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Transition Agreement [Amendment] - Incyte Genomics Inc. and Roy A. Whitfield

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                                  AMENDMENT TO

                              TRANSITION AGREEMENT

         THIS AMENDMENT TO TRANSITION AGREEMENT (the "Amendment") by and between
INCYTE GENOMICS, INC., a Delaware corporation (the "Company"), and ROY A.
WHITFIELD (the "Executive"), is effective as of April 1, 2002.

         Whereas the Company and Executive entered into an employment agreement
dated as of May 2, 2001 (the "Prior Agreement"), which was superseded by that
certain Transition Agreement effective as of November 26, 2001 (the

         Whereas the Company and the Executive desire to amend the Agreement to
eliminate the provisions of the Agreement (and Prior Agreement) that purported
to modify the post-termination exercise provisions of Executive's outstanding
incentive stock options;

         Whereas the Company and Executive desire to amend the Agreement to
reflect a reduction in the number of hours per week during which Executive will
be employed as Chairman of the Board of Directors of the Company and to clarify
the Company's obligation with respect to the continuation of welfare benefits
following termination of employment; and

         Whereas the Compensation Committee of the Board of Directors of the
Company has determined that it is in the best interests of the Company to amend
the Agreement to so provide:

         NOW, THEREFORE, the Agreement is hereby amended as follows:

         1.  The Company and Executive acknowledge that Executive never provided
the form of consent required in order to effect a modification of his incentive
stock options under the terms of the Company's 1991 Stock Plan to extend the
period during which they would be exercisable following death, Disability or
Change in Control and, accordingly, notwithstanding the provisions of either the
Agreement or the Prior Agreement, the post-termination exercise provisions in
the incentive stock option agreements in effect as of the date of grant of such
options shall remain in effect, and any purported modification of such
provisions pursuant to the Agreement or the Prior Agreement shall be null and
void ab initio. Notwithstanding the foregoing, the provisions of the Agreement
which modify the vesting of the incentive stock options do not require such
consent and shall remain in effect.

         2.  Executive agrees that as of April 1, 2002, his position as Chairman
of the Board of Directors is modified from a full-time employment position to a
30 hour per week part-time employment position ending on August 2, 2002. The
Company and Executive agree that, notwithstanding the provisions of Section 2(b)
of the Agreement, the foregoing reduction in Executive's schedule shall not
cause the occurrence of the Transition Completion Date for purposes of the
Agreement until the termination of Executive's part-time employment on August 2,


         3.  The Company will compensate Executive for his part-time employment
services at 75% of the Annual Base Rate, payable in accordance with the
Company's standard payroll practices, and shall continue Executive's Welfare
Benefits in accordance with the terms of those plans. Executive acknowledges
that he remains ineligible to participate in any Company executive bonus or
other bonus programs, profit sharing plan or management incentive plan.
Executive further acknowledges that as of April 1, 2002, he has accrued 380
hours of paid time off, which he agrees to take at the rate of 22 hours per week
commencing April 1, 2002, and that during the period of the part-time
employment, Executive will not accrue additional paid time off.

         4.  The Company and Executive agree that the Company may satisfy its
obligation to provide continued disability benefits to Executive during the Term
by reimbursing Executive for the cost of disability insurance coverage obtained
by Executive, at the levels in effect under the Company's plan at the Transition
Completion Date. In addition, the Company may fulfill its obligation to provide
continued health benefits to Executive and Executive's family, (i) during the
portion of the Term that COBRA is available, by reimbursing Executive for the
cost of continued coverage for Executive and Executive's family under COBRA
(including medical, prescription, dental, vision), which Executive agrees to
elect in accordance with the applicable procedures or (ii) at any time
commencing twelve (12) months after the Transition Completion Date, as elected
by Executive, by reimbursing Executive for the cost of health insurance coverage
obtained by Executive, at the levels in effect under the Company's plan at the
Transition Completion Date.

         5.  This Amendment may be executed in counterparts, each of which shall
be deemed an original, but all of which together shall constitute one and the
same instrument.

         6.  Capitalized terms not otherwise defined herein shall have the
respective meanings set forth in the Agreement. Except as expressly set forth
above, the terms and provisions of Agreement shall continue in full force and
effect from and after the date hereof.

         IN WITNESS WHEREOF, the Executive and the Company, through its duly
authorized Officer, have executed this Amendment to be effective as of the day
and year first above written.


                                     /s/ Roy A. Whitfield


                                     By /s/ Paul A. Friedman

                                     Its Chief Executive Officer