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Sample Business Contracts

Consulting Services Agreement - CytoTherapeutics Inc. and John Schwartz

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                      CONSULTING SERVICES AGREEMENT BETWEEN

                             CYTOTHERAPEUTICS, INC.
                                       AND
                                  JOHN SCHWARTZ

THIS CONSULTING SERVICES AGREEMENT (hereinafter referred to as the "Agreement")
effective as of the 27th day of July, 1998 (the "Effective Date"), as amended
and restated as of this 19th day of December, 1998, by and between
CytoTherapeutics, Inc., a corporation organized under the laws of the state of
Delaware with a place of business at 701 George Washington Highway, Lincoln,
Rhode Island 02865 (hereinafter referred to as "Company"), and John Schwartz, an
individual, with a place of business at 110 Atherton Avenue, Atherton,
California 94207 (hereinafter referred to as "Consultant").

In consideration of the promises and mutual covenants contained herein and on
the terms and conditions hereinafter set forth, it is agreed as follows:

1.    PROVISION OF SERVICES - Consultant shall provide to Company, at the
      direction of the Company's Chief Executive Officer and in cooperation with
      the Officers, employees and Directors of the Company, up to twenty (20)
      hours per month of strategic business advice and counsel ("Services"). In
      addition, when requested in writing by the Company's Chief Executive
      Officer, Consultant shall use his business judgment and experience to
      materially participate in the negotiation and consummation of a strategic
      collaboration transaction with third parties designated by the Company's
      Chief Executive Officer ("Additional Services"). Such Additional Services
      are not subject to the twenty (20) hours per month limit established for
      the Services.

2.    COMPENSATION - (a) Company agrees and shall compensate Consultant in
      consideration of his performance of the Services and the Additional
      Services as follows:

      (1)   Within ten (10) business days of the execution of this Agreement,
            and as compensation for Services rendered during the period of
            September 27, 1997 through July 26, 1998, the sum of Fifty Thousand
            Dollars ($50,000) in cash, plus a fully vested option, exercisable
            for a period of 10 years from the Effective Date, to purchase 20,000
            shares

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            of Company's common stock with an exercise price equal to the
            closing bid price for the shares of the Company's common stock as
            quoted by the Nasdaq stock market for the Effective Date of this
            Agreement ($1.281 per share);

      (2)   For Services to be rendered during the Term of this Agreement,
            Consultant shall be paid the sum of Five Thousand Dollars ($5,000)
            in cash per month on each of the monthly anniversaries of the
            Effective Date, for a total cash compensation of One Hundred Twenty
            Thousand Dollars ($120,000) during the Term of this Agreement. In
            addition, Consultant shall receive upon execution of this Agreement
            an option to purchase 76,000 shares of the Company's common stock
            with an exercise price equal to the closing bid price for the shares
            of the Company's common stock as quoted by the Nasdaq stock market
            for the Effective Date of this Agreement (the "Initial Option"), and
            on July 27, 1999, the first anniversary of the Effective Date, an
            option to purchase 48,000 shares of the Company's common stock with
            an exercise price equal to the closing bid price for the shares of
            the Company's common stock as quoted by the Nasdaq stock market for
            the date of such grant (the "Supplemental Option"). The Initial
            Option shall vest at the rate of 3,167 shares per month for the
            first 23 months, with a final vesting of 3,159 shares in the 24th
            month. The Supplemental Option, when granted, will vest at the rate
            of 2,000 shares per month for 24 months. Both the Initial Option and
            the Supplemental Option shall be exercisable for a period of 10
            years from the date of the initial grant.

      (3)   For the Additional Services, upon the consummation of a strategic
            collaboration transaction with such third party designated by the
            Company's Chief Executive Officer in accordance with Section 1
            hereof (the "Collaboration Agreement"), Consultant shall be paid a
            fee equal to three percent (3%) of the Transaction Consideration, as
            defined below (the "Additional Fee"), in accordance with the
            following terms:

            (i)   Payment of the Additional Fee shall be made within thirty (30)
                  days of the end of each calendar year and each such Additional
                  Fee payment shall be calculated on the basis of the
                  Transaction Consideration actually received by the Company in
                  the immediately preceding calendar year.

            (ii)  The Additional Fee shall be paid fifty percent (50%) in cash
                  and fifty percent (50%) in the form of an option or warrant,
                  at the election of the Company (the "Option"), to purchase

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                  registered shares of the Company's common stock, each such
                  Option being based on the following terms:

            (A)   The number of shares included in each such Option shall be
                  calculated by dividing the sum equal to one and a half percent
                  (1.5%) of the Transaction Consideration actually received in
                  the immediately preceding calendar year by the average closing
                  bid price for the common stock of the Company as quoted by the
                  Nasdaq stock market for the ten (10) trading days beginning
                  thirty (30) days immediately preceding the first public
                  announcement by the Company to occur (the "Closing Bid Price")
                  concerning (x) the consummation of the Collaboration
                  Agreement, or (y) the execution of a Letter of Intent with
                  respect to the Collaboration Agreement, or (z) the
                  confirmation of the existence of any discussions concerning
                  the Collaboration Agreement;

            (B)   Each such Option shall be fully vested upon their issuance,
                  shall bear an exercise price of twenty cents ($ 0.20) per
                  share and shall be exercisable for a period of ten years from
                  the date of their respective issuance.

            (iii) The Additional Fee shall be due and payable to Consultant for
                  each calendar year, or portion thereof, of the original term
                  of the Collaboration Agreement, as envisaged and specified
                  under the terms thereof, provided the Company receives
                  Transaction Consideration within such calendar year or portion
                  thereof. No Additional Fee shall be due and payable to
                  Consultant for any renewal period or extension of the original
                  term of the Collaboration Agreement.

            (iv)  In the event of (a) the sale and transfer of all or
                  substantially all of the assets of the Company, or (b) any
                  transaction as a result of which any one individual or entity
                  owns thirty percent (30%) or more of the common stock of the
                  Company (hereinafter "Change of Control"), then any Additional
                  Fee which would be due to Consultant during the remaining
                  portion of the original term of the Collaboration Agreement,
                  as envisaged and specified under the terms of thereof, shall
                  be accelerated and become due and payable within thirty (30)
                  days of such Change of Control. Solely for the purposes of
                  this Section 2(a)(3)(iv), the accelerated Additional Fee shall
                  be calculated on all Transaction Consideration due during the
                  remaining portion of the original term of the Collaboration
                  Agreement, but shall exclude any contingent payments which
                  would only be due upon the occurrence of a milestone event.


<PAGE>

                  For purposes of this Agreement, "Transaction Consideration"
                  means the total proceeds and other consideration paid and to
                  be paid or contributed and to be contributed to the Company
                  pursuant to a Collaboration Agreement and any amendment,
                  modification, novation, accord and satisfaction thereof,
                  including: (i) cash; (ii) notes, loans, and letters of credit
                  at the face value thereof, (iii) securities, and other
                  tangible and intangible property at the fair market value
                  thereof; and (iv) payments to be made to Company in
                  installments, such as annual sponsored research payments and
                  milestone payments for the achievement of established
                  criteria, but excluding royalties.

      (b)   In addition to the compensation set forth in paragraph 2(a) above,
            the Company agrees to reimburse Consultant for reasonable
            out-of-pocket expenses actually incurred by Consultant in the
            performance of the Services and the Additional Services, including,
            but not limited to telephone and facsimile charges and calls, car
            rental, lodging, travel expenses, meals and associated expenses.

3.    TERM - This Agreement shall enter into force and effect as of the
      Effective Date and shall remain in force and effect for a period of
      twenty-four (24) months (the "Term"). In the event this Agreement shall
      not be renewed beyond such Term, any provisions which by their nature
      and/or provisions extend beyond the Term of this Agreement shall survive
      the expiration of this Agreement and be binding on the parties hereto with
      full force and effect.

4.    CONFIDENTIALITY OF INFORMATION AND DOCUMENTS - In the event that Company
      shall submit information and/or documents to Consultant in order to permit
      him to perform the Services required under this Agreement, Consultant
      shall keep such information and/or documents in the strictest confidence
      using the same degree of care that Consultant uses in safeguarding his own
      confidential information both during and after the completion of the
      services under this Agreement and for a period of ten (10) years after
      completion of the Services, unless it shall receive from Company the
      consent of Company in writing to disclose it. However, nothing herein
      shall be interpreted as preventing Consultant from disclosing and/or using
      said information or documents which (i) are already rightfully in the
      possession of Consultant without obligation of confidence, but were not
      obtained directly or indirectly from Company or its affiliates; or (ii)
      are independently developed by Consultant not as part of the Services
      rendered or called for under the terms of this Agreement; or (iii) are or
      become available to the general public without breach of this Agreement;
      or (iv) are rightfully received by Consultant from a third party who is
      not under obligation of confidence, but who

<PAGE>

      did not obtain them directly or indirectly from Company or its affiliates;
      or (v) are required to be disclosed pursuant to law or court order, or as
      may be authorized by Company.

5.    LIABILITY OF CONSULTANT - In furnishing Company with the Services provided
      herein, Consultant shall not be liable to Company or its creditors for
      errors of judgment or for any matters, except for willful malfeasance, bad
      faith or gross negligence in the performance of the Services or Additional
      Services or the reckless disregard of its obligations and duties under the
      terms of this Agreement. It is further agreed and understood that
      Consultant may rely upon information furnished to it by Company which
      Consultant reasonably believes to be accurate and reliable and that,
      except as provided herein, Consultant shall not be accountable for any
      loss suffered by Company by the reason of Company's action or non-action
      on the basis of any advice, recommendation or approval of Consultant,
      except as provided above.

6.    INDEPENDENT CONTRACTOR - Execution of this Agreement in no way creates,
      nor shall this Agreement be interpreted or construed as creating, an
      employment, agency, partnership or joint venture relationship between
      Company and Consultant and it is understood Consultant will be acting as
      an independent contractor

7.    MISCELLANEOUS

      a.    OTHER ACTIVITIES OF CONSULTANT. Company recognizes that Consultant
            now renders and may continue to render management and other advisory
            services to other companies which may or may not have policies and
            conduct activities similar to those of Company. Consultant shall be
            free to render such advice and other services and Company hereby
            consents thereto. Consultant shall not be required to devote its
            full time and attention to the performance of the Services or the
            Additional Services hereunder to Company, but shall only devote so
            much of its time and attention as Company and Consultant mutually
            deem reasonable and necessary for such Services and Additional
            Services.

      b.    CONTROL. Nothing contained herein shall be deemed to require Company
            to take any action contrary to its Certificate of Incorporation or
            By-Laws, or any applicable statute or regulation, or to deprive its
            Officers and Board of Directors of their responsibility for any
            control of the conduct or the affairs of Company.


<PAGE>

      c.    This Agreement, read together with the letters addressed by the
            Company to Consultant dated July 27, 1998 and August 11, 1998
            (copies of which are attached hereto), shall constitute the entire
            agreement between Company and Consultant relating to the Services to
            be performed, and no representations, promises, understandings, or
            agreements, oral or otherwise, not herein contained shall be of any
            force or effect. No modification or waiver of any provision of this
            Agreement shall be valid unless it is in writing and signed by both
            Company and Consultant. This Agreement shall be binding upon the
            heirs, executors, administrators, successors and assigns of the
            parties hereto.

      d.    This Agreement shall be governed by, and construed in accordance
            with, the laws of the State of Delaware.

      e.    In the event of any litigation between the parties to declare or
            enforce any provision of this Agreement, the prevailing party shall
            be entitle to recover from the losing party, in addition to any
            other recovery and costs, reasonable attorney's fees and costs
            incurred in such litigation, in both the trial and in the appellate
            courts.

IN WITNESS WHEREOF, the parties hereto, by their duly authorized
representatives, have signed this Agreement as of the date first above written.


JOHN SCHWARTZ                                   CYTOTHERAPEUTICS, INC.


By:                                             By:
   ----------------------------                     Richard M. Rose, M.D.  
      John Schwartz                                 President &            
                                                    Chief Executive Officer