction Documents and in accordance
with all applicable laws.


                                      -17-
<PAGE>

                    16.5 Except as expressly set forth in this Agreement,
Subtenant acknowledges and agrees that Sublandlord has not made, does not make
and specifically negates and disclaims any representations, warranties,
promises, covenants, agreements or guaranties of any kind or character
whatsoever, whether express or implied, oral or written, past, present or
future, of, as to, concerning or with respect to: (a) the nature, quality or
condition of the Demised Premises, (b) the suitability of the Demised Premises
for any and all activities and uses which Subtenant may conduct thereon, (d) the
compliance of or by the Demised Premises or its operation with any laws, rules,
ordinances or regulations of any applicable governmental authority or body, (e)
the manner or quality of the construction or materials, if any, incorporated
into the Demised Premises, (f) the manner, quality, state of repair or lack of
repair of the Demised Premises, or (h) compliance with any Environmental Laws or
any pollution or land use laws, rules, regulations, orders or requirements,
including the existence in or on the Demised Premises of Hazardous Materials,
(i) any other matter with respect to the Demised Premises. Additionally, unless
expressly set forth herein, no person acting on behalf of Sublandlord is
authorized to make, and by execution hereof of Subtenant acknowledges that no
person has made, any representation, agreement, statement, warranty, guaranty or
promise regarding the Demised Premises or the transaction contemplated herein;
and no such representation, warranty, agreement, guaranty, statement or promise
if any, made by any person acting on behalf of Sublandlord will be valid or
binding upon Sublandlord. Subtenant further acknowledges and agrees that having
been given the opportunity to inspect the Demised Premises, Subtenant is relying
solely on its own investigation of the Demised Premises and not on any
information provided or to be provided by Sublandlord except as expressly set
forth in this Agreement, and agrees to accept the Demised Premises at the
Commencement Date and waive all objections or claims against Sublandlord
(including, but not limited to, any right or claim of contribution) arising from
or related to the Demised Premises or to any Hazardous Materials on the
Demised Premises. Sublandlord shall not be liable or bound in any manner by any
oral or written statement, representation or information pertaining to the
Demised Premises furnished by any real estate broker, contractor, agent,
employee, servant or other.

                    16.6 Notwithstanding anything in this Section 16 to the
contrary, Prime Landlord will need to review and approve the plans for
Subtenant's Finish Work prior to the commencement of any construction, all in
accordance with the provisions of the Prime Lease. Any unreasonable delay
occasioned by Prime Landlord's review and approval process shall extend the
Commencement Date set forth in Section 2.1. Sublandlord shall solicit the
required consents from the Prime Landlord with the cooperation of Subtenant as
required.

                    16.7 Mailroom Monorail System. Subtenant acknowledges that
Sublandlord has previously installed a mailroom monorail between several floors
located in the core area of the Building. Sublandlord reserves the right at any
time to

                                      -18-
<PAGE>

enter the Demised Premises to access the mailroom monorail area for repair or
maintenance to the mailroom monorail system or the shaft and Subtenant shall not
restrict or obstruct in any way Sublandlord's access to the area marked by cross
hatching on the attached Exhibit _________.

                    16.8 Waiver of Mechanic's Lien. Prior to commencing any
construction, Subtenant shall obtain from the Subtenant Finish Contractor a
Waiver of Mechanic's Lien in recordable form.

                17. Tenant Improvement Allowance. Sublandlord shall make
available to Subtenant an improvement allowance of Nine Hundred Ninety Eight
Thousand Six Hundred Fifty Two Dollars ($998,652.00). Subtenant may use this
improvement allowance to offset construction costs for the Tenant Finish Work.
In the event that the total Tenant Improvement Allowance is not utilized at the
end of construction, then Subtenant shall have the right to either credit any
unutilized allowance against the Base Rent next due, or to apply any unused
allowance to supplement any other allowance category. Said Tenant Improvement
Allowance shall be paid to Subtenant or Subtenant's contractors within thirty
(30) days after Sublandlord is provided with evidence of paid invoices
representing the work in the case of payment made to Subtenant or partial of
final lien waivers in the case of payments made directly to contractors.

                18. Consent of Prime Landlord to this Sublease. Subtenant hereby
acknowledges and agrees that this Sublease is subject to and conditioned upon
Sublandlord obtaining the written consent (the "Consent") of Prime Landlord as
provided in the Lease. Promptly following the execution and delivery hereof,
Sublandlord shall submit this Sublease to Prime Landlord. Subtenant hereby
agrees that it shall cooperate in good faith with Sublandlord and shall comply
with any reasonable requests made of Subtenant by Sublandlord or Prime Landlord
in the procurement of the Consent. In no event shall Sublandlord or Subtenant be
obligated to make any payment to Prime Landlord in order to obtain the Consent
or the consent to any provision hereof, other than as expressly set forth in the
Lease. In the event that Prime Landlord shall not have executed and delivered
the Consent within thirty (30) days after the date of this Sublease, or in the
event that Prime Landlord objects to this Sublease then either party shall have
the right to cancel this Sublease by written notice given to the other at any
time thereafter prior to the execution and delivery of the Consent, and with the
giving of such notice this Sublease shall be deemed canceled and of no further
force or effect and neither party shall have any liability or obligation to the
other in respect thereof, except for any obligations or liabilities which have
accrued prior to such cancellation. In the event that this Sublease is canceled
by reason of Prime Landlord's objection or failure to consent, Subtenant hereby
agrees to vacate the Demised Premises upon 24 hours written notice to do so.

                19. Assignment, Subletting and Mortgaging.


                                      -19-
<PAGE>

                19.1 Subtenant shall not assign, sell, transfer (whether by
operation or law or otherwise), pledge, mortgage or otherwise encumber this
Sublease or any portion of its interest in the Demised Premises, nor sublet all
or any portion of the Demised Premises or permit any other person or entity to
use or occupy all or any portion of the Demised Premises, without the prior
written consent of Sublandlord and Prime Landlord. Upon the request of
Subtenant, Sublandlord, at Subtenant's sole cost and expense, shall request the
consent of the Prime Landlord and cooperate with Subtenant in obtaining any
consent.

                19.2 Notwithstanding the above, Subtenant shall have the right
to assign this sublease in its entirety or to sublease all or any portion of the
Demised Premises without the consent of Sublandlord to: (i) a successor to all
of Subtenant's businesses if such succession takes place by merger or
consolidation, reorganization, active legislation or other, or (ii) any
affiliate or subsidiary of Subtenant ("Permitted Transferee").

                19.3 If Subtenant desires at any time to assign this Sublease,
or sublet all or any portion of the Demised Premises, (except with respect to
transfers permitted pursuant to Section 19.2 above) Subtenant shall comply with
the following terms and conditions:

                     19.3.1 Subtenant shall first notify Sublandlord at least
sixty (60) days prior to the proposed effective date of the assignment or
sublease, in writing, of its desire to do so and shall submit in writing to
Landlord: (1) the name of the proposed subtenant or assignee, (2) the nature of
the proposed subtenant's or assignee's business to be carried on in the
Demised Premises, (3) the terms and conditions of the proposed sublease or
assignment, and (4) financial statements for the two most recent completed
fiscal years of the proposed Subtenant or assignee, and a bank reference.
Thereafter, Subtenant shall furnish such supplemental information as Sublandlord
may reasonably request concerning the proposed Subtenant or assignee. At any
time within fifteen (15) days after Sublandlord's receipt of the information
specified above, Sublandlord may by written notice to Subtenant elect to (1)
consent to the sublease or assignment, or (2) disapprove of the sublease or
assignment, said consent not to be unreasonably withheld or delayed. If
Sublandlord consents to the sublease or assignment within the fifteen (15) day
period, Subtenant may thereafter enter into such assignment or sublease of the
Demised Premises, or a portion thereof, upon the terms and conditions and as of
the effective date set forth in the information furnished by Subtenant to
Sublandlord, provided that nothing herein shall detract from Subtenant's
requirement to obtain Prime Landlord's consent to any sublease or assignment.

                     19.3.2 Notwithstanding Sublandlord having granted its
consent to any assignment or subleasing, prior to the effective date of any
assignment

                                      -20-
<PAGE>

or commencement date of any sublease, Sublandlord shall be furnished with a copy
of the fully executed sublease or assignment of the sublease agreement.

                     19.3.3 No sublease of the Demised Premises or portion
thereof, or assignment of this sublease, shall be for a period of less than one
(1) year nor shall any sublease extend beyond the expiration date of the term of
this sublease.

                     19.3.4 Notwithstanding any other provision of this
Sublease, Subtenant may not enter into any sublease, license, concession or
other agreement for use, occupancy or utilization of space in the Demised
Premises which provides for a rental or other payment for such use, occupancy or
utilization based in whole or in part on the net income or profits derived by
any person from the property leased, occupied or utilized, or which would
require the payment of any consideration which would not fall within the
definition of "rents from real property" as that term is defined in Section
856(d) of the Internal Revenue Code of 1986, as amended.

                19.4 Subtenant shall pay to Sublandlord as additional rent,
within five (5) business days following the due dates of such sums (after
subtracting therefrom the expenses of subletting including advertising,
brokerage commission, legal fees and alteration expenses) Fifty percent (50%) of
the amount by which (a) the rent payable by such assignee, sublessee or
sublessees to Subtenant, throughout the term exceeds the rent otherwise payable
by Subtenant to Sublandlord under this sublease; plus (b) fifty percent (50%) of
all other consideration payable for the assignment or sublease of this Sublease
for the area assigned or sublet, computed on the basis of an average rent per
rentable square foot of area assigned or sublet. The foregoing is a freely
negotiated arrangement between Sublandlord and Subtenant, respecting the
allocation of appreciated rentals. This covenant shall survive the expiration of
the term of this sublease.

                19.5 Any notice by Subtenant to Sublandlord pursuant to this
Section 19 of a proposed assignment or subletting, shall be accompanied by
payment of Five Hundred Dollars ($500.00) as a non-refundable fee for
Sublandlord's time and the processing of Subtenant's request for Sublandlord's
consent. In addition to said fee, Subtenant shall reimburse Sublandlord for
reasonable attorneys' fees incurred by Sublandlord in connection with such
review and the preparation of documents in connection therewith.

                19.6 Each permitted assignee, transferee or sublessee other than
Sublandlord shall assume and be deemed to have assumed this sublease and shall
remain liable jointly and severally with Subtenant for the payment of the rent
and for the due performance or satisfaction of all of the provisions, covenants,
conditions and agreements herein contained on Subtenant's part to be performed
or satisfied. No permitted assignment or sublease shall be binding on
Sublandlord unless such assignee, sublessee or Subtenant shall deliver to
Sublandlord a counterpart of such

                                      -21-
<PAGE>

assignment or sublease which contains a covenant of assumption by the assignee
or sublessee, but the failure or refusal of the assignee or sublessee to execute
such instrument of assumption shall not release or discharge the assignee or
sublessee from its liability set forth above.

                19.7 If this Sublease be assigned, or if the Demised Premises of
any part thereof be sublet (whether or not Sublandlord, and Prime Landlord shall
have consented thereto), Sublandlord, after default by Subtenant in its
obligations hereunder, may collect rent from the assignee or subtenant and apply
the amount collected to the Rental herein reserved, but no such assignment or
subletting shall be deemed the acceptance of the assignee or subtenant as a
tenant, or a release of Subtenant from the further performance and observance by
Subtenant of the covenants, obligations and agreements on the part of Subtenant
to be performed or observed herein. The consent by Sublandlord and Prime
Landlord to an assignment, sale, pledge, transfer, mortgage or subletting shall
not in any way be construed to relieve Subtenant from obtaining the express
consent in writing, to the extent required by this Sublease or the Prime Lease
or Prime Sublease, of Sublandlord and Prime Landlord and Landlord to any further
assignment, sale, pledge, transfer, mortgage or subletting.

                19.8 If Subtenant is a partnership, the admission of new
Partners (hereinafter defined), the retirement, death, withdrawal, incompetency
or bankruptcy of any Partner, or the reallocation of partnership interests among
the Partners shall not constitute an assignment of this Sublease requiring the
prior consent of Sublandlord. The reorganization of Subtenant into a
professional corporation if Subtenant is a partnership, or the reorganization of
Subtenant from a professional corporation into a partnership, shall not
constitute an assignment of this Sublease requiring the prior consent of
Sublandlord, provided that (i) immediately following such reorganization the
Partners of Subtenant shall be not less than ninety percent (90%) of those
Partners existing immediately prior to such reorganization and (ii) any Partner
of Subtenant immediately prior to-such reorganization who is not a Partner of
Subtenant immediately after such reorganization shall be released from liability
under this Sublease only to the extent permitted by and in accordance with the
provisions of Section 19.2 hereof. Any such reorganization either at one time or
over a twelve (12) month period shall be considered the same reorganization. If
Subtenant shall become a professional corporation, each individual shareholder
in Subtenant and each attorney-employee of a professional corporation which is a
shareholder in Subtenant shall have the same personal liability as such
individual or attorney-employee would have under this Sublease if Subtenant were
a partnership and such individual or attorney-employee were a Partner of
Subtenant. Upon the request of Sublandlord, each such individual or
attorney-employee shall execute an agreement confirming such personal liability.
A "Partner" shall be any partner of Subtenant or any attorney-employee of a
professional corporation which is a partner of Subtenant and any shareholder of
Subtenant if Subtenant shall become a professional corporation.

                                      -22-
<PAGE>

                19.9 Except as set forth above, either a transfer (including the
issuance of treasury stock or the creation and issuance of new stock) of a
controlling interest in the shares of Subtenant (if Subtenant is a corporation,
other than a professional corporation, or trust) or a transfer of a majority of
the total interest in Subtenant (if Subtenant is a partnership) at any one time
or over a period of time through a series of transfers, shall be deemed an
assignment of this Sublease and shall be subject to all of the provisions of
this Agreement, including, without limitation, the requirements that Subtenant
obtain Sublandlord's prior consent thereto. The transfer of shares of Subtenant
(if Subtenant is a corporation or trust) for purposes of this Section shall not
include the sale of shares by persons other than those deemed "insiders" within
the meaning of the Securities Exchange Act of 1934, as amended, which sale is
effected through the "over-the-counter market" or through any recognized stock
exchange.

            20. Insurance. Subtenant shall obtain and keep in full force and
effect during the term of the Sublease, at its own cost and expense,
comprehensive public liability and property damage insurance with a broad form
contractual liability endorsement with a minimum limit of liability of
$3,000,000 for injury or death and damages to any one person, of $3,000,000 for
injury or death arising out of one occurrence, and $3,000,000 for damage to
property, naming Sublandlord and Subtenant as insureds against any and all
claims for personal injury, death or property damage occurring in, upon,
adjacent to, or connected with the Subleased Demised Premises or any part
thereof. Said insurance is to be written in form reasonably satisfactory to
Sublandlord by good and solvent insurance companies of recognized standing,
admitted to do business in the State of Pennsylvania which shall be reasonably
satisfactory to Sublandlord. Subtenant shall pay all premiums and charges
therefor and upon failure to do so Sublandlord may, but shall not be obligated
to, make such payments, in which event Subtenant agrees to pay the amount
thereof to Sublandlord on demand. Such policies shall contain a provision that
no act or omission of Subtenant will affect or limit the obligation of the
insurance company to pay the amount of any loss sustained and shall be
noncancellable except upon thirty (30) days advance written notice to
Sublandlord. In the event Subtenant shall fail to obtain such insurance,
Sublandlord may, but shall not be obligated to, obtain the same, in which event
the amount of the premium paid shall be paid by Subtenant to Sublandlord upon
demand.

            21. Partnerships If Subtenant is a partnership (or is comprised of
two (2) or more persons, individually or as co-partners of a partnership or
joint venture) or if Subtenant's interest in this Sublease shall be assigned to
a partnership (or two (2) or more persons individually or as co-partners of a
partnership or joint venture) or to a professional corporation pursuant to
Section 19 hereof (any such partnership, professional corporation and such
persons are referred to in this Article as "Partnership Subtenant"), then (i)
the liability of each of the parties comprising Partnership Subtenant shall be
joint and several, (ii) each of the parties comprising Partnership Subtenant
hereby consents in advance to, and agrees to be bound by, any written instrument
which may hereafter be executed by Subtenant, changing, modifying or discharging
this

                                      -23-
<PAGE>

Sublease, in whole or in part, or surrendering all or any part of the Demised
Premises to Sublandlord, and by any notices, demands, requests or other
communications which may hereafter be given by Partnership Subtenant or by any
of the parties comprising Partnership Subtenant, (iii) any bills, statements,
notices, demands, requests or other communications given or rendered to or by a
Partner of Partnership Subtenant shall be binding upon Partnership Subtenant,
(iv) if any individual Partner of Partnership Subtenant is or becomes an
attorney-employee of a professional corporation, such individual shall have the
same personal liability under this Sublease as such individual would have if he
and not the professional corporation were a Partner of Partnership Subtenant,
and such individual, upon the request of Sublandlord, shall execute an agreement
confirming such personal liability, (v) if Partnership Subtenant shall admit new
Partners, all of such new Partners shall, by their admission to Partnership
Subtenant, be deemed to have assumed joint and several liability for the
performance of all of the terms, covenants and conditions of this Sublease on
Partnership Subtenant's part to be observed and performed, and (vi) Partnership
Subtenant shall give prompt notice to Sublandlord of the admission of any new
Partners and the death, retirement, withdrawal, incompetency or bankruptcy of
any Partner, and, upon demand of Sublandlord, shall cause each such new Partner
to execute and deliver to Sublandlord an agreement in form satisfactory to
Sublandlord, wherein each such new Partner shall assume joint and several
liability for the performance of all the terms, covenants and conditions of this
Sublease on Subtenant's part to be observed and performed (but neither
Sublandlord's failure to request any such agreement nor the failure of any such
new Partner to execute or deliver any such agreement to Sublandlord shall
vitiate the provisions of this Section 21).

            22. Default

                22.1 In additional to the remedies set forth in the Prime Lease,
in the event of a default by Subtenant under the terms or conditions of this
Sublease, Subtenant hereby agrees to the Confession of Judgment provisions set
forth below:

THE FOLLOWING PARAGRAPH SETS FORTH A WARRANT OR AUTHORITY FOR AN ATTORNEY (OR A
CLERK OF COURT OR A PROTHONOTARY) TO CONFESS JUDGMENT AGAINST TENANT. SINCE THIS
PARAGRAPH REQUIRES TENANT TO WAIVE IMPORTANT DUE-PROCESS RIGHTS AND OTHER
CONSTITUTIONAL RIGHTS, SUBTENANT AND SUBLANDLORD AGREE THAT IT IS APPROPRIATE
FOR SUBTENANT TO PROVIDE A SPECIAL ACKNOWLEDGMENT THAT SUBTENANT WAIVES THOSE
RIGHTS KNOWINGLY AND VOLUNTARILY. IN MAKING THIS SPECIAL ACKNOWLEDGMENT,
SUBTENANT EXPRESSLY, KNOWINGLY AND VOLUNTARILY MAKES THE FOLLOWING
REPRESENTATIONS, ACKNOWLEDGMENTS, AND ASSURANCES (IN WHICH "YOU" SHALL MEAN
SUBTENANT OR, IF APPROPRIATE SUBTENANT'S HEIRS, SUCCESSORS AND/OR ASSIGNS):

                                      -24-
<PAGE>

     (I) YOU HAVE DISCUSSED WITH YOUR OWN LEGAL COUNSEL THE CONSEQUENCES OF
GRANTING THE WARRANTS OR POWERS OF ATTORNEY IN THE SUBLEASE (OR YOU HAVE
WILLFULLY AND KNOWINGLY ELECTED NOT TO HAVE SUCH A DISCUSSION WITH AN ATTORNEY
WHO REPRESENTS YOU).

     (II) YOU UNDERSTAND THE CONSEQUENCES OF GRANTING SUCH WARRANTS OR POWERS OF
ATTORNEY, INCLUDING BUT NOT LIMITED TO THE FACT THAT YOU ARE THEREBY WAIVING
IMPORTANT RIGHTS THAT YOU WOULD OTHERWISE HAVE UNDER THE CONSTITUTIONS OF THE
UNITED STATES OF AMERICA AND OF THE COMMONWEALTH OF PENNSYLVANIA.

     (III) YOU UNDERSTAND THAT AMONG THE RIGHTS YOU WILL WAIVE BY GRANTING SUCH
WARRANTS OR POWERS OF ATTORNEY ARE: (A) THE RIGHT TO RECEIVE PRIOR NOTICE OF
PROCEEDINGS TO ENFORCE SUCH A JUDGMENT BY HAVING A SHERIFF OR MARSHAL EVICT YOU
FROM THE LEASEHOLD SPACE, AND (B) THE RIGHT TO HAVE A HEARING CONDUCTED BEFORE
YOU ARE DEPRIVED OR YOUR PROPERTY AS A RESULT OF SUCH ENFORCEMENT PROCEEDINGS.

     (IV) NO ONE HAS EXERCISED ANY FORCE OR MADE ANY THREATS OR TAKEN ANY ACTS
THAT HAVE DEPRIVED YOU OF YOUR FREE WILL IN DECIDING WHETHER TO GRANT SUCH A
WARRANT OF ATTORNEY.

     (V) YOU UNDERSTAND THAT SUBLANDLORD AND ITS ATTORNEYS AND AGENTS ARE
RELYING UPON YOUR ASSURANCE THAT THESE ACKNOWLEDGMENTS AND REPRESENTATIONS ARE
TRUE.



                                      -25-
<PAGE>

                             CONFESSION OF JUDGMENT
                             ----------------------

     1. Warrant and Power of Attorney to Confess Judgment in Ejectment. When
this Sublease and the Term thereof or Subtenant's right to possession of the
Demised Premises shall have been terminated on account of any Event of Default
by Subtenant hereunder, and also when the Term hereby created shall have
expired, it shall be lawful for any attorney to appear as attorney for
Subtenant, as well as for all persons claiming by, through or under Subtenant,
and to sign an agreement for entering in any competent court an amicable action
in ejectment against Subtenant and all persons claiming by, through or under
Subtenant and therein confess judgment for the recovery by Sublandlord of
possession of the Demised Premises. This Sublease shall be his sufficient
warrant, whereupon, if Sublandlord so desires, a writ of possession may issue
forthwith, without any prior writ or proceedings whatsoever. If for any reason
after such action shall have been commenced the same shall be determined and the
possession of the Demised Premises hereby demised remain in or be restored to
Subtenant, Sublandlord shall have the right for the same default and upon any
subsequent defaults, or upon the termination of this Sublease, to bring one or
more further amicable action or actions as hereinbefore set forth to recover the
possession of said Demised Premises and confess judgment for the recovery of
possession of the Demised Premises as hereinbefore provided.

     2. Release. Subtenant hereby unconditionally and forever releases and
waives (i) all rights that Subtenant would otherwise have to object to,
interfere with, attack, seek to strike or open, or seek to stay the aforesaid
entry of judgment or judgments and/or the aforesaid issuance and consummation of
execution or executions thereon, (ii) any and all errors heretofore or hereafter
committed by Sublandlord in connection with this Sublease and/or in connection
with Sublandlord's enforcement of its rights under this paragraph, (iii)
inquisition and condemnation of any property seized or levied upon by virtue of
such execution, and (iv) any exemptions to which Subtenant would otherwise be
entitled under any statute, law, ordinance, regulation or rule of law.

     4. Affidavit of Default. In any amicable action brought hereon, or other
action brought pursuant to the foregoing warrants and powers of attorney (to
confess judgment herein), Sublandlord shall cause to be filed in such action an
affidavit made by it or someone acting for it, setting forth the facts necessary
to authorize the entry of judgment, of which facts such affidavit shall be prima
facie evidence, and if a true copy of this Sublease (and of the truth of the
copy such affidavit shall be sufficient evidence) shall be filed in such suit,
action or actions, it shall not be necessary to file the original as a warrant
of attorney, any rule of court, custom or practice to the contrary
notwithstanding.


                                      -26-
<PAGE>

     23. Holding Over. In the event Subtenant holds over after the expiration of
the term of this Lease, then, in addition to any other rights or remedies
Sublandlord may have as provided in the Prime Lease, Subtenant shall indemnify,
protect, defend and hold harmless Sublandlord, from and against any and all
claims, suits, demands, liability, damages and expenses, including direct and
consequential damages sustained by Sublandlord, together with reasonable
attorneys' fees and costs, if any, arising from or in connection with
Subtenant's failure to vacate the Demised Premises at the termination or sooner
expiration of the term of this Sublease.

     24. Non-Disturbance Agreement. Upon Subtenant's request, Sublandlord will
use reasonable efforts to assist Subtenant in obtaining a Non-Disturbance
Agreement from the current lender on the property provided that: (i) the failure
of Subtenant to obtain such a Non-Disturbance Agreement shall not give Subtenant
the right to terminate this Sublease and provided further that Sublandlord shall
not be required to make any payments to the Prime Landlord or the current lender
to obtain such Non-Disturbance Agreement nor shall Sublandlord be required to
make any concessions with respect to the Prime Lease.

     25. Miscellaneous.

         25.1 This Sublease contains the entire agreement between the parties
and all prior negotiations and agreements are merged in this Sublease. Any
agreement hereafter made shall be ineffective to change, modify or discharge
this Sublease in whole or in part unless such agreement is in writing and signed
by the parties hereto. No provision of this Sublease shall be deemed to have
been waived by Sublandlord or Subtenant unless such waiver be in writing and
signed by Sublandlord or Subtenant, as the case may be. The covenants and
agreements contained in this Sublease shall bind and inure to the benefit of
Sublandlord and Subtenant and their respective permitted successors and assigns.

         25.2 In the event that any provision of this Sublease shall be held to
be invalid or unenforceable in any respect, the validity, legality or
enforceability of the remaining provisions of this Sublease shall be unaffected
thereby.

         25.3 The paragraph headings appearing herein are for purpose of
convenience only and are not deemed to be a part of this Sublease.

         25.4 Capitalized terms used herein shall have the same meanings as are
ascribed to them in the Prime Sublease, unless otherwise expressly defined
herein.

         25.5 This Sublease shall be governed by, and construed in accordance
with, the laws of the Commonwealth of Pennsylvania.


                                      -27-
<PAGE>

         25.6 This Sublease is offered to Subtenant for signature with the
express understanding and agreement that this Sublease shall not be binding upon
Sublandlord unless and until Sublandlord shall have executed and delivered a
fully executed copy of this Sublease to Subtenant.

        IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement
of Sublease as of the day and year first above written.

Witness:                                Raytheon Engineers & Constructors, Inc.

                                        By:
------------------------------              -----------------------------------
                                        Name:
                                            -----------------------------------
                                        Title:
                                            -----------------------------------

Witness:                                Premier Research Worldwide, Ltd.


                                        By: /s/ Fred M. Powell
------------------------------              -----------------------------------
                                        Name: Fred M. Powell
                                            -----------------------------------
                                        Title: Chief Financial Officer
                                            -----------------------------------


                          ACKNOWLEDGMENT OF SUBTENANT
                          ---------------------------

     Subtenant hereby acknowledges again its consent to the following provisions
of Section 22 of the Sublease as follows:

1. Warrant and Power of Attorney to Confess Judgment in Ejectment. When this
Sublease and the Term thereof or Subtenant's right to possession of the
Demised Premises shall have been terminated on account of any Event of Default
by Subtenant hereunder, and also when the Term hereby created shall have
expired, it shall be lawful for any attorney to appear as attorney for
Subtenant, as well as for all persons claiming by, through or under Subtenant,
and to sign an agreement for entering in any competent court an amicable action
in ejectment against Subtenant and all persons claiming by, through or under
Subtenant and therein confess judgment for the recovery by Sublandlord of
possession of the Demised Premises. This Sublease shall be his

                                      -28-
<PAGE>

sufficient warrant, whereupon, if Sublandlord so desires, a writ of possession
may issue forthwith, without any prior writ or proceedings whatsoever. If for
any reason after such action shall have been commenced the same shall be
determined and the possession of the Demised Premises hereby demised remain in
or be restored to Subtenant, Sublandlord shall have the right for the same
default and upon any subsequent defaults, or upon the termination of this
Sublease, to bring one or more further amicable action or actions as
hereinbefore set forth to recover the possession of said Demised Premises and
confess judgment for the recovery of possession of the Demised Premises as
hereinbefore provided.

     3. Release. Subtenant hereby unconditionally and forever releases and
waives (i) all rights that Subtenant would otherwise have to object to,
interfere with, attack, seek to strike or open, or seek to stay the aforesaid
entry of judgment or judgments and/or the aforesaid issuance and consummation of
execution or executions thereon, (ii) any and all errors heretofore or hereafter
committed by Landlord in connection with this Sublease and/or in connection with
Sublandlord's enforcement of its rights under this paragraph and (iii) any
exemptions to which Subtenant would otherwise be entitled under any statute,
law, ordinance, regulation or rule of law.

     4. Affidavit of Default. In any amicable action brought hereon, or other
action brought pursuant to the foregoing warrants and powers of attorney (to
confess judgment herein), Sublandlord shall cause to be filed in such action an
affidavit made by it or someone acting for it, setting forth the facts necessary
to authorize the entry of judgment, of which facts such affidavit shall be prima
facie evidence, and if a true copy of this Sublease (and of the truth of the
copy such affidavit shall be sufficient evidence) shall be filed in such suit,
action or actions, it shall not be necessary to file the original as a warrant
of attorney, any rule of court, custom or practice to the contrary
notwithstanding.

Witness:                                       Premier Research Worldwide, Ltd.


                                               By: /s/ Fred M. Powell
-----------------------------                     -----------------------------
                                               Name: Fred M. Powell
                                                  -----------------------------
                                               Title: Chief Financial Officer
                                                  -----------------------------



                                      -29-
<PAGE>

                              CONSENT TO SUBLEASE

                         Shuwa Investments Corporation
                      515 South Flower Street, Suite 1270
                       Los Angeles, California 90071-2205
               Telephone (213) 489-2757 / Telefax (213) 489-2762

June ____, 1998

Raytheon Engineers & Constructors, Inc.
30 South 17th Street
Philadelphia, Pennsylvania 19103

    Re:  Building:               30 South 17th Street   
         Sublet Premises:        Entire 8th and 9th Floors    
         Date of Prime Lease:    June 13, 1973 as amended
         Date of Sublease:       June ____, 1998
         Landlord:               Shuwa Trust of Philadelphia, a Pennsylvania
                                 Business Trust
         Prime Lessee:           Raytheon Engineers & Constructors, Inc.
         Sublessee:              Premier Research Worldwide, Ltd.
        
Gentlemen:

     Pursuant to the terms of your Lease Agreement ("Prime Lease") covering the
above captioned Sublet Premises, as said Prime Lease may have been amended to
the date hereof, you have requested our consent to a sublease (dated as
described in the above caption) to the above captioned Sublessee, a copy of
which sublease is annexed hereto and made a part hereof and is hereinafter
referred to as the "Sublease".

     We hereby grant our consent to the Sublease upon the following express
terms and conditions:

     1. The Sublease is subject and subordinate to the Prime Lease and to all of
its terms, covenants, conditions, provisions and agreements.

     2. Neither the Sublease nor this consent thereto shall:

        (a) release or discharge you from any liability, whether past, present
or future, under the Prime Lease;

        (b) operate as a consent or approval by us to or of any of the terms,
covenants, conditions, provisions or agreement of the Sublease and we shall not
be bound thereby;

        (c) be construed to modify, waive or affect any of the terms, covenants,
conditions, provisions or agreements of the Prime Lease, or to waive any breach
thereof,

<PAGE>

or any of our rights as Landlord thereunder, or to enlarge or increase our
obligations as Landlord thereunder; or

        (d) be construed as a consent by us to any further subletting either by
you or by the Sublessee or to any assignment by you of the Prime Lease or
assignment by the Sublessee of the Sublease, whether or not the Sublease
purports to permit the same and, without limiting the generality of the
foregoing, both you and the Sublessee agree that the Sublessee has no right
whatsoever to assign, mortgage or encumber the Sublease nor to sublet any
portion of the Sublet Premises or permit any portion of the Sublet Premises to
be used or occupied by any other party.

     3. In the event of your default under the provisions of the Prime Lease,
the rent due from the Sublessee under the Sublease shall be deemed assigned to
us and we shall have the right, under such default, at any time at any option,
to give notice of such assignment to the Sublessee. We shall credit you with any
rent received by us under such assignment but the acceptance of any payment on
account of rent from the Sublessee as the result of any such default shall in no
manner whatsoever be deemed an attornment by the Sublessee to us in the absence
of a specific written agreement signed by us to such an effect, or serve to
release you from any liability under the terms, covenants, conditions,
provisions or agreements under the Prime Lease.

     Notwithstanding the foregoing, any payment other than rent from the
Sublessee directly to us, regardless of the circumstances or reasons therefore,
shall in no manner whatsoever be deemed an attornment by the Sublessee to us in
the absence of a specific written agreement signed by us to such an effect.

     4. Prime Lessee and Sublessee agree and acknowledge that Landlord's consent
herein shall not create or be deemed to be the basis of creating any covenant,
representation or warranty, express or implied (including, without limitation,
any covenant of quiet enjoyment), on the part of Landlord with respect to the
terms of the Sublease, Sublessee's, use and enjoyment of the Sublet Premises, or
any other matter arising out of or in connection with the Sublease.

     5. The term of the Sublease shall expire and come to an end on its natural
expiration date or any premature termination date thereof or concurrently with
the natural expiration date or any premature termination of the Prime Lease for
any reason whatsoever (including, without limitation, any termination by mutual
consent or other right, now or hereafter agreed to by Landlord or Prime Lessee,
or by operation of law or at Landlord's option in the event of a material
default by Prime Lessee).

     6. This consent is not assignable, nor shall this consent be a consent to
any amendment, or modification of the Sublease, without Landlord's prior written
consent.

     7. You and the Sublessee covenant and agree that, under no circumstances
shall we be liable for any brokerage commission or other charge or expense in
connection with the Sublease and you and the Sublessee agree to indemnify us
against same and against any cost or expense (including, but not limited to,
attorneys' fees) incurred by us in resisting any claim for any such brokerage
commission.

     8. You and Sublessee understand and acknowledge that Landlord's consent
hereto is not a consent to any improvement or alteration work being performed in
the Sublet Premises, that Landlord's consent must be separately sought if and to
the extent provided in the Prime Lease and will not necessarily be given, and
that if such consent is

                                      -2-
<PAGE>

given the same will be subject to you and Sublessee signing Landlord's standard
form of Agreement with respect to work being performed by persons other than
Landlord.

     9. Landlord's consent herein shall not constitute any agreement,
representation, warranty or verification that the Sublease is in compliance with
the Prime Lease.

     10. Landlord hereby confirms that the letter from Landlord's building
manager attached hereto as Exhibit 1, accurately states the policy that tenants
of the Building have 24 hour access to their premises, provided that such access
may be subject to interruptions caused by the performance of repairs and
alterations or force majeure events.

     The execution of a copy of this consent by you (as Prime Lessee) and by the
Sublessee shall indicate your joint and several confirmation of the foregoing
conditions and of your agreement to be bound thereby and shall constitute
Sublessee's acknowledgment that it has received a copy of the Prime Lease (with
principal economic terms omitted) from you.

Very truly yours,




LANDLORD:

SHUWA TRUST OF PHILADELPHIA,
a Pennsylvania Business Trust

By:  /s/ Takaji Kobayashi
     -------------------------------
     Takaji Kobayashi
Its: Trustee



                                      -3-
<PAGE>

CONFIRMED AND AGREED:

PRIME LESSEE:

RAYTHEON ENGINEERS & CONTRACTORS, INC.
a Delaware Corporation

By:
   ---------------------------------

Name:
     -------------------------------
    [Print Name]

Its:
    --------------------------------

CONFIRMED AND AGREED:

SUBLESSEE:

PREMIER RESEARCH WORLDWIDE, LTD.
a Delaware Corporation

By: /s/ Fred M. Powell
   ---------------------------------

Name: Fred M. Powell
     -------------------------------
     [Print Name]

Its: Chief Financial Officer
    --------------------------------



                                      -4-