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California-Alameda-1301 Marina Village Parkway Lease [Amendment No. 1] - Marina Village Office Lease and Alameda Real Estate Investments and BioMedicines Inc.

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Commercial Lease. Start a state-specific lease for the rental of commercial property. Specify the term and rent due, as well as whether the landlord or tenant is responsible for property taxes, insurance, and maintenance and repairs.
Commercial Sublease. When a tenant vacates commercial property before the lease term has expired, it may be able to rent the premises to a third party. The tenant would be the sublessor and the third party would be the sublessee. Besides preparing a sublease, both parties will want to review the provisions for assignment or subletting in the original lease agreement between the landlord and the sublessor.
Sublease Agreement. Tenants of residential property should prepare a sublease agreement if they are seeking to sublease a room or the entire apartment or house to a third party. All parties should review the original lease agreement to see if there are any restrictions on subletting or assigning the premises.
Triple Net Lease. Triple net leases are a type of commercial leases where the tenant has to pay for property taxes, insurance, utilities, and maintenance, in addition to the monthly rent.
Office Space Lease. When renting an office space, tenants should understand the amount of the rent and duration of the lease. Other important terms include whether the space can be subleased, which parties are responsible for maintenance, and whether any furniture and furnishings will be provided.

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                                 AMENDMENT NO. I
                                       TO
                           MARINA VILLAGE OFFICE LEASE


THIS AMENDMENT NO. 1 TO MARINA VILLAGE OFFICE LEASE is made and entered into as
of June 1, 1999, by and between ALAMEDA REAL ESTATE INVESTMENTS, a California
limited partnership ("Landlord") and BIOMEDICINES, INC., a Delaware corporation,
("Tenant").

Landlord and Tenant have previously entered into that certain Marina Village
Office Lease dated December 1, 1998, (the "Lease") with respect to certain
premises located in 1301 Marina Village Parkway, Suite 200, Alameda, California.
Landlord and Tenant now desire to amend the lease as hereinafter provided and,
accordingly, Landlord and Tenant hereby agree as follows (unless otherwise
defined, all capitalized terms used in this Amendment shall have the same
meanings as set forth in the Lease):

1.       AMENDMENT OF BASIC LEASE INFORMATION. The following provisions of the
         Basic Lease information are hereby amended to read as follows:


                                                                                      
          TERM EXPIRATION:                  Apri1 30, 2004
          BASE RENT:                        May 1, 1999 - April 30, 2000                       $10,509/month
                                            May 1, 2000 - April 30, 2001                       $10,785/month
                                            May 1, 2001 - April 30, 2002                       $11,062/month
                                            May 1, 2002 - April 30, 2003                       $11,339/month
                                            May 1, 2003 - April 30, 2004                       $11,615/month

          SECURITY DEPOSIT:                 $37610.80



2.       RATIFICATION. Landlord and Tenant hereby ratify and confirm all of the
         terms of the Lease as modified by paragraph 1 above. Except as
         expressly set forth to the contrary in this Amendment, the Lease, as
         amended, remains unmodified and in full force and effect. To the extent
         of any conflict between the terms of this Amendment and terms of the
         Lease, the terms of this Amendment shall control.


                                       1.
<PAGE>


IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment No. 1 as of
the date first set forth above.


TENANT:                                           LANDLORD:


                                              
BIOMEDICINES, INC.,                               ALAMEDA REAL ESTATE INVESTMENTS,
a Delaware corporation                            a California limited partnership

                                                  By:      Vintage Alameda Investments, LP
                                                           a California limited partnership,
                                                           operating general partner

                                                  By:      Vintage Properties - Alameda Commercial,
                                                           a California corporation,
                                                           managing general partner

By:                                               By:
   --------------------------------                  -------------------------------
Title:            CEO                             Title:         President
      -----------------------------                     ----------------------------